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UniProtKB - M3XI36 (M3XI36_LATCH)

Entry version 52 (02 Dec 2020)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

TDRD1

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Coelacanthiformes › Coelacanthidae › Latimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7897.ENSLACP00000022392

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 215MYND-typeInterPro annotationAdd BLAST37
Domaini318 – 378TudorInterPro annotationAdd BLAST61
Domaini556 – 615TudorInterPro annotationAdd BLAST60
Domaini773 – 831TudorInterPro annotationAdd BLAST59
Domaini987 – 1045TudorInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 42DisorderedSequence analysisAdd BLAST21
Regioni70 – 108DisorderedSequence analysisAdd BLAST39
Regioni129 – 151DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1140 – 1160Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 86PolarSequence analysisAdd BLAST17
Compositional biasi89 – 103PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2039, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158754

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010832_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		M3XI36

Identification of Orthologs from Complete Genome Data

More...OMAi		CCARFTG

Database of Orthologous Groups

More...OrthoDBi		703199at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.90, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR002893, Znf_MYND

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00567, TUDOR, 4 hits
PF01753, zf-MYND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00333, TUDOR, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50304, TUDOR, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M3XI36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSENQVNASS SLHQMLQNQN LDKTCPQPSL RSPRTHPNFK TKKPEIGVET 
        60         70         80         90        100
TGIFSKNFLF CEQSRPHFTN LSNPSRGCSS NGDGPEVNGT KKKLTEVRPK 
       110        120        130        140        150
PDLGEKSPTG QALQLQFYCG SSSSSLSSTE DVYTGAKPVS KPRRQQRHKI 
       160        170        180        190        200
RTTSESLASL NFEEKLFKSL SAPPRSTTCH NCGLFGSLRC SQCKQTYYCS 
       210        220        230        240        250
EKCQKKDWSA HSNICKPVKQ STKVEEVNRF PSEKLEDAKP KVDTTKEDLH 
       260        270        280        290        300
IKKKVNLSHF KNLGLTKGMQ IQVAVTDFKN PSHFFVQIHT EKTIDYLSKI 
       310        320        330        340        350
TLAMTDSYAD VNCHMEYIPE TGEVCVAKYT QDQNWYRALV QAVDQAQKKA 
       360        370        380        390        400
SILYIDYGNG EEISLDRIRP LLKEIELFPP CAVQCFIPNV TPVDGYWNEE 
       410        420        430        440        450
CINSVRQLLL GQPTVVTILD VLHNDTILVC CAVDIMFPNT GESLDKYLLK 
       460        470        480        490        500
KGYSSDQVNK NNMKTTMDFG VVMDKTLKEF REAKVLETVE KEECEDLQSP 
       510        520        530        540        550
QVISLSVGDV FSAVVADIQT PDVFFCQQLK SGRQLAELQA TLSEYCSRIP 
       560        570        580        590        600
ANPAFNPAVG TTCCAQFTED NQWYRASILG YSPEDTVLVG YIDYGNVEEV 
       610        620        630        640        650
LTRRLRPLQG SLLHLPVQAI KCALSGVKPP LETWSPEAIA VMKKLVSQKI 
       660        670        680        690        700
LEVRVTGTRE ENTAVVELLD KSVDPVVNVA EHLVSASWAA EEGEMSMTSN 
       710        720        730        740        750
ASLKKDVPTV NQAEYLKGKF SINQTMDVIM CFICSPGEFY CQCSNAEDLY 
       760        770        780        790        800
ALNGMNNSLN EYCCKLPPDD DFRPVKGEPC CAFFTSDGNW YRAMVKESFH 
       810        820        830        840        850
GTVMVYFVDY GNVEEITVEK LRPIHPQFLK LPVQAIKCSL AGVKPFNKEW 
       860        870        880        890        900
TTEAMAHFRA LTAGVQLHVK IVSTSENDVG VELTNSSSGT PLNIGEVLVK 
       910        920        930        940        950
KKLAVMETDQ AEVLLSEEHT DISSLEQWKT VELPLNETLS MLVMDVVNPG 
       960        970        980        990       1000
LFYALQFTVK VAEQKLYALM TDLAEYGSKQ SANTTFIPRI GEICCARFTG 
      1010       1020       1030       1040       1050
DNNWYRAIAL EASDVEVKVL YVDYGNVEIL QLSRILPIQP YHLELPFQII 
      1060       1070       1080       1090       1100
KCKLSGIEML AGKWLPAAKD LLRALLLNKE VKATVKEVHE NIHSVTIITE 
      1110       1120       1130       1140       1150
LENGCINVAD RLVMEGLAKY CSNNQMVLSQ EPSQHANCCC KELQEKVERH 
      1160       1170
EEILLFLLRK HIDPADFSQM
Length:1,170
Mass (Da):131,065
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEA494E1B1293591
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3AU05H3AU05_LATCH
Uncharacterized protein
TDRD1
1,154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AFYH01135375 Genomic DNA No translation available.
AFYH01135376 Genomic DNA No translation available.
AFYH01135377 Genomic DNA No translation available.
AFYH01135378 Genomic DNA No translation available.
AFYH01135379 Genomic DNA No translation available.
AFYH01135380 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_014348088.1, XM_014492602.1
XP_014348089.1, XM_014492603.1
XP_014348091.1, XM_014492605.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSLACT00000025202; ENSLACP00000022392; ENSLACG00000011559

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102361019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		lcm:102361019

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01135375 Genomic DNA No translation available.
AFYH01135376 Genomic DNA No translation available.
AFYH01135377 Genomic DNA No translation available.
AFYH01135378 Genomic DNA No translation available.
AFYH01135379 Genomic DNA No translation available.
AFYH01135380 Genomic DNA No translation available.
RefSeqiXP_014348088.1, XM_014492602.1
XP_014348089.1, XM_014492603.1
XP_014348091.1, XM_014492605.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000022392

Genome annotation databases

EnsembliENSLACT00000025202; ENSLACP00000022392; ENSLACG00000011559
GeneIDi102361019
KEGGilcm:102361019

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56165

Phylogenomic databases

eggNOGiKOG2039, Eukaryota
GeneTreeiENSGT00940000158754
HOGENOMiCLU_010832_0_0_1
InParanoidiM3XI36
OMAiCCARFTG
OrthoDBi703199at2759

Family and domain databases

Gene3Di2.40.50.90, 4 hits
InterProiView protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF00567, TUDOR, 4 hits
PF01753, zf-MYND, 1 hit
SMARTiView protein in SMART
SM00333, TUDOR, 4 hits
PROSITEiView protein in PROSITE
PS50304, TUDOR, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3XI36_LATCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3XI36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: December 2, 2020
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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