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Protein
Submitted name:

Paxillin

Gene

PXN

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
PaxillinImported
Gene namesi
Name:PXNImported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome D3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSFCAG00000018405 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000015977

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 414LIM zinc-bindingInterPro annotationAdd BLAST60
Domaini415 – 472LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini473 – 532LIM zinc-bindingInterPro annotationAdd BLAST60
Domaini533 – 590LIM zinc-bindingInterPro annotationAdd BLAST58

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00760000118910
InParanoidiM3WPB0
OrthoDBiEOG091G05AW

Family and domain databases

InterProiView protein in InterPro
IPR001904 Paxillin
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM
PANTHERiPTHR24216:SF11 PTHR24216:SF11, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
PIRSFiPIRSF037881 Leupaxin, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

M3WPB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP
60 70 80 90 100
PPPSSEALNG TILDPLDQWQ PSASRFIHQQ PQSPSPVYGS SAKTSSASVP
110 120 130 140 150
QDGGGPPCPR AGEEEHVYSF PNKQKSAEPS PTVMSSSLGS NLSELDRLLL
160 170 180 190 200
ELNAVQHNPP GFPADEANSS PPLPGALSPH CGIPENNSPL GGKAGPLTKE
210 220 230 240 250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EVSSPQRATS
260 270 280 290 300
SQQQTRMSAS SATRELDELM ASLSDFKIQG LEQIADGEAW AAGWPPNGRQ
310 320 330 340 350
SSPEGQDEGG FMAQGKTGSS SPPGGPPKPG SQLDSMLGSL QSDLNKLGVA
360 370 380 390 400
TVAKGVCGAC KKPIAGQVVT AMGKTWHPEH FVCTHCQEEI GSRNFFERDG
410 420 430 440 450
QPYCEKDYHN LFSPRCYYCN GPILDKVVTA LDRTWHPEHF FCAQCGAFFG
460 470 480 490 500
PEGFHEKDGK AYCRKDYFDM FAPKCGGCAR AILENYISAL NTLWHPECFV
510 520 530 540 550
CRECFTPFVN GSFFEHDGQP YCEVHYHERR GSLCSGCQKP ITGRCITAMA
560 570 580 590
KKFHPEHFVC AFCLKQLNKG TFKEQNDKPY CQNCFLKLFC
Length:590
Mass (Da):64,149
Last modified:October 10, 2018 - v3
Checksum:i567EB210B63AA37C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2UDM0A0A2I2UDM0_FELCA
Paxillin
PXN
585Annotation score:
A0A2I2UF54A0A2I2UF54_FELCA
Paxillin
PXN
557Annotation score:
A0A2I2UVY9A0A2I2UVY9_FELCA
Paxillin
PXN
1,081Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04002472 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSFCAT00000018548; ENSFCAP00000015977; ENSFCAG00000018405

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04002472 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000015977

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000018548; ENSFCAP00000015977; ENSFCAG00000018405

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00760000118910
InParanoidiM3WPB0
OrthoDBiEOG091G05AW

Gene expression databases

BgeeiENSFCAG00000018405 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR001904 Paxillin
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM
PANTHERiPTHR24216:SF11 PTHR24216:SF11, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
PIRSFiPIRSF037881 Leupaxin, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiM3WPB0_FELCA
AccessioniPrimary (citable) accession number: M3WPB0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: October 10, 2018
Last modified: November 7, 2018
This is version 41 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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