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UniProtKB - M3WUL4 (M3WUL4_FELCA)

Entry version 48 (12 Aug 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

TSC22 domain family member 1

Gene

TSC22D1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TSC22 domain family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSC22D1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome A1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:66607, TSC22D1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSFCAG00000025840, Expressed in uterus and 10 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9685.ENSFCAP00000018051

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 111DisorderedSequence analysisAdd BLAST89
Regioni126 – 265DisorderedSequence analysisAdd BLAST140
Regioni455 – 477DisorderedSequence analysisAdd BLAST23
Regioni903 – 933DisorderedSequence analysisAdd BLAST31
Regioni1028 – 1063DisorderedSequence analysisAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili986 – 1020Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 60PolarSequence analysisAdd BLAST25
Compositional biasi61 – 85Pro-richSequence analysisAdd BLAST25
Compositional biasi86 – 100PolarSequence analysisAdd BLAST15
Compositional biasi173 – 189PolarSequence analysisAdd BLAST17
Compositional biasi217 – 241BasicSequence analysisAdd BLAST25
Compositional biasi250 – 265PolarSequence analysisAdd BLAST16
Compositional biasi915 – 933PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4797, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159144

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		M3WUL4

Database of Orthologous Groups

More...OrthoDBi		1602203at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000580, TSC-22_Dip_Bun

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01166, TSC22, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01289, TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M3WUL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHQPPESTAA AAAAAADISA RKMAHPAMFP RRGSGSGSAS ALNAAGTGVG 
        60         70         80         90        100
SSATSSEDFP PPSLLQPPPP AASSTSGPQP PPPQSLNLLS QAQLQAQPLA 
       110        120        130        140        150
PGGTQMKKKS GFQITSVTPA QISASISSNN SIAEDTESYD DLDESHTEDL 
       160        170        180        190        200
SSSEILDVSL SRATDLGEPE RSSSEETLNN FQEAETPGAV SPNQPHLPQP 
       210        220        230        240        250
HLPHLPQQNV VINGNAHPHH LHHHHHIHHG HHLHHGHHHP SHAGVASTSI 
       260        270        280        290        300
PGGPPSSPVS RKLSAAGSSD SVLAAAPTSA VSSGGSPASV MTNIRAPSTT 
       310        320        330        340        350
GSIGISSVTG TNTMSNVTIT AVGSFNPSVT SSILGNANIN ASNIPSAATV 
       360        370        380        390        400
SVGPGVSSSV NVNILSGMGN GTISSSAVVN SAPSAAAGMT AGSLSGQQQP 
       410        420        430        440        450
PTVNTSRFRV VKLDSSSEPF KKGRWTCTEF YEKENAVPAA EGVAINKVVE 
       460        470        480        490        500
TVKQNPTEVT SERESTSGSS VSSSVSTLSH YTESVGSGEM GAPTVVVQQQ 
       510        520        530        540        550
QQPALQGMAL PQMDFSSTGP QSISAVSIPQ SISQSQITQV QLQSQELSYP 
       560        570        580        590        600
QKQGLQPVPL QATISAATGI QPSPVSVVGV TSALGQQPSI SSLAQPQLPY 
       610        620        630        640        650
SQTVPPVQAP LPGAPPQQLQ YGQQQPTVST QMVPGHGKSV AQNPSEYVQQ 
       660        670        680        690        700
QPILQTAVSS GQPSSAGVGA GATVIPTAQP QSIQLPVQPT AIQAQPAGAS 
       710        720        730        740        750
GQPVGQAQTA VSVVPTGSQI ANIGQQANIP TAVQQPSTQV TPSVIQQGAP 
       760        770        780        790        800
PSSQIVPPAQ TAIIHQGVQT SASSLPQQLV IAPQSTLLTV PPQPQGVESV 
       810        820        830        840        850
AQVVSQPLPA VSPLPSASSI SVTSQVSSTG PSGMPSAPTN LVPPQNIAQT 
       860        870        880        890        900
PATQNGNLVQ SVSQPPLIAS NINLPLAQQI PLSSTQFTAQ SLAQAIGSQI 
       910        920        930        940        950
EDARRPAEPS LVGLPQTISG DSGGMSAVSD GSSSSLAAPA SLFPLKVLPL 
       960        970        980        990       1000
TTPLVDGEDE SSSGASVVAI DNKIEQAMDL VKSHLMYAVR EEVEVLKEQI 
      1010       1020       1030       1040       1050
KELIEKNSQL EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA TTQPQGTTQP 
      1060 
PAQPASQGSG PTA
Length:1,063
Mass (Da):108,191
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i030F40378E39F3CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2UVA2A0A2I2UVA2_FELCA
TSC22 domain family member 1
TSC22D1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A337SAD4A0A337SAD4_FELCA
TSC22 domain family member 1
TSC22D1
1,080Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AANG04001781 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_011289561.1, XM_011291259.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSFCAT00000027317; ENSFCAP00000018051; ENSFCAG00000025840

Database of genes from NCBI RefSeq genomes

More...GeneIDi		101085595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		fca:101085595

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04001781 Genomic DNA No translation available.
RefSeqiXP_011289561.1, XM_011291259.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000018051

Genome annotation databases

EnsembliENSFCAT00000027317; ENSFCAP00000018051; ENSFCAG00000025840
GeneIDi101085595
KEGGifca:101085595

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8848
VGNCiVGNC:66607, TSC22D1

Phylogenomic databases

eggNOGiKOG4797, Eukaryota
GeneTreeiENSGT00940000159144
InParanoidiM3WUL4
OrthoDBi1602203at2759

Gene expression databases

BgeeiENSFCAG00000025840, Expressed in uterus and 10 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000580, TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166, TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289, TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3WUL4_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3WUL4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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