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Entry version 50 (26 Feb 2020)
Sequence version 3 (10 Oct 2018)
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Protein
Submitted name:

Zinc finger BED-type containing 4

Gene

ZBED4

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger BED-type containing 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBED4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome B4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSFCAG00000013152 Expressed in adult mammalian kidney and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000012199

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni166 – 280DisorderedSequence analysisAdd BLAST115
Regioni338 – 409DisorderedSequence analysisAdd BLAST72
Regioni608 – 629DisorderedSequence analysisAdd BLAST22
Regioni1034 – 1053DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 62PolyampholyteSequence analysisAdd BLAST42
Compositional biasi175 – 191Pro-richSequence analysisAdd BLAST17
Compositional biasi344 – 366Pro-richSequence analysisAdd BLAST23
Compositional biasi367 – 381PolarSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRA1 Eukaryota
ENOG41115TD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009123_12_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3WIB4

Database of Orthologous Groups

More...
OrthoDBi
223749at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00614 ZnF_BED, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50808 ZF_BED, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3WIB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENNQEPRPK GDGQFVSAKR NFKIEGEDVR LPNHGLEGVE FKSEQDRKRA
60 70 80 90 100
DGGGERAEAG EAGGGREPPG QRLPADQEEE YGSLFSQYSG TLYDVAMEAV
110 120 130 140 150
TQSLLSGRGA SSRKKSPAWK HFFISPRDST KAICTYCMKE FSRGKNEKDL
160 170 180 190 200
STSCLMRHVR RAHPTVLLPE NGGVPAPPSL SPPPLRLPPA PADTGDPGAV
210 220 230 240 250
LSPAKLAPRL ASKVPSRDDV AEESAVSPEE VPSDASASEK VGREEASGGP
260 270 280 290 300
PPLPTLHCEE TSDSGPERNP PLPKSASGSR RRSAVWKHFY LSPLDNSKAV
310 320 330 340 350
CIHCMNEFSR GKNGKDLGTS CLIRHMWRAH RSIVLQENGG GPGIPPPYAA
360 370 380 390 400
PPTLLPALPP PEGGPGSVSS SPGTLAQESP SASPDRPAED LQGRLNPGDA
410 420 430 440 450
LPEDASALSS DDVGEALLAS SPEKPQGDGL SPGLLESGAV FQQNKKVMKR
460 470 480 490 500
LKSEVWHHFS LAPTDSLKAV CRHCTCVISR GKRGDVGTSC LMRHLYRRHP
510 520 530 540 550
EVVGSQKGLL GAGLADSPYA TLASAEGSSS KLTDLPATVT KHNQVMFPIH
560 570 580 590 600
SKKTSKLWNH FSVCSADPTK VVCLHCGRTI SRGKKPTNLG TSCLLRHLQR
610 620 630 640 650
FHGSALKADA PRAARPSSPG LRGPLGAELS GASSLEDTAE KFYDSHPVAK
660 670 680 690 700
KITSLIAEMI ALDLQPYSFV DNVGFNRLLE YLKPQYSLPS PSYFSRTAIP
710 720 730 740 750
GMYDNVKQIV MSHLKEAESG VVHFTSGIWM SNQTREYLTL TAHWVTFASS
760 770 780 790 800
ARPYREDRHC SALLDVSQVD CDYGGNGIRK QLECWWEAWV TSPGLQVGIT
810 820 830 840 850
VTDNPSIGKT LSEGERASVQ CFSHTVDLVV GEAIKSQRMV QNLLSIARKI
860 870 880 890 900
CERVHRSPKA KEKLAELQKE YALPQRHLIQ DVPSRWNTSF HMLERLIEQK
910 920 930 940 950
RAINEMSVEC NFRELISCDQ WEVMQSVCHA LKPFDAASRE MSAHASTLGQ
960 970 980 990 1000
VIPMIHILNR KIEMLFEETM GIDTMLKSLK EAMVSRLAAT LHDPRYVFAT
1010 1020 1030 1040 1050
LLDPRYKASL FSEEEATQYK QDLIRELEEL NSTSEDAPVS NGCHPGSPSR
1060 1070 1080 1090 1100
DSVGEEDLWS LVAKMTRKGP KEKTKVPEDM VLAYLEEEVL EHSCDPLTYW
1110 1120 1130 1140 1150
SLKRSAWPGL SALAVRFLGC PPSIVPSERL FGTPTENGGF GQSRLTMEHF
1160
EKLIFLKVNL PLIYFQY
Length:1,167
Mass (Da):127,939
Last modified:October 10, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i332E89219CC2F138
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AANG04003413 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSFCAT00000013156; ENSFCAP00000012199; ENSFCAG00000013152

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04003413 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000012199

Genome annotation databases

EnsembliENSFCAT00000013156; ENSFCAP00000012199; ENSFCAG00000013152

Phylogenomic databases

eggNOGiENOG410IRA1 Eukaryota
ENOG41115TD LUCA
GeneTreeiENSGT00940000161365
HOGENOMiCLU_009123_12_2_1
InParanoidiM3WIB4
OrthoDBi223749at2759

Gene expression databases

BgeeiENSFCAG00000013152 Expressed in adult mammalian kidney and 2 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 4 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 4 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3WIB4_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3WIB4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: October 10, 2018
Last modified: February 26, 2020
This is version 50 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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