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Entry version 43 (02 Jun 2021)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

Signal induced proliferation associated 1 like 2

Gene

SIPA1L2

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Signal induced proliferation associated 1 like 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIPA1L2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000005560

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini593 – 810Rap-GAPInterPro annotationAdd BLAST218
Domaini948 – 1024PDZInterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni41 – 70DisorderedSequence analysisAdd BLAST30
Regioni357 – 399DisorderedSequence analysisAdd BLAST43
Regioni1065 – 1143DisorderedSequence analysisAdd BLAST79
Regioni1163 – 1243DisorderedSequence analysisAdd BLAST81
Regioni1328 – 1358DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1655 – 1703Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 62Polar residuesSequence analysisAdd BLAST18
Compositional biasi357 – 381Polar residuesSequence analysisAdd BLAST25
Compositional biasi382 – 399Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1089 – 1103Polar residuesSequence analysisAdd BLAST15
Compositional biasi1111 – 1132Polar residuesSequence analysisAdd BLAST22
Compositional biasi1163 – 1182Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1193 – 1211Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1212 – 1239Polar residuesSequence analysisAdd BLAST28
Compositional biasi1332 – 1358Polar residuesSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002127_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3Y2K9

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSRSMIH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR031203, SIPA1L2
IPR021818, SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF7, PTHR15711:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit
PF11881, SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3Y2K9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DEYFARKFKA INGNMGPPTS
60 70 80 90 100
LNASNSAESG GPANGTPAVP KMGVRARVCE WPPKKDCSKE LACKALWESR
110 120 130 140 150
SQASYESVPS ITHNGQNDQS DGQREEQLDL DFVEAKYTIG DIFVHSPQRG
160 170 180 190 200
LHPIRQRSNS DVTISDIDAE DVLDQNAVNP NTGAALHREY GSTSSIDRQG
210 220 230 240 250
LSGENFFAML RGYRVDNYDH KAMAPFGFPE FFPCDPAISP SLHAAAQISR
260 270 280 290 300
GEFVRISGLD YMDSALLMGR DRDKPFKRRL KSESVETSLF RKLRTVKSEH
310 320 330 340 350
ETFKFTCDPE DGRLERGVRP WNCQRCFAHY DVQSILFNIN EAMATRANMG
360 370 380 390 400
KRKNITTGAS AASQTQMPAG QTGNCESPLG SKEDLNSKEN LDADEGDGKS
410 420 430 440 450
NELVLSCPYF RNETGGEGDR RIALSRASSS SSSSGEGCSF ESSLSSHCTN
460 470 480 490 500
AGVSVLEVPR ESQPVHREKV KRYIIEHIDL GAYYYRKFFY GKEHQNYFGI
510 520 530 540 550
DENLGPVAVS IRREKVEDAK EKEGSQFNYR VAFRTSELTT LRGAILEDAI
560 570 580 590 600
PSTARHGTAR GLPLKEVLEY VIPELSIQCL RQAPNSPKVS EQLLKLDEQG
610 620 630 640 650
LSFQHKIGIL YCKAGQSTEE EMYNNETAGL AFEEFLDLLG QRVRLKGFSK
660 670 680 690 700
YRAQLDNKTD STGTHSLYTT YKDYEVMFHV STMLPYMPNN RQQLLRKRHI
710 720 730 740 750
GNDIVTIVFQ EPGALPFTPR SIRSHFQHVF VIVKVHNPCT ENVCYSVGVS
760 770 780 790 800
RSKDVPPFGP PIPKGVTFPK SAVFRDFLLA KVINAENAAH KSEKFRAMAT
810 820 830 840 850
RTRQEYLKDL AENFVTTATV DTSVKFSFIT LGAKKKEKVK PRKDAHLFSV
860 870 880 890 900
GAIMWHIIAR DFGQSADIEC LLGISNEFIM LIEKDSKNVV FNCSCRDVIG
910 920 930 940 950
WTSGLMSIKV FYERGECILL SSVDNCAEDV REIIQRLGIV TRGCETVEMT
960 970 980 990 1000
LRRNGLGQLG FHVNFEGIVA DVEPFGFAWK AGLRQGSRLV EICKVAVATL
1010 1020 1030 1040 1050
THEQMIDLLR TSVTVKVVII QPHDDGSPRR GCSELCRIPM VEYKLDSEGT
1060 1070 1080 1090 1100
PCEYKTPFRR NTTWHRVPTP ALQPLARASP VPGTPDRLPC QQLLQQAQAA
1110 1120 1130 1140 1150
IPRSTSFDRK LPDGTRSSPS NQSSSSDPGP GSSGPWRPQA AYDGCHSPLL
1160 1170 1180 1190 1200
LEHQGAGPLE CEGAREREDS LDGSRHLETK WHGPPSKVLS SYKERALQKD
1210 1220 1230 1240 1250
GSCKDSPNKL SHIGDKSCSS HSSSNTLSSN TSSNSDDKHF GSGDLMDPEL
1260 1270 1280 1290 1300
LGLTYIKGAS TDSGIDTAPC MPAAVLGPVH LAGSRSVIHS RAEQWADSAD
1310 1320 1330 1340 1350
IPGPDDEPAK MFAVHSYAPA ISAGSAADGS MGDLSEISSH SSGSHHSGSP
1360 1370 1380 1390 1400
SAHCSKNSGS LDTSKVYIVS HSSAQQVPGS VSKPYHRQGS VSKYVIGWKK
1410 1420 1430 1440 1450
SEGSPPPEEP EVAECQGLYG EMDLLSTAAQ QTVVGEAASE TQHVLSKEDF
1460 1470 1480 1490 1500
LKLMLPDSPL AEEGRRKFSF YGNLSPRRSL HRTLSDESVC SNRRGSPFGS
1510 1520 1530 1540 1550
SRSSVLDQAL PNDILFSTTP PYHSTLPPRT HPAPSMGSLR NEFWFSDGSL
1560 1570 1580 1590 1600
SDKSKCADPG LMPLPDTATG LDWSHLVDAA RAFEGLDSDE ELGLLCHHSS
1610 1620 1630 1640 1650
YLDQRVASFC TLTDMQHGED LEGAQEPPLC VDPGSGKEFM DTTGERSPST
1660 1670 1680 1690 1700
LTGKVNQLEL ILRQLQTDLR KEKQDKAVLQ AEVQHLRQDN RRLQEESQTA
1710
TAQLRKFTEW FFNTIDKKS
Length:1,719
Mass (Da):189,769
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA72882A7C8B3BB3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01088351 Genomic DNA No translation available.
AEYP01088352 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004776085.1, XM_004776028.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000005656; ENSMPUP00000005560; ENSMPUG00000005604

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101682374

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01088351 Genomic DNA No translation available.
AEYP01088352 Genomic DNA No translation available.
RefSeqiXP_004776085.1, XM_004776028.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000005560

Genome annotation databases

EnsembliENSMPUT00000005656; ENSMPUP00000005560; ENSMPUG00000005604
GeneIDi101682374

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57568

Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00940000157388
HOGENOMiCLU_002127_0_2_1
InParanoidiM3Y2K9
OMAiGSRSMIH

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR031203, SIPA1L2
IPR021818, SIPA1L_C
PANTHERiPTHR15711:SF7, PTHR15711:SF7, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit
PF11881, SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3Y2K9_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3Y2K9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 2, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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