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Protein

Non-specific serine/threonine protein kinase

Gene

PAK4

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central
  • Rac GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:PAK4Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome E2

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSFCAG00000029229 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000017443

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
GeneTreeiENSGT00930000150829
InParanoidiM3WSV7
KOiK05734
OrthoDBiEOG091G0OT5

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M3WSV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGKKKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP
60 70 80 90 100
KPLVDPACIT SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL
110 120 130 140 150
RRDSPPPPAR AHQENGMPAE PASTARGAPE RAGGQGRVAG RSEAGGGSGD
160 170 180 190 200
RRRAGPEKRP KSSREGSGGP QESSRDKRPL SGPDVGTPQP AGLASGAKVA
210 220 230 240 250
AGRPFNTYPR ADTDHPSRGA QGEPHDLAPN GPSAGGRAVP QSSSSRPPTR
260 270 280 290 300
ARGPPSPGVL GPHASEPQLA PPARPVTTPA VPPAPGPPGP RSPQREPQRV
310 320 330 340 350
SHEQFRAALQ LVVDPGDPRS YLDNFIKIGE GSTGIVCIAT VRSSGRLVAV
360 370 380 390 400
KKMDLRKQQR RELLFNEVVI MRDYQHENVV EMYNSYLVGD ELWVVMEFLE
410 420 430 440 450
GGALTDIVTH TRMNEEQIAA VCLAVLQALS VLHAQGVIHR DIKSDSILLT
460 470 480 490 500
HDGRVKLSDF GFCAQVSKEV PRRKSLVGTP YWMAPELISR LPYGPEVDIW
510 520 530 540 550
SLGVMVIEMV DGEPPYFNEP PLKAMKMIRD NLPPRLKNLH KVSPSLKGFL
560 570 580 590
DRLLVRDPAQ RATAAELLKH PFLAKAGPPA SIVPLMRQNR TR
Length:592
Mass (Da):64,251
Last modified:October 10, 2018 - v3
Checksum:iA623FACD35738DD8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A337SMX5A0A337SMX5_FELCA
Non-specific serine/threonine prote...
PAK4
439Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04000747 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSFCAT00000025651; ENSFCAP00000017443; ENSFCAG00000029229
KEGGifca:101098348

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04000747 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000017443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000025651; ENSFCAP00000017443; ENSFCAG00000029229
KEGGifca:101098348

Organism-specific databases

CTDi10298

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
GeneTreeiENSGT00930000150829
InParanoidiM3WSV7
KOiK05734
OrthoDBiEOG091G0OT5

Gene expression databases

BgeeiENSFCAG00000029229 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM3WSV7_FELCA
AccessioniPrimary (citable) accession number: M3WSV7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: October 10, 2018
Last modified: November 7, 2018
This is version 45 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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