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Protein

Matrix metalloproteinase

Gene

MMP15

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei260UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP15Imported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei630 – 652HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_500404413946 – 674Matrix metalloproteinaseSequence analysisAdd BLAST629

Keywords - PTMi

Disulfide bondSAAS annotation, ZymogenUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000004656

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 305ZnMcInterPro annotationAdd BLAST171
Repeati367 – 415HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati416 – 461HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati463 – 511HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati512 – 559HemopexinPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
InParanoidiM3Y005
OMAiQHGDPGY
OrthoDBiEOG091G03DP

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028729 MMP15
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF25 PTHR10201:SF25, 1 hit
PfamiView protein in Pfam
PF11857 DUF3377, 1 hit
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

M3Y005-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSDRSAPGR PGWAVSILGG REAAARPRLL PLLLVLLGFL GRGAAAEDAE
60 70 80 90 100
VNAENWLRLY GYLPQPSRHM STMRSAQMLA SALAEMQRFY GIPVTGVLDE
110 120 130 140 150
ETKAWMKRPR CGVPDQFGVR VKANLRRRRK RYALTGRKWN NHHLTFSIQN
160 170 180 190 200
YTEKLGWYHS LEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL
210 220 230 240 250
FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG
260 270 280 290 300
NSLFLVAVHE LGHALGLEHS SNPSAIMAPF YQWMDTDSFQ LPEDDLRGIQ
310 320 330 340 350
QLYGTPDGQP QPTRPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP
360 370 380 390 400
GPPAQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV
410 420 430 440 450
LDNYPMPIGH FWRGLPSDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY
460 470 480 490 500
PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY
510 520 530 540 550
PKPISVWQGI PTSPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK
560 570 580 590 600
SILRDFMGCQ EHVEPGPRWP DVARPPFNPD GGAEPGAGEE GEEEEGGEAG
610 620 630 640 650
GAGDFGDGSD ADGGSRVVVQ MEEVTRTVNM VLVLVPPMLL LLCVLGLTYA
660 670
LVQMQRKGAP RVLLYCKRSL QEWV
Length:674
Mass (Da):76,207
Last modified:May 1, 2013 - v1
Checksum:i6EB92618F1940FF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01015539 Genomic DNA No translation available.
AEYP01015540 Genomic DNA No translation available.
RefSeqiXP_004744331.1, XM_004744274.2

Genome annotation databases

EnsembliENSMPUT00000004737; ENSMPUP00000004656; ENSMPUG00000004693
GeneIDi101670574

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01015539 Genomic DNA No translation available.
AEYP01015540 Genomic DNA No translation available.
RefSeqiXP_004744331.1, XM_004744274.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000004656

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMPUT00000004737; ENSMPUP00000004656; ENSMPUG00000004693
GeneIDi101670574

Organism-specific databases

CTDi4324

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
InParanoidiM3Y005
OMAiQHGDPGY
OrthoDBiEOG091G03DP

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028729 MMP15
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF25 PTHR10201:SF25, 1 hit
PfamiView protein in Pfam
PF11857 DUF3377, 1 hit
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiM3Y005_MUSPF
AccessioniPrimary (citable) accession number: M3Y005
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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