UniProtKB - M3WM06 (M3WM06_FELCA)
Protein
Submitted name:
Interferon regulatory factor 6
Gene
IRF6
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- cell cycle arrest Source: Ensembl
- cell development Source: Ensembl
- cranial skeletal system development Source: Ensembl
- immune system process Source: GO_Central
- keratinocyte differentiation Source: Ensembl
- keratinocyte proliferation Source: Ensembl
- limb development Source: Ensembl
- mammary gland epithelial cell differentiation Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Interferon regulatory factor 6Imported |
Gene namesi | Name:IRF6Imported |
Organismi | Felis catus (Cat) (Felis silvestris catus)Imported |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:67828, IRF6 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Other locations
- cell junction Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSFCAG00000015138, Expressed in zone of skin and 11 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 115 | IRF tryptophan pentad repeatInterPro annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 156 | DisorderedSequence analysisAdd BLAST | 36 |
Phylogenomic databases
eggNOGi | ENOG502QRNT, Eukaryota |
GeneTreei | ENSGT00940000157451 |
HOGENOMi | CLU_031544_0_1_1 |
InParanoidi | M3WM06 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
M3WM06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ
60 70 80 90 100
EEENTIFKAW AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT
110 120 130 140 150
KEVPMNPVKI YQVCDIPQPQ GSIINPGSTG SAPWDEKDND VDEEEEEDEL
160 170 180 190 200
DQSQHHVPIQ DTFPFLNING SPMAPASVGN CSVGNCSPEA VWPKTEPLEM
210 220 230 240 250
EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT MTVSNPQGCR
260 270 280 290 300
LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR
310 320 330 340 350
GLILEVSGHA IYAIRLCQCK VYWSGPCAPS PVAPNLIERQ KKVKLFCLET
360 370 380 390 400
FLSDLIAHQK GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR
410 420 430 440 450
MIYEMFSGDF TRSFDSGSVR LQISTPDIKD NIVAQLKQLY RILQTQESWQ
460 470 480
PMQPTPSMQL PTALPAQKTW ECAGPCRTNS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I2U4A6 | A0A2I2U4A6_FELCA | Interferon regulatory factor 6 | IRF6 | 467 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AANG04001043 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSFCAT00000015142; ENSFCAP00000014042; ENSFCAG00000015138 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AANG04001043 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000014042 |
Genome annotation databases
Ensembli | ENSFCAT00000015142; ENSFCAP00000014042; ENSFCAG00000015138 |
Organism-specific databases
VGNCi | VGNC:67828, IRF6 |
Phylogenomic databases
eggNOGi | ENOG502QRNT, Eukaryota |
GeneTreei | ENSGT00940000157451 |
HOGENOMi | CLU_031544_0_1_1 |
InParanoidi | M3WM06 |
Gene expression databases
Bgeei | ENSFCAG00000015138, Expressed in zone of skin and 11 other tissues |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3WM06_FELCA | |
Accessioni | M3WM06Primary (citable) accession number: M3WM06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2013 |
Last sequence update: | February 28, 2018 | |
Last modified: | December 2, 2020 | |
This is version 54 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |