UniProtKB - M3XN29 (M3XN29_MUSPF)
Protein
Submitted name:
cAMP responsive element binding protein 1
Gene
CREB1
Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Functioni
GO - Molecular functioni
- cAMP response element binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
- RNA polymerase II activating transcription factor binding Source: Ensembl
GO - Biological processi
- axonogenesis Source: Ensembl
- cellular response to hepatocyte growth factor stimulus Source: Ensembl
- cellular response to leukemia inhibitory factor Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- cellular response to zinc ion Source: Ensembl
- circadian rhythm Source: Ensembl
- lactation Source: Ensembl
- lung saccule development Source: Ensembl
- memory Source: Ensembl
- negative regulation of transcription by competitive promoter binding Source: Ensembl
- pituitary gland development Source: Ensembl
- positive regulation of cardiac muscle tissue development Source: Ensembl
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of hormone secretion Source: Ensembl
- positive regulation of lipid biosynthetic process Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- positive regulation of osteoclast differentiation Source: Ensembl
- protein phosphorylation Source: Ensembl
- protein stabilization Source: Ensembl
- regulation of cell size Source: Ensembl
- response to drug Source: Ensembl
- response to glucagon Source: Ensembl
- secretory granule organization Source: Ensembl
- type I pneumocyte differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: cAMP responsive element binding protein 1Imported |
Gene namesi | Name:CREB1Imported |
Organismi | Mustela putorius furo (European domestic ferret) (Mustela furo)Imported |
Taxonomic identifieri | 9669 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Mustelidae › Mustelinae › Mustela › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- ATF4-CREB1 transcription factor complex Source: Ensembl
- nuclear euchromatin Source: Ensembl
- nucleoplasm Source: Ensembl
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
- RNA polymerase II activating transcription factor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9668.ENSMPUP00000000479 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 160 | KIDInterPro annotationAdd BLAST | 60 | |
Domaini | 283 – 334 | BZIPInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 107 – 127 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 139 – 165 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 301 – 335 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3584, Eukaryota |
GeneTreei | ENSGT00940000155408 |
HOGENOMi | CLU_042675_0_1_1 |
InParanoidi | M3XN29 |
OMAi | QXISTIA |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR003102, Coactivator_CBP_pKID IPR029802, CREB1 IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF1, PTHR45879:SF1, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
PRINTSi | PR00041, LEUZIPPRCREB |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
i Sequence
Sequence statusi: Complete.
M3XN29-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMESGAENQ QSGDAAVTEA ESQQMTVQAQ PQIATLAQVS MPAAHATSSA
60 70 80 90 100
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT
110 120 130 140 150
QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR
160 170 180 190 200
IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG
210 220 230 240 250
VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ
260 270 280 290 300
TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC
310 320 330 340
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEYP01060567 Genomic DNA No translation available. |
RefSeqi | XP_004764314.1, XM_004764257.2 XP_012917740.1, XM_013062286.1 |
Genome annotation databases
Ensembli | ENSMPUT00000000490; ENSMPUP00000000479; ENSMPUG00000000485 |
GeneIDi | 101677618 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEYP01060567 Genomic DNA No translation available. |
RefSeqi | XP_004764314.1, XM_004764257.2 XP_012917740.1, XM_013062286.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9668.ENSMPUP00000000479 |
Genome annotation databases
Ensembli | ENSMPUT00000000490; ENSMPUP00000000479; ENSMPUG00000000485 |
GeneIDi | 101677618 |
Organism-specific databases
CTDi | 1385 |
Phylogenomic databases
eggNOGi | KOG3584, Eukaryota |
GeneTreei | ENSGT00940000155408 |
HOGENOMi | CLU_042675_0_1_1 |
InParanoidi | M3XN29 |
OMAi | QXISTIA |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR003102, Coactivator_CBP_pKID IPR029802, CREB1 IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit PTHR45879:SF1, PTHR45879:SF1, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
PRINTSi | PR00041, LEUZIPPRCREB |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3XN29_MUSPF | |
Accessioni | M3XN29Primary (citable) accession number: M3XN29 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2013 |
Last sequence update: | May 1, 2013 | |
Last modified: | October 7, 2020 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |