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Entry version 59 (02 Jun 2021)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

SH3 and multiple ankyrin repeat domains 3

Gene

SHANK3

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHANK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, SynapseARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

MethylationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000001849

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 338ANK_REP_REGIONInterPro annotationAdd BLAST205
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati151 – 184ANKPROSITE-ProRule annotationAdd BLAST34
Repeati185 – 217ANKPROSITE-ProRule annotationAdd BLAST33
Repeati252 – 284ANKPROSITE-ProRule annotationAdd BLAST33
Repeati285 – 317ANKPROSITE-ProRule annotationAdd BLAST33
Domaini475 – 534SH3InterPro annotationAdd BLAST60
Domaini575 – 669PDZInterPro annotationAdd BLAST95
Domaini1649 – 1712SAMInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni357 – 474DisorderedSequence analysisAdd BLAST118
Regioni669 – 693DisorderedSequence analysisAdd BLAST25
Regioni763 – 1529DisorderedSequence analysisAdd BLAST767
Regioni1550 – 1612DisorderedSequence analysisAdd BLAST63
Regioni1624 – 1657DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi406 – 422Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi783 – 797Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi814 – 851Pro residuesSequence analysisAdd BLAST38
Compositional biasi1179 – 1197Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1327 – 1352Pro residuesSequence analysisAdd BLAST26
Compositional biasi1371 – 1404Polar residuesSequence analysisAdd BLAST34

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota
KOG4375, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001824_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3XRZ9

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEDENGW

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.25.40.20, 2 hits
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF17820, PDZ_6, 1 hit
PF00536, SAM_1, 1 hit
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits
SM00228, PDZ, 1 hit
SM00454, SAM, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS50106, PDZ, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3XRZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LEGPGFTALG VVVRVNHDPA PPQKCLRLDP AAPVWAAKQR VLCALNHSLQ
60 70 80 90 100
DALNYGLFQP PSRGRAGKFL DEERLLQEYP PNLDTPLPYL EQFRYKRRVY
110 120 130 140 150
AQNLIDDKQF AKLHTKANLK KFMDYVQLHS TDRVARLLDK GLDPNFHDPD
160 170 180 190 200
SGECPLSLAA QLDNATDLLK VLRNGGAHLD FRTRDGLTAV HCATRQRNAA
210 220 230 240 250
ALTTLLDLGA SPDYKDSRGL TPLYHSALGG GDALCCELLL HDHAQLGTTD
260 270 280 290 300
ENGWQEIHQA CRFGHVQHLE HLLFYGADMG AQNASGNTAL HICALYNQES
310 320 330 340 350
CARVLLFRGA NKDVRNYNSQ TAFQVAIIAG NFELAEVIKT HKDSDVVPFR
360 370 380 390 400
ETPSYAKRRR LAGPSGLASP RPLQRSASDI NLKGEVQPAA SPGPSLRSLP
410 420 430 440 450
HQLLLQRLQE EKDRDRDGDQ ENDIGGPTAG RGSQRKIREL FPSGNLPEPG
460 470 480 490 500
KGGSLPTPPA SEQREGGGLR ASASVPSRKF IAVKAHSPQG EGEIPLHRGE
510 520 530 540 550
AVKVLSIGEG GFWEGTVKGR TGWFPADCVE EVQMRQYDTR HETREDRTKR
560 570 580 590 600
LFRHYTVGSY DSLTSHSDYV IDDKVAVLQK RDHEGFGFVL RGAKAETPIE
610 620 630 640 650
EFTPTPAFPA LQYLESVDVE GVAWRAGLRT GDFLIEVNGV NVVKVGHKQV
660 670 680 690 700
VALIRQGGNR LVMKVVSVTR KPEEDGARRR APPPPKRAPS TTLTLRSKSM
710 720 730 740 750
TAELEELASI RRRKGEKLDE ILAAAAEPAL RPDIADADSR AATVKQRPTS
760 770 780 790 800
RRITPAEISS LFERQGLPGP EKLPGSLRKG IPRTKSVGED EKLASLLEGR
810 820 830 840 850
FPRSTSMQDP VREGRGIPPP PQTAPPPPPA PYYFDSGPPP AFSPPPPPGR
860 870 880 890 900
AYDTVRSSFK PGLEARLGAG AAGLYDPGAP LGPLPYPERQ KRARSMIILQ
910 920 930 940 950
DSAPEMGDVP RPPPAATPPE RPKRRPRPPG PDSPYANLGA FSASIFAPSK
960 970 980 990 1000
PQRRKSPLVK QLQVEDAQER AALAVGSPGP TGGSFAREPS PTHRGPRPSG
1010 1020 1030 1040 1050
LDYGLADSPG LAFGGPGPSK DRRLEERRRS TVFLSVGAIE GSPPSADLPS
1060 1070 1080 1090 1100
LQPSRSIDER LLGTGPTAGR DLLLPSPVSA LKPLVSGPSL GPSGSTFIHP
1110 1120 1130 1140 1150
LTGKPLDPSS PLALALAARE RALASQAPSR SPTPVHSPDA DRPGPLFVDV
1160 1170 1180 1190 1200
QARDSERGAL ASPAFSPRSP AWVPVPARRE PEKAPREERK SPEDKKSMIL
1210 1220 1230 1240 1250
SVLDTSLQRP AGLIVVHATS NGQEPSGLAA EEERPGTPEL APTPTQSAVV
1260 1270 1280 1290 1300
AEPLASPRAQ PPGSAPPSEP GPGQGSSEEE PELVFAVNLP PAQLSSSDEE
1310 1320 1330 1340 1350
TREELARIGL VPPPEEFANG VLLATPLPGP GPSPTTVPGP ASGKPSSEPP
1360 1370 1380 1390 1400
PAPESAADSG VEEADTRSSS DPHLETTSTI STVSSMSTLS SESGELTDTH
1410 1420 1430 1440 1450
TSFADGHTFL LEKPPVPPKP KLKSPLGKGP VTFRDPLLKQ SSDSELMAQQ
1460 1470 1480 1490 1500
HHAASAGLAS AAGPARPRYL FQRRSKLWGD PVESRGLPGP EDDKPAVISE
1510 1520 1530 1540 1550
LSSRLQQLNK DTRSLGEEPA GGLGGLLDPA KKSPIAAARL FSSLGELSTI
1560 1570 1580 1590 1600
SAQRSPGGPG GGASYPVRPG GRYPVARRAP SPVKPASLER VEGLGRPFGL
1610 1620 1630 1640 1650
TPPTILKSSS LSIPHEPKEV RFVVRSVSAR SRSPSPSPLP SPAPGPGPXS
1660 1670 1680 1690 1700
KFDVGDWLES IHLGEHRDRF EDHEIEGAHL PALTKDDFVE LGVTRVGHRM
1710
NIERALRQLD GS
Length:1,712
Mass (Da):183,485
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6838EF0AEE154453
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01086301 Genomic DNA No translation available.
AEYP01086302 Genomic DNA No translation available.
AEYP01086303 Genomic DNA No translation available.
AEYP01086304 Genomic DNA No translation available.
AEYP01086305 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000001885; ENSMPUP00000001849; ENSMPUG00000001864

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01086301 Genomic DNA No translation available.
AEYP01086302 Genomic DNA No translation available.
AEYP01086303 Genomic DNA No translation available.
AEYP01086304 Genomic DNA No translation available.
AEYP01086305 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000001849

Genome annotation databases

EnsembliENSMPUT00000001885; ENSMPUP00000001849; ENSMPUG00000001864

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
KOG4375, Eukaryota
GeneTreeiENSGT00940000153561
HOGENOMiCLU_001824_2_0_1
InParanoidiM3XRZ9
OMAiCEDENGW

Family and domain databases

Gene3Di1.10.150.50, 1 hit
1.25.40.20, 2 hits
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF17820, PDZ_6, 1 hit
PF00536, SAM_1, 1 hit
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SM00228, PDZ, 1 hit
SM00454, SAM, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS50106, PDZ, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3XRZ9_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3XRZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 2, 2021
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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