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Entry version 50 (05 Jun 2019)
Sequence version 3 (10 Oct 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK3

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome D2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSFCAG00000031392 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000025098

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 815ANK_REP_REGIONInterPro annotationAdd BLAST776
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 105ANKPROSITE-ProRule annotationAdd BLAST33
Repeati106 – 138ANKPROSITE-ProRule annotationAdd BLAST33
Repeati139 – 171ANKPROSITE-ProRule annotationAdd BLAST33
Repeati172 – 195ANKPROSITE-ProRule annotationAdd BLAST24
Repeati234 – 266ANKPROSITE-ProRule annotationAdd BLAST33
Repeati267 – 299ANKPROSITE-ProRule annotationAdd BLAST33
Repeati300 – 332ANKPROSITE-ProRule annotationAdd BLAST33
Repeati333 – 365ANKPROSITE-ProRule annotationAdd BLAST33
Repeati366 – 398ANKPROSITE-ProRule annotationAdd BLAST33
Repeati399 – 431ANKPROSITE-ProRule annotationAdd BLAST33
Repeati432 – 464ANKPROSITE-ProRule annotationAdd BLAST33
Repeati465 – 497ANKPROSITE-ProRule annotationAdd BLAST33
Repeati498 – 530ANKPROSITE-ProRule annotationAdd BLAST33
Repeati531 – 563ANKPROSITE-ProRule annotationAdd BLAST33
Repeati564 – 596ANKPROSITE-ProRule annotationAdd BLAST33
Repeati597 – 629ANKPROSITE-ProRule annotationAdd BLAST33
Repeati630 – 662ANKPROSITE-ProRule annotationAdd BLAST33
Repeati663 – 695ANKPROSITE-ProRule annotationAdd BLAST33
Repeati696 – 728ANKPROSITE-ProRule annotationAdd BLAST33
Repeati729 – 761ANKPROSITE-ProRule annotationAdd BLAST33
Repeati762 – 794ANKPROSITE-ProRule annotationAdd BLAST33
Domaini984 – 1139ZU5InterPro annotationAdd BLAST156
Domaini1141 – 1288ZU5InterPro annotationAdd BLAST148
Domaini4086 – 4170DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni1519 – 1540DisorderedSequence analysisAdd BLAST22
Regioni1608 – 1648DisorderedSequence analysisAdd BLAST41
Regioni2107 – 2160DisorderedSequence analysisAdd BLAST54
Regioni2172 – 2263DisorderedSequence analysisAdd BLAST92
Regioni2300 – 2322DisorderedSequence analysisAdd BLAST23
Regioni2378 – 2433DisorderedSequence analysisAdd BLAST56
Regioni2474 – 2508DisorderedSequence analysisAdd BLAST35
Regioni2589 – 2751DisorderedSequence analysisAdd BLAST163
Regioni2798 – 2820DisorderedSequence analysisAdd BLAST23
Regioni2938 – 3014DisorderedSequence analysisAdd BLAST77
Regioni3035 – 3072DisorderedSequence analysisAdd BLAST38
Regioni3130 – 3268DisorderedSequence analysisAdd BLAST139
Regioni3298 – 3519DisorderedSequence analysisAdd BLAST222
Regioni3543 – 3611DisorderedSequence analysisAdd BLAST69
Regioni3639 – 3721DisorderedSequence analysisAdd BLAST83
Regioni3873 – 3898DisorderedSequence analysisAdd BLAST26
Regioni4015 – 4087DisorderedSequence analysisAdd BLAST73
Regioni4247 – 4275DisorderedSequence analysisAdd BLAST29
Regioni4319 – 4374DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 27PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1610 – 1648PolarSequence analysisAdd BLAST39
Compositional biasi2112 – 2129PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2130 – 2146PolarSequence analysisAdd BLAST17
Compositional biasi2184 – 2201Pro-richSequence analysisAdd BLAST18
Compositional biasi2219 – 2248PolyampholyteSequence analysisAdd BLAST30
Compositional biasi2403 – 2433PolarSequence analysisAdd BLAST31
Compositional biasi2589 – 2618PolyampholyteSequence analysisAdd BLAST30
Compositional biasi2619 – 2636PolarSequence analysisAdd BLAST18
Compositional biasi2645 – 2672PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2680 – 2697PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2699 – 2721PolarSequence analysisAdd BLAST23
Compositional biasi2731 – 2749PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2989 – 3007PolarSequence analysisAdd BLAST19
Compositional biasi3042 – 3059PolarSequence analysisAdd BLAST18
Compositional biasi3130 – 3186PolarSequence analysisAdd BLAST57
Compositional biasi3225 – 3243PolyampholyteSequence analysisAdd BLAST19
Compositional biasi3334 – 3358PolyampholyteSequence analysisAdd BLAST25
Compositional biasi3378 – 3408PolarSequence analysisAdd BLAST31
Compositional biasi3465 – 3499PolyampholyteSequence analysisAdd BLAST35
Compositional biasi3549 – 3573PolyampholyteSequence analysisAdd BLAST25
Compositional biasi3580 – 3603PolarSequence analysisAdd BLAST24
Compositional biasi3654 – 3676PolarSequence analysisAdd BLAST23
Compositional biasi3690 – 3720PolarSequence analysisAdd BLAST31
Compositional biasi4015 – 4030PolyampholyteSequence analysisAdd BLAST16
Compositional biasi4031 – 4048PolarSequence analysisAdd BLAST18
Compositional biasi4049 – 4072PolyampholyteSequence analysisAdd BLAST24
Compositional biasi4260 – 4274PolarSequence analysisAdd BLAST15
Compositional biasi4334 – 4348PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154939

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3XEN9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 7 hits
cd08803 Death_ank3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037971 Ank3_Death
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 6 hits
PF13606 Ank_3, 1 hit
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

M3XEN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAASQLKK NRDLEINAEE ETEKKRKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVKFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH IAAHYGNINV
260 270 280 290 300
ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
310 320 330 340 350
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV
360 370 380 390 400
QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG
410 420 430 440 450
FTPLHIACKK NRIKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS
460 470 480 490 500
QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ
510 520 530 540 550
TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA REGHEDVAAF
560 570 580 590 600
LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT
610 620 630 640 650
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL
660 670 680 690 700
LEYGADANAV TRQGIASVHL AAQEGHVDMV SLLLSRNANV NLSNKNGLTP
710 720 730 740 750
LHLAAQEDRV NVAEVLVNQG ANVDAQTKMG YTPLHVGCHY GNIKIVNFLL
760 770 780 790 800
QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN VLLQNNASPN ELTVNGNTAL
810 820 830 840 850
AIARRLGYIS VVDTLKVVTE ETMTTTTIIE KHKMNVPETM NEVLDMSDDE
860 870 880 890 900
VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE
910 920 930 940 950
GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT
960 970 980 990 1000
FTREFDSDSL RHYSWAADTL DNVNLVSSPV HSGFLVSFMV DARGGSMRGS
1010 1020 1030 1040 1050
RHHGMRIIIP PRKCTAPTRI TCRLVKRHKL ANPPPMVEGE GLASRLVEMG
1060 1070 1080 1090 1100
PAGAQFLGPV IVEIPHFGSM RGKERELIVL RSENGETWKE HQFDSKNEDL
1110 1120 1130 1140 1150
TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI KQESNQIGPE
1160 1170 1180 1190 1200
GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS
1210 1220 1230 1240 1250
PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG
1260 1270 1280 1290 1300
GTSPAQWEDI TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLASQ
1310 1320 1330 1340 1350
LYRELICVPY MAKFVVFAKM NDPVESSLRC FCMTDDKVDK TLEQQENFEE
1360 1370 1380 1390 1400
VARSKDIEVL EGKPIYVDCY GNLAPLTKGG QQLVFNFYAF KENRLPFSIK
1410 1420 1430 1440 1450
IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK KETESDQDDE
1460 1470 1480 1490 1500
AEKADRRQSF ASLALRKRYS YLTEPGMIER SAGATRSLPT TYSYKPFFST
1510 1520 1530 1540 1550
RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK
1560 1570 1580 1590 1600
STLGASTTSS VKSISDVASP IRSFRTISSP IKTVVSQSPY NIQVSSGTLV
1610 1620 1630 1640 1650
RAPTVPESSP LKGLASNSTF SSRTSPVTTA GSLLERSSIT MTPPASPKSN
1660 1670 1680 1690 1700
INMYSSSLPF KSIITSAAPL ISSPLKSVVS PVKSAVDVIS SAKVTMAPSL
1710 1720 1730 1740 1750
SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT LQEKISTATN
1760 1770 1780 1790 1800
SVSSVVSAAT DTVDKVFSTT TAMPFSPLRS YVSSAPSAFQ SLRTPSASAL
1810 1820 1830 1840 1850
YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSSSLTKSAA
1860 1870 1880 1890 1900
ALLSPIKTLT TETRPQPHFN RTSSPVKSSL FLAPSALKLS TPSSLSSSQE
1910 1920 1930 1940 1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ PELPKEGRID DEEPFKIVEK
1960 1970 1980 1990 2000
VKEDLVKVSE ILKKDVCVDN KGPPKSPKSD KGLSPEDDWI EFSSEEIREA
2010 2020 2030 2040 2050
RQQAATIHSP TLPERVQVKA KAASEKDYNL TKVIDYLTND IGSSSLTNLK
2060 2070 2080 2090 2100
YKFEDAKKDG EERQKRILKP AIALQEHKLK MPPASMRPST SEKELCKMAD
2110 2120 2130 2140 2150
SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK
2160 2170 2180 2190 2200
PLFHEVPIPP VITETRTEVV HVIRSYEPSA GDAPPGQPEE PVSPKPSPTF
2210 2220 2230 2240 2250
TELEPKPTTS SIKEKVKAFQ MKANGEEDDH SRVLSKGMRV KEETHITTTT
2260 2270 2280 2290 2300
RMVYHSPPGS EGASERIEET MSVHDIMKAF QSGRDPSKEL AGLFEHKSAV
2310 2320 2330 2340 2350
PPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA EPTEVIIRET
2360 2370 2380 2390 2400
KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE
2410 2420 2430 2440 2450
ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD
2460 2470 2480 2490 2500
DELSELRGES YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK
2510 2520 2530 2540 2550
RSREKVVTAP KKEILSKIYK DVSENGVGKV SKDEHFDKVT VLHYSGDVSS
2560 2570 2580 2590 2600
PKHAMWMRFT EDRLDRGREK LIYEDRVDRT VKEAEEKLTE VSQFFRDKTE
2610 2620 2630 2640 2650
KLNDELQSPE KKPRPRNGKE YSSQSSTSSS PEKVLLTELL ASNDEWVKAR
2660 2670 2680 2690 2700
QHGHDGQGFP KADERKESSL PSSPEKKVLS QQPEDSKSME EAKESISQSK
2710 2720 2730 2740 2750
APEGPQSGFQ LKQSKLSSIR LKFEQGAQAK SKDMSQEDKK PEGQSRIPVK
2760 2770 2780 2790 2800
KIQESKLPVY QVFAREKQQK AIDLPDESVS VQNDFMVLKA KDEHVQSNEI
2810 2820 2830 2840 2850
VINDSGSEDV KTQRTEMSSK AMPDYFSEQQ AKDLACHVTS DLATKGPWDK
2860 2870 2880 2890 2900
KVFRTWESSG AANNKSQKEK LSHVLVHDVR ENHIGHPESK IVDQRSEFMS
2910 2920 2930 2940 2950
VTEREHKLLT NGSLSEIKEM TVKSPSKKVL YREYVVKEGE RPGGSLEQPS
2960 2970 2980 2990 3000
RRSESSAASH IPVRAAEGRR ILSSDIPDGF CEQPTFPQHE LSPKLSPSSM
3010 3020 3030 3040 3050
SKETVETQHF NSIEDEKVTY SEISKVSKRQ SYVGLCPPLD ETETSPTKSP
3060 3070 3080 3090 3100
DSLEFSPGKE SPSSDVFDHS PLDGLERVAP LAQTEGGKDI KTLPVYVSFV
3110 3120 3130 3140 3150
QVGKQYEKEI QQGSVKKIIS QECKTVQETR GTFYTTRQQK QPPSPQGSPE
3160 3170 3180 3190 3200
DDTLEQVSFL DSSGKSPLTP ETPSSEEVSY EFTSKTPDSL IAYIPGKPSP
3210 3220 3230 3240 3250
IPEVSEESEE EEQAKSASLK QTTVEEATVE REMPTDASKD SNQRPKTSRV
3260 3270 3280 3290 3300
AYIEFPPPPP LDADQMEPDK KHHYLPEREV DMIEVSLQDE HDKYQLAEPV
3310 3320 3330 3340 3350
IRVQPPSPVP PGADVSDSSD DESIYQPVPV KKYTFKLKEV DDEQKEMTKS
3360 3370 3380 3390 3400
KAPADKASNQ KELETNGSGK DNEFGLGLDS PQNETAQNGN NDQSITECSI
3410 3420 3430 3440 3450
ATTAEFSHDT DATEIDSLDG YDLQDEDDGL TESDSKLPSQ TMEIKKDVWN
3460 3470 3480 3490 3500
TEGILKPADR SFSQSKLEVI EEEEGRVGPD EDKPPSKSSS SERTPDKTDQ
3510 3520 3530 3540 3550
KSGAQFFTLE GRHPDRSVFP DTYFSYKVDE EFATPFKTVA TKGLDFDPWS
3560 3570 3580 3590 3600
NNRGDDEVFD SKSREDETKP FGLAVEDRSP ATTPDTTPAR TPTDESTPTS
3610 3620 3630 3640 3650
EPNPFPFHEG KMFEMTRSGA IDMSKRDFVE ERLQFFQIGE HTSEGKSGDQ
3660 3670 3680 3690 3700
GEGDKSMVTA TPQPQSGDTT VETNLERNVE APPVEPNPSI PTSGECQEGT
3710 3720 3730 3740 3750
SSSGSLEKSA AATSTSKVDP KLRTPIKMGI SASTMTMKKE GPGEVTDKIE
3760 3770 3780 3790 3800
AVMTSCQGLE NETIPMISNT ANSHMGTRPQ EKHDFQKDNF NNNNNLDSST
3810 3820 3830 3840 3850
IQTDNITSNI VLTEHSAPTC TTEKANPVKI SSGKKTGVLQ GHCVRDKQKV
3860 3870 3880 3890 3900
LGEQPKTKES IGIRRKSKLP IKATSPKDIC PPSHMPNMKV SKTKQVSQSE
3910 3920 3930 3940 3950
KTKTLISSSC VDVKSRIPVK DTHRDNVVRK ACATQKQGQP EKGKAKQLPS
3960 3970 3980 3990 4000
KLPVKVRSTC VTTTTTTTTT TTTTAAIVKV RKSQLKEVCK HSIEYFKGIS
4010 4020 4030 4040 4050
GETLKLVDRL SEEDKKMQSE LSDEEDSTSR NTSLSETSRG GQPSVTTKSA
4060 4070 4080 4090 4100
RDKKTEAAPL KSKSEKAGSG KRSSRRTGPQ SPCERTDIRM AIVADHLGLS
4110 4120 4130 4140 4150
WTELARELNF SVDEINQIRV ENPNSLISQS FMLLKKWVTR DGKNATTDAL
4160 4170 4180 4190 4200
TSVLTKINRI DIVTLLEGPI FDYGNISGTR SFADENNVFH DPVDGWQNET
4210 4220 4230 4240 4250
SGGNLESPAQ ARRLTGGLLE RLDDSPDQCR DSITSYLKGE PGKFEANGSH
4260 4270 4280 4290 4300
AEVTPEAKTK SYFPESQNDI GKQSAKETLK PKIHGSGRVE EPASSLAAYQ
4310 4320 4330 4340 4350
KALEETSKFV IEEPKPCVPV SMKKMSRTSP ADGKPRLNLH EEEGSSGSEQ
4360 4370
KQGEGYKVKT AKKEIRHVEK KSHS
Length:4,374
Mass (Da):479,941
Last modified:October 10, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA347276382D7C539
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2U9C8A0A2I2U9C8_FELCA
Uncharacterized protein
ANK3
1,863Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2U574A0A2I2U574_FELCA
Uncharacterized protein
ANK3
1,870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2UPN7A0A2I2UPN7_FELCA
Uncharacterized protein
ANK3
1,003Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A337SFG0A0A337SFG0_FELCA
Uncharacterized protein
ANK3
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2ULT5A0A2I2ULT5_FELCA
Uncharacterized protein
ANK3
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AANG04000273 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSFCAT00000032393; ENSFCAP00000025098; ENSFCAG00000031392

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04000273 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000025098

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000032393; ENSFCAP00000025098; ENSFCAG00000031392

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000154939
InParanoidiM3XEN9

Gene expression databases

BgeeiENSFCAG00000031392 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00204 ANK, 7 hits
cd08803 Death_ank3, 1 hit
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR037971 Ank3_Death
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 6 hits
PF13606 Ank_3, 1 hit
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3XEN9_FELCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3XEN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: October 10, 2018
Last modified: June 5, 2019
This is version 50 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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