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Protein

DNA primase large subunit

Gene

PRIM2

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi289Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi369Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi386Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi426Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM2Imported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi9669.ENSMPUP00000002605

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiKOG2267 Eukaryota
    COG2219 LUCA
    GeneTreeiENSGT00390000009790
    InParanoidiM3XU55
    OMAiDCHGCPY
    OrthoDBiEOG091G08G7

    Family and domain databases

    CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
    InterProiView protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc
    PANTHERiPTHR10537 PTHR10537, 1 hit
    PfamiView protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit
    PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

    Sequencei

    Sequence statusi: Complete.

    M3XU55-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MQFSRANWKR LRLTGDQRNV CYPHSLQFYL EPPSESISLI EFESLAIDRV
    60 70 80 90 100
    KLLKAVENLG VSYVKGTEPY QSKLESEIRR LKFSFRESLE NEYEPRRKDH
    110 120 130 140 150
    ISHFILRLAY CQSEDLRRWF IQQEMDLLRF RFSILPKDKI QNFLKDSHLH
    160 170 180 190 200
    FEAISDDEKK LREPEILASS PSLSGSKVDW ESESVYKIPF ADALDLFRGR
    210 220 230 240 250
    KVYLESGFAY VPLKDIVAIV LNEFRAKLSK ALALTARSLP AVQSDERLQP
    260 270 280 290 300
    LLNHLSHSYT GQDYSTQKNA GKISLDQIDS LSTRSFPPCM RQLHKALREN
    310 320 330 340 350
    HHLRHGGRMQ YGLFLKGIGL TLEQALQFWK QEFIRGKMDP DKFDKGYSYN
    360 370 380 390 400
    IRHSFGKEGK RTDYTPFSCM KIILTNPPSQ GDYHGCPFRH SDQELLKQKL
    410 420 430 440 450
    QSYKISPGGI HQILDLVKGT HYQVACQKYF EMIHNVDDCG FSLSHPNQFF
    460 470 480 490 500
    FESQRILSGN KDIRKESIQP ETPQPKPGVQ KAKDASSALA CLNSSLEMDM

    EGLEDYFSE
    Length:509
    Mass (Da):58,940
    Last modified:May 1, 2013 - v1
    Checksum:i272F52C92637ED93
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AEYP01079104 Genomic DNA No translation available.
    AEYP01079105 Genomic DNA No translation available.
    AEYP01079106 Genomic DNA No translation available.
    AEYP01079107 Genomic DNA No translation available.
    AEYP01079108 Genomic DNA No translation available.
    AEYP01079109 Genomic DNA No translation available.
    AEYP01079110 Genomic DNA No translation available.
    AEYP01079111 Genomic DNA No translation available.
    AEYP01079112 Genomic DNA No translation available.
    AEYP01079113 Genomic DNA No translation available.
    RefSeqiXP_004772441.1, XM_004772384.2

    Genome annotation databases

    EnsembliENSMPUT00000002659; ENSMPUP00000002605; ENSMPUG00000002633
    GeneIDi101692327

    Similar proteinsi

    Entry informationi

    Entry nameiM3XU55_MUSPF
    AccessioniPrimary (citable) accession number: M3XU55
    Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
    Last sequence update: May 1, 2013
    Last modified: March 28, 2018
    This is version 24 of the entry and version 1 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

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