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Entry version 49 (31 Jul 2019)
Sequence version 2 (10 Oct 2018)
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Protein

ANK_REP_REGION domain-containing protein

Gene

BCORL1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ANK_REP_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCORL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:60093 BCORL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSFCAG00000031869 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000019374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1428 – 1531ANK_REP_REGIONInterPro annotationAdd BLAST104
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1457 – 1489ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1490 – 1522ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 101DisorderedSequence analysisAdd BLAST38
Regioni113 – 135DisorderedSequence analysisAdd BLAST23
Regioni341 – 368DisorderedSequence analysisAdd BLAST28
Regioni528 – 646DisorderedSequence analysisAdd BLAST119
Regioni754 – 782DisorderedSequence analysisAdd BLAST29
Regioni869 – 903DisorderedSequence analysisAdd BLAST35
Regioni939 – 974DisorderedSequence analysisAdd BLAST36
Regioni1111 – 1214DisorderedSequence analysisAdd BLAST104
Regioni1226 – 1296DisorderedSequence analysisAdd BLAST71
Regioni1314 – 1382DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 97PolyampholyteSequence analysisAdd BLAST19
Compositional biasi528 – 542PolarSequence analysisAdd BLAST15
Compositional biasi587 – 602PolarSequence analysisAdd BLAST16
Compositional biasi622 – 636PolarSequence analysisAdd BLAST15
Compositional biasi1122 – 1137PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1190 – 1214PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1278 – 1296PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1342 – 1377PolyampholyteSequence analysisAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFKH Eukaryota
ENOG411028G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3WYD4

Database of Orthologous Groups

More...
OrthoDBi
85469at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032365 PUFD
IPR038227 PUFD_som_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF16553 PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M3WYD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQRFGSQE
60 70 80 90 100
FCVSSSFSKV ELTAVGSGSN ARGADPDGNA AEKLGHKSED KPDDPQPKMD
110 120 130 140 150
YAGSVAEAEG LLVPLSSPRD GLKLTTPDSA DAANSRADCS WAPLGTQMSK
160 170 180 190 200
QTDCSAAGVK ALDSRHGVGE KNTFILATLG TGVPVEGTLP LVPTNFSPLP
210 220 230 240 250
APICPPAPSS ASVPPSVPDP FQVPLSVPTP VPHSGLVPVQ VATSVPAPSP
260 270 280 290 300
PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP
310 320 330 340 350
APTPLSVPVS APPLALIQAP VPPSAPTLVL TPVPTPVLAP MPASTPPAAP
360 370 380 390 400
APPSVPMPTP TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA
410 420 430 440 450
TPAAIPTSAP IPASFSLSRV CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV
460 470 480 490 500
YIPPPSCGQP LSMATLPTTL GVSSTLTLPV LPSYLQDRCL PGVLASPELR
510 520 530 540 550
SYPYAFSVAR PLTSDSKLVS LEVNRLPCAS PSSSTSTQSA PDGVPGPLAD
560 570 580 590 600
TSLSTASAKV LPTPQPLLPA PSVSSAPPHP AKMTGGAEQQ TEGTSVTFSP
610 620 630 640 650
LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV
660 670 680 690 700
HTSSKALLST VLSRSQRTTQ AAGSNVTSCL GSTSSPFVIF PDIVRNGDPS
710 720 730 740 750
TWVKNSTALI STIPGTYVGV ANPVPASLLL NKDPNLGLNR DPRHLPKQEP
760 770 780 790 800
ISIIDQGEPK STGAPCGKKG SQAGTEGQSS TVKRYTPARI APGLPGCQTK
810 820 830 840 850
ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQTS LLSIGISSAG
860 870 880 890 900
QLTPSQGVPI RPTSVVSEFS GVSPLSPSEA VHGLPEGQPR PGGPFAPEQD
910 920 930 940 950
TGTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS SGDIKVNQGP
960 970 980 990 1000
EESESHLCPD STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP
1010 1020 1030 1040 1050
QNLHKMPELP LLPHDSRPKE LIMDVVPSSK RGSGTELSQL GSQVDLGRVK
1060 1070 1080 1090 1100
MEKVDGDVVF NLATCFRTDG LPAAPQRGQA EVRNKAGQAR VKQESVGVFA
1110 1120 1130 1140 1150
CKNKWQPDSV VTDGVTESLP PKKMKFGKEK DAEEQQPQTK VIVRSSHGPK
1160 1170 1180 1190 1200
CRKPPSDPQE PTKKSPRGAS DSGKEHNRVR VKHKHRKPTK PDSQSPGKRA
1210 1220 1230 1240 1250
DGHEEGSLEK KAKSSFRDFI PVVLSTRTRS QSGSICSSFA GMADSDMGSQ
1260 1270 1280 1290 1300
EVFPTEEEED VTPTPAKRRK VRKTQRDTQY RSHHAQDKTL LSQGRRHLWR
1310 1320 1330 1340 1350
AREMPWRTEA ARQMWDTNEE EEEDEEEGLV KRKKRRRQKS RKYQTGEYLT
1360 1370 1380 1390 1400
EQEEEQRRKG RADLKARKQK TSSQSSEHRL RNRNLLLPSK AQGISDSPNG
1410 1420 1430 1440 1450
FLPNNLEEPA CLENSEKPSG KRKCKTKHMA NVSEEAKDVV LYCLQKDSED
1460 1470 1480 1490 1500
VNHRDNAGYT ALHEACSRGW TDILNILLEH GANVNCSAQD GTRPVHDAVV
1510 1520 1530 1540 1550
NDNLETIWLL LSYGADPTLA TYSGQTAMKL ASSDTMKRFL SDHLSDLQGR
1560 1570 1580 1590 1600
AEGDPGVSWD FYSSSVLEEK DGFACDLLHN PPGNSDQEGD DVEEDDFMFE
1610 1620 1630 1640 1650
LSDKPLLPCY NLQVSVSRGP CNWFLFTDVL KRLKLSSRIF QARFPHFEIA
1660 1670 1680 1690 1700
TLPKAEFYRQ VASSQLLTPA ERPGGMDDRS APGSSETVEL VRYEPELLRL
1710
LGSEVEFQPW NS
Length:1,712
Mass (Da):182,730
Last modified:October 10, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i110935B82BE66F10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2U5H3A0A2I2U5H3_FELCA
ANK_REP_REGION domain-containing pr...
BCORL1
1,786Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2U2A7A0A2I2U2A7_FELCA
ANK_REP_REGION domain-containing pr...
BCORL1
1,656Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AANG04002924 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSFCAT00000025589; ENSFCAP00000019374; ENSFCAG00000031869

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04002924 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000019374

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000025589; ENSFCAP00000019374; ENSFCAG00000031869

Organism-specific databases

VGNCiVGNC:60093 BCORL1

Phylogenomic databases

eggNOGiENOG410IFKH Eukaryota
ENOG411028G LUCA
GeneTreeiENSGT00940000153737
InParanoidiM3WYD4
OrthoDBi85469at2759

Gene expression databases

BgeeiENSFCAG00000031869 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032365 PUFD
IPR038227 PUFD_som_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF16553 PUFD, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3WYD4_FELCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3WYD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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