Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 41 (02 Jun 2021)
Sequence version 1 (01 May 2013)
Previous versions | rss
Add a publicationFeedback
Protein

AF-4_C domain-containing protein

Gene

AFF1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF-4_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000002246

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini974 – 1225AF-4_CInterPro annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni76 – 185DisorderedSequence analysisAdd BLAST110
Regioni211 – 244DisorderedSequence analysisAdd BLAST34
Regioni271 – 322DisorderedSequence analysisAdd BLAST52
Regioni375 – 984DisorderedSequence analysisAdd BLAST610
Regioni1123 – 1147DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili989 – 1009Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 52Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi104 – 126Polar residuesSequence analysisAdd BLAST23
Compositional biasi151 – 168Polar residuesSequence analysisAdd BLAST18
Compositional biasi169 – 185Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi214 – 242Polar residuesSequence analysisAdd BLAST29
Compositional biasi379 – 433Polar residuesSequence analysisAdd BLAST55
Compositional biasi466 – 493Polar residuesSequence analysisAdd BLAST28
Compositional biasi517 – 537Polar residuesSequence analysisAdd BLAST21
Compositional biasi582 – 619Polar residuesSequence analysisAdd BLAST38
Compositional biasi652 – 690Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi724 – 738Polar residuesSequence analysisAdd BLAST15
Compositional biasi746 – 762Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi800 – 852Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi884 – 904Polar residuesSequence analysisAdd BLAST21
Compositional biasi933 – 949Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3XT46

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAMFRY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3XT46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAAQSSLYN EDRNLLRIRE KERRNQEAHQ EKEAFPEKIP LFGEPYKTEK
60 70 80 90 100
GDELSSRIQN MLGNYEEVKE FLSTKSHPHH LDASESGLGK PRYPLFPEKG
110 120 130 140 150
SSIPPHSFHT SAHHQPVNTP ASGPLPVGNI SHNPKMAQPR MEPMSNPHVK
160 170 180 190 200
SYGPPDSQHP TQDRLSQEGC GSSHHKKGER RADGDRCALV TGLAPERELA
210 220 230 240 250
PLLCLPSPVP PLSPVHSNQQ TLPRTQGSSK VHSSNSNSKG YCPAKSPKEL
260 270 280 290 300
VVKAHDKETA QDSLVAVASL GVAPPQPPSQ TFPPPSLPSK TVAMQQKPTA
310 320 330 340 350
YVRPMDGQDQ APSESPELKP LPEDYRQQTF EKTDLKVPAK AKLTKLKMPS
360 370 380 390 400
QSAEQTYSNE VHCVEEILKE MTHSWPPPLT AIHTPSTAEP SKFPFPTKDS
410 420 430 440 450
QHISSATQNQ KQYDTSSKIH TNSQQGTSML EDDLQLSDSE DSDNEQSPEK
460 470 480 490 500
PPPASAPPSA PQSLPAAAAS AHSSSAESES TSDSDSSSDS ESESSSSDSE
510 520 530 540 550
ENEPLETPAP EPEPPTTNKW QLDNWLTKVS QPTAPPDAQG NAEPPSRHTD
560 570 580 590 600
SKGKGGGDSS GPTASHGQER TESKDPPLKS SSKAPRGSSE GPHTGKRSCQ
610 620 630 640 650
KSPAPQEPLQ RQTVGTKQPK KPVKASAQAD PRAGLQVESE PGPPPPYGSK
660 670 680 690 700
DQPSKDKPKV KTKGRPRAGD SREPKPTAPS PSERKKHRSG PLAPSKALSG
710 720 730 740 750
PEPTKDNVGA RSPEHFALVP LTQSQGPPHG SGGGGSSGRT SGCRRAVVVQ
760 770 780 790 800
EDRRKDKLPG PGRDPKLLSP LRDTPPPPVL MVKITLDLLS RIPQLPGKGG
810 820 830 840 850
RPRRPEDKQS PAGKKLELEK RGADNSSKLA KKRKAEAEKD HDSKKARPEK
860 870 880 890 900
ETKSQSSSSS SHKESSKTKT SRPSSEPSKK EALPPPSASS SSSSSSSSSQ
910 920 930 940 950
KPAKPAQKRP KREADPCSQD PPQSASSSKG SHKDSSAPKH RKVEGKGSGS
960 970 980 990 1000
CPEHKGSSGD TAYPFLVPSL PNGNSKPGKP PVKLDRQQAD FHMKEAKKLK
1010 1020 1030 1040 1050
QKAELMTDKV GKAFKYLEAA LSLIECGIAM ESESPACKAA YSVYSESVDL
1060 1070 1080 1090 1100
IKFIMSLKSF SDASAPQEKI FAVLCMRCQS ILNMAMFRCK KDIAIKYSRA
1110 1120 1130 1140 1150
LNEHFSGLFK VAQAPSPCIA RTTGTPSPLS PMPSPVGSQP SAGSVGSSGM
1160 1170 1180 1190 1200
PVTIQNMTSS YVTITSHVLT AFDLWEQAEI LTRKNKEFFA QLSTSVCALA
1210 1220
LNSSLMDLVH YTRQGFQRLK QATKTP
Length:1,226
Mass (Da):132,060
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0D5661222931533
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01040868 Genomic DNA No translation available.
AEYP01040869 Genomic DNA No translation available.
AEYP01040870 Genomic DNA No translation available.
AEYP01040871 Genomic DNA No translation available.
AEYP01040872 Genomic DNA No translation available.
AEYP01040873 Genomic DNA No translation available.
AEYP01040874 Genomic DNA No translation available.
AEYP01040875 Genomic DNA No translation available.
AEYP01040876 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004756187.2, XM_004756130.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000002292; ENSMPUP00000002246; ENSMPUG00000002270

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101679180

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01040868 Genomic DNA No translation available.
AEYP01040869 Genomic DNA No translation available.
AEYP01040870 Genomic DNA No translation available.
AEYP01040871 Genomic DNA No translation available.
AEYP01040872 Genomic DNA No translation available.
AEYP01040873 Genomic DNA No translation available.
AEYP01040874 Genomic DNA No translation available.
AEYP01040875 Genomic DNA No translation available.
AEYP01040876 Genomic DNA No translation available.
RefSeqiXP_004756187.2, XM_004756130.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000002246

Genome annotation databases

EnsembliENSMPUT00000002292; ENSMPUP00000002246; ENSMPUG00000002270
GeneIDi101679180

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4299

Phylogenomic databases

eggNOGiENOG502QVDA, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiM3XT46
OMAiYMAMFRY

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3XT46_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3XT46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 2, 2021
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again