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Entry version 60 (02 Jun 2021)
Sequence version 1 (01 May 2013)
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Protein

Diacylglycerol kinase

Gene

DGKD

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Lipid metabolism

This protein is involved in Lipid metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in Lipid metabolism.

Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationARBA annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00230

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000005480

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 103PHInterPro annotationAdd BLAST94
Domaini120 – 170Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini192 – 243Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52
Domaini274 – 408DAGKcInterPro annotationAdd BLAST135
Domaini1102 – 1165SAMInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni510 – 555DisorderedSequence analysisAdd BLAST46
Regioni587 – 621DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi510 – 524Polar residuesSequence analysisAdd BLAST15
Compositional biasi604 – 620Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1170, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159041

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001799_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3Y2C9

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNINSSM

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 2 hits
cd09575, SAM_DGK-delta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
2.30.29.30, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR037606, DGK-delta_SAM
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001660, SAM
IPR013761, SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF00169, PH, 1 hit
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00233, PH, 1 hit
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111331, SSF111331, 1 hit
SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50146, DAGK, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3Y2C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVVTSPAET VIKEGMLTKQ NNSFQRSKRR YFKLRGRTLY YAKTAKSIIF
60 70 80 90 100
DEVDLTDASV AESSTKNVNN SFTVITPCRK LILCADNRKE MEEWIAALKT
110 120 130 140 150
VQNREHFEPT QYSMDHFSGM HNWYACSHAR PTYCNVCREA LSGVTSHGLS
160 170 180 190 200
CEVCKFKAHK RCAVRATNNC KWTTLASIGK DIIEDEDGIA MPHQWLEGNL
210 220 230 240 250
PVSAKCTVCD KTCGSVLRLQ DWRCLWCKAM VHTSCKESLQ TKCPLGLCKV
260 270 280 290 300
SVIPPTALNS IDSDGFWKAT CPPSCTSPLL VFVNSKSGDN QGVKFLRRFK
310 320 330 340 350
QLLNPAQVFD LMNGGPHLGL RLFQKFDTFR ILVCGGDGSV GWVLSEIDSL
360 370 380 390 400
NLHKQCQLGV LPLGTGNDLA RVLGWGSACD DDTQLPQILE KLERASTKML
410 420 430 440 450
DRWSVMAYET KLPRQASSSM GTEDFSEGSE VQQILFYEDS VAAHLSKILT
460 470 480 490 500
SDQHSVVISS AKVLCETVKD FVARVGKAYE KTTESSEESE VMAKKCSVLK
510 520 530 540 550
EKLDSLLKTL DDESQASSSL PTPPPTIAEE VEDGDGAGSG CGSTGDRSVG
560 570 580 590 600
SACPARPQIF RPREQLMLRA NSLKKAIRQI IEHTEKAVDE QNAQTQEQEG
610 620 630 640 650
FALGLSESEE KKDLKSDDRV CPTESCGVAK GRSLRKVSKS PCEKLISKGS
660 670 680 690 700
LSLGSSASLP PQSGNRDGLP ALNTKILFSN VRAGMSGSLP GSSVISRLLI
710 720 730 740 750
NADPFNSEPE NLEYYTEKCV MNNYFGIGLD AKISLDFNNK RDEHPEKCRS
760 770 780 790 800
RTKNMMWYGV LGTKELLHRT YKNLEQKVLL ECDGRPIPLP SLQGIAVLNI
810 820 830 840 850
PSYAGGTNFW GGTKEDDTFA APSFDDKILE VVAVFGSMQM AVSRVIKLQH
860 870 880 890 900
HRIAQCRTVK ISILGDEGVP VQVDGEAWIQ PPGYIRIIHK NRAQTLTRDR
910 920 930 940 950
AFENTLKSWE DKQKCELPRP PSFSLHPEIL SEEEATQMDQ FGQAAGALIH
960 970 980 990 1000
SIREIAQSHQ DMERELAHAV NASSKSMDRV YGKPRTTEGL NCGFVLEMVN
1010 1020 1030 1040 1050
NIQALCRETA LLLAGRVALQ LDPPQKERLG AALTEMDQQL RKLADTPWLC
1060 1070 1080 1090 1100
QSVEPGDEEN VMLELSKRSR SGKFRLVTKF KKEKNSKNRE ARSSLGAPVH
1110 1120 1130 1140 1150
LWGTEEVAAW LEHLSLCEYK DIFTRHDIRG SELLHLERRD LKDLGVTKVG
1160 1170
HMKRILCGIK ELSRSTPATE A
Length:1,171
Mass (Da):130,057
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF05744A3BA18532
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01081424 Genomic DNA No translation available.
AEYP01081425 Genomic DNA No translation available.
AEYP01081426 Genomic DNA No translation available.
AEYP01081427 Genomic DNA No translation available.
AEYP01081428 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004773567.1, XM_004773510.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000005572; ENSMPUP00000005480; ENSMPUG00000005522

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101691397

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01081424 Genomic DNA No translation available.
AEYP01081425 Genomic DNA No translation available.
AEYP01081426 Genomic DNA No translation available.
AEYP01081427 Genomic DNA No translation available.
AEYP01081428 Genomic DNA No translation available.
RefSeqiXP_004773567.1, XM_004773510.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000005480

Genome annotation databases

EnsembliENSMPUT00000005572; ENSMPUP00000005480; ENSMPUG00000005522
GeneIDi101691397

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8527

Phylogenomic databases

eggNOGiKOG1170, Eukaryota
GeneTreeiENSGT00940000159041
HOGENOMiCLU_001799_3_0_1
InParanoidiM3Y2C9
OMAiRNINSSM

Enzyme and pathway databases

UniPathwayiUPA00230

Family and domain databases

CDDicd00029, C1, 2 hits
cd09575, SAM_DGK-delta, 1 hit
Gene3Di1.10.150.50, 1 hit
2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR037606, DGK-delta_SAM
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001660, SAM
IPR013761, SAM/pointed_sf
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF00169, PH, 1 hit
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00233, PH, 1 hit
SM00454, SAM, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
SSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3Y2C9_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3Y2C9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 2, 2021
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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