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Protein
Submitted name:

Leucine rich repeat kinase 2

Gene

LRRK2

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine rich repeat kinase 2Imported
Gene namesi
Name:LRRK2Imported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000000233

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1328 – 1511RocInterPro annotationAdd BLAST184
Domaini1879 – 2146Protein kinaseInterPro annotationAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili320 – 347Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
KOG0619 Eukaryota
COG1100 LUCA
COG4886 LUCA
GeneTreeiENSGT00910000144054
InParanoidiM3XMD3
OMAiFKIRDQP
OrthoDBiEOG091G003N

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.130.10.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR020859 ROC_dom
IPR008271 Ser/Thr_kinase_AS
IPR005225 Small_GTP-bd_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF16095 COR, 1 hit
PF12799 LRR_4, 1 hit
PF13855 LRR_8, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF50978 SSF50978, 2 hits
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51424 ROC, 1 hit

Sequencei

Sequence statusi: Complete.

M3XMD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSCQGCE EEDEETLKKL IVRLNNVQEG KQIETLVQIL EDMLVFTYAD
60 70 80 90 100
HASKLFQGKK VHVPVLIVLD LYMRVASVQQ VGWSLLCKLI EICPNTMQSL
110 120 130 140 150
MGPQDIGHDW EVLGVHQLIL KMLTVHNANV NLLTVGLKAL DLLLTSGKIT
160 170 180 190 200
LLILDEESDI FLLIFDAMRT FSANDEVQKL GCKALHVLFE RVSEEQLTEF
210 220 230 240 250
VENKDYIILL NALKNFKDEE EIVLHVLHCL HSLAIPCNNV EVLMSGNVRC
260 270 280 290 300
YNIVVEAMKT FPVNEKIQEV SCCLLHRLTL GNFFNILVLN EVHEFVVKAV
310 320 330 340 350
QRYSENATLQ IAALSCLALL TETIFLNQDL EEKNENQEND DEEEDKLFWL
360 370 380 390 400
EACYKALTWH RKNKHVQEAA CWALNNLLMY QSSLHEKIGD EDGQFPAHRE
410 420 430 440 450
VMLSMLMHSS SKEVFQASAN ALSTLLEQNV NFRKILLSKG IYLNVLELMQ
460 470 480 490 500
KHIHSPEVAE SGCKMLNHLF EGSNTTLDTM AAVAPKIITV MKSHETSLSV
510 520 530 540 550
QLEALRAVLH FIVPGMPEES GEDTEYQHKL NMVKRQCFKN DIHKLVLAAL
560 570 580 590 600
NKFIGNPGIQ KCGLKVISSI AHSPDALEVL SLEGAIDSVL HTLQMYPDDQ
610 620 630 640 650
EIQCLGLSLI GCLITKKNLC IGTGHLLAKI LVSSLQRFKD MAEVQIKGFQ
660 670 680 690 700
TILAILELSV SFSNLLVHHS FDSVIFHQMS SSIMEQKDQQ FLNLCCKCFA
710 720 730 740 750
KLVMDDELKS VLLERACDQN NSIMVECLLL LGADANGTKE ATSLICQVCE
760 770 780 790 800
KASSPKLVEL LLNGGSREQD VRKALAISIG KGDSQIISLL LRRLALDLAN
810 820 830 840 850
NSICLGGFCI GKIEPSWLGP LFPDKTSNLR KETNIGSTLA RMVLRYQMKS
860 870 880 890 900
SLEEGAASGS NGNFPEGVLD KFDEWTFIPD SYVDSVFGQS DDLDSEGSEG
910 920 930 940 950
SFLVKRKSNS ISVGEFYRDR ALQRCSPNLQ RHSNSLGPIF DHEDLLKQKR
960 970 980 990 1000
KMLSSDDSLR SSKLQSHMRH SDSISSLASE REYITSLDLS ANELRDIDAL
1010 1020 1030 1040 1050
SQKSGISGHL EHLEKLELHQ NALTSFPQQL CETLKCLTHL DLHSNKFTSF
1060 1070 1080 1090 1100
PYYLLKMNCI ANLDVSRNDI SPSVVLDPAV KCPTLKHFNL SYNQLSSFPE
1110 1120 1130 1140 1150
NLGDVVEKLE QLILEGNKIP EICSPLSLKE LKILNLSKNH ITSLSEDFLE
1160 1170 1180 1190 1200
ACPKVESFSA RMNYLAAMPL LPSSLTSLKL SQNRFTCVPE VILNLPHLRS
1210 1220 1230 1240 1250
LDMSSNEIEY LPSPAHWKSL NLRELLFSFN QISILDLSEK AYVWSRVEKL
1260 1270 1280 1290 1300
HLSHNKLKEI PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD
1310 1320 1330 1340 1350
ELRLNFDFKH IGCKAKDIIR FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL
1360 1370 1380 1390 1400
LQQLTKTKKS DLGVQSATVG IDVKDWPIQI RGKGKKDLIL NVWDFAGREE
1410 1420 1430 1440 1450
FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASSSPVILV
1460 1470 1480 1490 1500
GTHLDVSDEK QRKACISKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL
1510 1520 1530 1540 1550
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR
1560 1570 1580 1590 1600
KRLLQLVKEN QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP
1610 1620 1630 1640 1650
KWLCKVMAQI LTVKVEGYPK HPKGIISRRD VEKFLSKKKR FPKNYMSQYF
1660 1670 1680 1690 1700
KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF
1710 1720 1730 1740 1750
PMGFWSRLIN RLLEISPYML SGRERALRPN RMYWRQGIYL NWSPEAYCLV
1760 1770 1780 1790 1800
GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI
1810 1820 1830 1840 1850
CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI
1860 1870 1880 1890 1900
PISQIAPDLI LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRAAYEG
1910 1920 1930 1940 1950
EEVAVKIFNK HTSLRLLRQE LVVLCHLHHP SLISLLAAGI RPRMLVMELA
1960 1970 1980 1990 2000
SKGSLDRLLQ QDKGSLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV
2010 2020 2030 2040 2050
LLFTLYPNAG IIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY
2060 2070 2080 2090 2100
NQQADVYSFG LLLYDILTTG GRIAEGLKFP NEFDELAIQG KLPDPVKEYG
2110 2120 2130 2140 2150
CAPWPMVEKL IKKCLKENPQ ERPTSAQVFD ILNSAELICL MRHISIPKNF
2160 2170 2180 2190 2200
SVECMVATNH NSKNASIWLG CGHRDKGQLL FLDLNTEKQT SEEVIDSRIL
2210 2220 2230 2240 2250
CLALVPLPAE KESWIVCGTQ SGMLLVINTE DGDKRHTLGK MTDSVTCLYC
2260 2270 2280 2290 2300
NPFPKQSKQK NFLLVGTADG NLAIFEDKTV KCKGAAPLKI LNIGNVSTPL
2310 2320 2330 2340 2350
MCLSESMNSA EKNIVWGGCG TKLFSFSDDF TIQKLIETKT HQLFSYAAFS
2360 2370 2380 2390 2400
DSNIIAVVVD TALYVAKKNS PFVEVRDKKT EKLCELIDCV HFLKEEMVKV
2410 2420 2430 2440 2450
NAESKHKLSY TGRVKTLCLQ KNTALWIGTG GGHILLLDLS TRRIIRIIQN
2460 2470 2480 2490 2500
FCDSVRVMMT AQLGSLKNVM LVLGYIRKST ESSQHQKEIQ SCLSVWDINL
2510 2520
PHEVQNLEKH IEVRKELAEK MRRVSVE
Length:2,527
Mass (Da):285,345
Last modified:May 1, 2013 - v1
Checksum:iC8833174E9E07444
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01077657 Genomic DNA No translation available.
AEYP01077658 Genomic DNA No translation available.
AEYP01077659 Genomic DNA No translation available.
AEYP01077660 Genomic DNA No translation available.
AEYP01077661 Genomic DNA No translation available.
RefSeqiXP_004771900.1, XM_004771843.2

Genome annotation databases

EnsembliENSMPUT00000000237; ENSMPUP00000000233; ENSMPUG00000000236
GeneIDi101684592

Similar proteinsi

Entry informationi

Entry nameiM3XMD3_MUSPF
AccessioniPrimary (citable) accession number: M3XMD3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 20, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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