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Protein

DNA primase large subunit

Gene

PRIM2

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi289Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi369Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi386Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi426Iron-sulfur (4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRIM2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9669.ENSMPUP00000002605

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2267 Eukaryota
    COG2219 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000009790

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    M3XU55

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DCHGCPY

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd07322 PriL_PriS_Eukaryotic, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10537 PTHR10537, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF009449 DNA_primase_large_subunit, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    M3XU55-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MQFSRANWKR LRLTGDQRNV CYPHSLQFYL EPPSESISLI EFESLAIDRV
    60 70 80 90 100
    KLLKAVENLG VSYVKGTEPY QSKLESEIRR LKFSFRESLE NEYEPRRKDH
    110 120 130 140 150
    ISHFILRLAY CQSEDLRRWF IQQEMDLLRF RFSILPKDKI QNFLKDSHLH
    160 170 180 190 200
    FEAISDDEKK LREPEILASS PSLSGSKVDW ESESVYKIPF ADALDLFRGR
    210 220 230 240 250
    KVYLESGFAY VPLKDIVAIV LNEFRAKLSK ALALTARSLP AVQSDERLQP
    260 270 280 290 300
    LLNHLSHSYT GQDYSTQKNA GKISLDQIDS LSTRSFPPCM RQLHKALREN
    310 320 330 340 350
    HHLRHGGRMQ YGLFLKGIGL TLEQALQFWK QEFIRGKMDP DKFDKGYSYN
    360 370 380 390 400
    IRHSFGKEGK RTDYTPFSCM KIILTNPPSQ GDYHGCPFRH SDQELLKQKL
    410 420 430 440 450
    QSYKISPGGI HQILDLVKGT HYQVACQKYF EMIHNVDDCG FSLSHPNQFF
    460 470 480 490 500
    FESQRILSGN KDIRKESIQP ETPQPKPGVQ KAKDASSALA CLNSSLEMDM

    EGLEDYFSE
    Length:509
    Mass (Da):58,940
    Last modified:May 1, 2013 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i272F52C92637ED93
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AEYP01079104 Genomic DNA No translation available.
    AEYP01079105 Genomic DNA No translation available.
    AEYP01079106 Genomic DNA No translation available.
    AEYP01079107 Genomic DNA No translation available.
    AEYP01079108 Genomic DNA No translation available.
    AEYP01079109 Genomic DNA No translation available.
    AEYP01079110 Genomic DNA No translation available.
    AEYP01079111 Genomic DNA No translation available.
    AEYP01079112 Genomic DNA No translation available.
    AEYP01079113 Genomic DNA No translation available.

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_004772441.1, XM_004772384.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMPUT00000002659; ENSMPUP00000002605; ENSMPUG00000002633

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    101692327

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AEYP01079104 Genomic DNA No translation available.
    AEYP01079105 Genomic DNA No translation available.
    AEYP01079106 Genomic DNA No translation available.
    AEYP01079107 Genomic DNA No translation available.
    AEYP01079108 Genomic DNA No translation available.
    AEYP01079109 Genomic DNA No translation available.
    AEYP01079110 Genomic DNA No translation available.
    AEYP01079111 Genomic DNA No translation available.
    AEYP01079112 Genomic DNA No translation available.
    AEYP01079113 Genomic DNA No translation available.
    RefSeqiXP_004772441.1, XM_004772384.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Protein-protein interaction databases

    STRINGi9669.ENSMPUP00000002605

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMPUT00000002659; ENSMPUP00000002605; ENSMPUG00000002633
    GeneIDi101692327

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5558

    Phylogenomic databases

    eggNOGiKOG2267 Eukaryota
    COG2219 LUCA
    GeneTreeiENSGT00390000009790
    InParanoidiM3XU55
    OMAiDCHGCPY

    Family and domain databases

    CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
    InterProiView protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc
    PANTHERiPTHR10537 PTHR10537, 1 hit
    PfamiView protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit
    PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3XU55_MUSPF
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3XU55
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
    Last sequence update: May 1, 2013
    Last modified: January 16, 2019
    This is version 25 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported
    UniProt is an ELIXIR core data resource
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