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Protein

Inosine-5'-monophosphate dehydrogenase

Gene

IMPDH1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

K+UniRule annotation

Activity regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi: XMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from IMP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Inosine-5'-monophosphate dehydrogenase, Inosine-5'-monophosphate dehydrogenase (IMPDH1)
This subpathway is part of the pathway XMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from IMP, the pathway XMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi385Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi387Potassium; via carbonyl oxygenUniRule annotation1
Binding sitei388IMPUniRule annotation1
Active sitei390Thioimidate intermediateUniRule annotation1
Metal bindingi390Potassium; via carbonyl oxygenUniRule annotation1
Active sitei488Proton acceptorUniRule annotation1
Binding sitei500IMPUniRule annotation1
Metal bindingi555Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi333 – 335NADUniRule annotation3
Nucleotide bindingi383 – 385NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGMP biosynthesisUniRule annotation, Purine biosynthesis
LigandMetal-bindingUniRule annotation, NADUniRule annotation, PotassiumUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00601;UER00295

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenaseUniRule annotation
Short name:
IMPDUniRule annotation
Short name:
IMPDHUniRule annotation
Gene namesi
Name:IMPDH1Imported
Synonyms:IMPDHUniRule annotation
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000006425

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 232CBSInterPro annotationAdd BLAST60
Domaini238 – 296CBSInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni423 – 425IMP bindingUniRule annotation3
Regioni446 – 447IMP bindingUniRule annotation2
Regioni470 – 474IMP bindingUniRule annotation5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISZP Eukaryota
COG0517 LUCA
GeneTreeiENSGT00530000062923
InParanoidiM3Y524
OMAiSSMGYCG
OrthoDBiEOG091G0EAV

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_01964 IMPDH, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000644 CBS_dom
IPR005990 IMP_DH
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00571 CBS, 2 hits
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000130 IMPDH, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 2 hits
TIGRFAMsiTIGR01302 IMP_dehydrog, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS00487 IMP_DH_GMP_RED, 1 hit

Sequencei

Sequence statusi: Complete.

M3Y524-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGPLAPLTG SGPLPPPPPL RGGGAAAVPE PGARQHPGHE TAAQRYSARL
60 70 80 90 100
LQAGYEPESM ADYLISGGTG YVPEDGLTAQ QLFANADGLT YNDFLILPGF
110 120 130 140 150
IDFIADEVDL TSALTRKITL KTPLISSPMD TVTEADMAIA MALMGGIGFI
160 170 180 190 200
HHNCTPEFQA NEVRKVKKFE QGFITDPVVL SPSHTVGDVL EAKIRHGFSG
210 220 230 240 250
IPITETGTMG SKLVGIVTSR DIDFLAEKDH TTLLSEVMTP RNELVVAPAG
260 270 280 290 300
VTLKEANEIL QRSKKGKLPI VNDRDELVAI IARTDLKKNR DYPLASKDSH
310 320 330 340 350
KQLLCGAAVG TREDDKYRLD LLTQAGADVI VLDSSQGNSV YQIAMVHYIK
360 370 380 390 400
QKYPHLQVIG GNVVTAAQAK NLIDAGVDGL RVGMGCGSIC ITQEVMACGR
410 420 430 440 450
PQGTAVYKVA EYARRFGVPV IADGGIQTVG HVVKALALGA STVMMGSLLA
460 470 480 490 500
ATTEAPGEYF FSDGVRLKKY RGMGSLDAME KSSSSQKRYF SEGDKVKIAQ
510 520 530 540 550
GVSGSIQDKG SIQKFVPYLI AGIQHGCQDI GARSLSVLRS MMYSGELKFE
560 570
KRTMSAQIEG GVHGLHSYEK RLY
Length:573
Mass (Da):61,382
Last modified:May 1, 2013 - v1
Checksum:iFD334151144B4820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01009206 Genomic DNA No translation available.
AEYP01009207 Genomic DNA No translation available.
RefSeqiXP_004741882.1, XM_004741825.2

Genome annotation databases

EnsembliENSMPUT00000006536; ENSMPUP00000006425; ENSMPUG00000006480
GeneIDi101674461

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01009206 Genomic DNA No translation available.
AEYP01009207 Genomic DNA No translation available.
RefSeqiXP_004741882.1, XM_004741825.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000006425

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMPUT00000006536; ENSMPUP00000006425; ENSMPUG00000006480
GeneIDi101674461

Organism-specific databases

CTDi3614

Phylogenomic databases

eggNOGiENOG410ISZP Eukaryota
COG0517 LUCA
GeneTreeiENSGT00530000062923
InParanoidiM3Y524
OMAiSSMGYCG
OrthoDBiEOG091G0EAV

Enzyme and pathway databases

UniPathwayi
UPA00601;UER00295

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_01964 IMPDH, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000644 CBS_dom
IPR005990 IMP_DH
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00571 CBS, 2 hits
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000130 IMPDH, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 2 hits
TIGRFAMsiTIGR01302 IMP_dehydrog, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS00487 IMP_DH_GMP_RED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM3Y524_MUSPF
AccessioniPrimary (citable) accession number: M3Y524
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: November 7, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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