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Entry version 48 (16 Oct 2019)
Sequence version 3 (10 Oct 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

PCLO

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCLOImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome A2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:80649 PCLO

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSFCAG00000002901 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000002672

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4506 – 4600PDZInterPro annotationAdd BLAST95
Domaini4718 – 4817C2InterPro annotationAdd BLAST100
Domaini5035 – 5126C2InterPro annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 158DisorderedSequence analysisAdd BLAST113
Regioni178 – 605DisorderedSequence analysisAdd BLAST428
Regioni674 – 952DisorderedSequence analysisAdd BLAST279
Regioni969 – 1081DisorderedSequence analysisAdd BLAST113
Regioni1144 – 1415DisorderedSequence analysisAdd BLAST272
Regioni1432 – 1872DisorderedSequence analysisAdd BLAST441
Regioni2173 – 2196DisorderedSequence analysisAdd BLAST24
Regioni2376 – 2443DisorderedSequence analysisAdd BLAST68
Regioni2511 – 2545DisorderedSequence analysisAdd BLAST35
Regioni2559 – 2579DisorderedSequence analysisAdd BLAST21
Regioni2974 – 2993DisorderedSequence analysisAdd BLAST20
Regioni3458 – 3519DisorderedSequence analysisAdd BLAST62
Regioni3569 – 3606DisorderedSequence analysisAdd BLAST38
Regioni3662 – 3755DisorderedSequence analysisAdd BLAST94
Regioni3843 – 3922DisorderedSequence analysisAdd BLAST80
Regioni4288 – 4311DisorderedSequence analysisAdd BLAST24
Regioni4399 – 4421DisorderedSequence analysisAdd BLAST23
Regioni4655 – 4698DisorderedSequence analysisAdd BLAST44
Regioni4839 – 4917DisorderedSequence analysisAdd BLAST79
Regioni4940 – 5003DisorderedSequence analysisAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3219 – 3239Sequence analysisAdd BLAST21
Coiled coili3292 – 3323Sequence analysisAdd BLAST32
Coiled coili3773 – 3810Sequence analysisAdd BLAST38
Coiled coili4919 – 4939Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 139PolarSequence analysisAdd BLAST29
Compositional biasi140 – 154PolyampholyteSequence analysisAdd BLAST15
Compositional biasi186 – 203PolyampholyteSequence analysisAdd BLAST18
Compositional biasi210 – 224Pro-richSequence analysisAdd BLAST15
Compositional biasi234 – 250PolarSequence analysisAdd BLAST17
Compositional biasi257 – 307PolarSequence analysisAdd BLAST51
Compositional biasi353 – 379Pro-richSequence analysisAdd BLAST27
Compositional biasi380 – 404PolarSequence analysisAdd BLAST25
Compositional biasi432 – 454PolarSequence analysisAdd BLAST23
Compositional biasi457 – 575Pro-richSequence analysisAdd BLAST119
Compositional biasi576 – 605PolarSequence analysisAdd BLAST30
Compositional biasi751 – 765Pro-richSequence analysisAdd BLAST15
Compositional biasi787 – 801PolarSequence analysisAdd BLAST15
Compositional biasi869 – 887PolyampholyteSequence analysisAdd BLAST19
Compositional biasi893 – 918Pro-richSequence analysisAdd BLAST26
Compositional biasi919 – 952PolarSequence analysisAdd BLAST34
Compositional biasi969 – 989PolarSequence analysisAdd BLAST21
Compositional biasi990 – 1010Pro-richSequence analysisAdd BLAST21
Compositional biasi1023 – 1056PolyampholyteSequence analysisAdd BLAST34
Compositional biasi1153 – 1169Pro-richSequence analysisAdd BLAST17
Compositional biasi1177 – 1279PolyampholyteSequence analysisAdd BLAST103
Compositional biasi1308 – 1323PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1335 – 1354PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1355 – 1383PolarSequence analysisAdd BLAST29
Compositional biasi1400 – 1415PolarSequence analysisAdd BLAST16
Compositional biasi1432 – 1451PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1452 – 1466PolarSequence analysisAdd BLAST15
Compositional biasi1467 – 1518PolyampholyteSequence analysisAdd BLAST52
Compositional biasi1519 – 1547PolarSequence analysisAdd BLAST29
Compositional biasi1548 – 1568PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1592 – 1606PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1617 – 1657PolyampholyteSequence analysisAdd BLAST41
Compositional biasi1678 – 1692PolarSequence analysisAdd BLAST15
Compositional biasi1721 – 1744PolarSequence analysisAdd BLAST24
Compositional biasi1788 – 1829PolyampholyteSequence analysisAdd BLAST42
Compositional biasi1844 – 1858PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2376 – 2406PolarSequence analysisAdd BLAST31
Compositional biasi2407 – 2441Pro-richSequence analysisAdd BLAST35
Compositional biasi2527 – 2545PolarSequence analysisAdd BLAST19
Compositional biasi3458 – 3483PolyampholyteSequence analysisAdd BLAST26
Compositional biasi3492 – 3516PolyampholyteSequence analysisAdd BLAST25
Compositional biasi3576 – 3594PolarSequence analysisAdd BLAST19
Compositional biasi3691 – 3755PolarSequence analysisAdd BLAST65
Compositional biasi3865 – 3922PolarSequence analysisAdd BLAST58
Compositional biasi4290 – 4311PolarSequence analysisAdd BLAST22
Compositional biasi4655 – 4687PolarSequence analysisAdd BLAST33
Compositional biasi4845 – 4861PolarSequence analysisAdd BLAST17
Compositional biasi4880 – 4917PolarSequence analysisAdd BLAST38
Compositional biasi4940 – 4980PolarSequence analysisAdd BLAST41

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISKT Eukaryota
ENOG4111PJ9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00620000087961

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3VZD0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15774 FYVE1_PCLO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR042720 PCLO_FYVE1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030629 Piccolo
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR14113:SF6 PTHR14113:SF6, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
PF05715 zf-piccolo, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M3VZD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNEASLEGE GLPEGLAAAA AAAAGGGAGG AGSSLHTVIP AGMEADLSQL
60 70 80 90 100
SEEERRQIAA VMSRAQGLPK GSVPPAAAEP SSMHRKQELD SSHPPKQSGK
110 120 130 140 150
PPDPGRSAPP GLSKSRTTDT LRSEQKLPGR SPSTISLKES KSRTDLKEEH
160 170 180 190 200
KSSMMPGFLS EVNPLSAVSS VVNKFNPFDL ISDTDSSQEE TAKKQKMAQK
210 220 230 240 250
EQGKPEGITK PPPQQSPKPV PKQQGPARVP LQQDGSPRSV SSQQPEKIKL
260 270 280 290 300
QPSGTGKPIE GLTQAPQTDQ AQLPLQRDAT RPQTKQSDTL RGESVKPSLQ
310 320 330 340 350
SPSKPPIQQG GPGKPPAQQP GPEKLATAQP GPAKPLAQQT GPAKALAQQP
360 370 380 390 400
GTAKPPAQPP GTTKPTAQQP GPKSPAQPVG PAKPQTQQAG SDKLPSQQQG
410 420 430 440 450
PAKPPAQQPG TPKSPAHQPG SQSPAQPPGP AKTPSQQVGA TKSLGQQPGT
460 470 480 490 500
GKTPAQQPGP AKPPPQQPGP AKPPPQQPGP AKPPPQQPGP AKPPPQQPGP
510 520 530 540 550
AKPPPQQPGP AKPPPQQPGP AKPPPQQPGP AKPPSQQPGP AKPPPQQPGP
560 570 580 590 600
AKPPSQQPSP AKPPPQQPGP AKPSAQPSTK PVSQTEAGKP PQPSTAPSAA
610 620 630 640 650
QTPGQGLPKT ICPLCNTTEL LLHVPEKANF NTCTECQTTV CSLCGFNPNP
660 670 680 690 700
HLTEIKEWLC LNCQMKRALG GDLAPVPSSP QPKPKIAPVG PASAVSKPSP
710 720 730 740 750
QPQHTSPKKD TVPKQEISKA PESKRPPPLV KQPTIHGSPP LAARQPPAAA
760 770 780 790 800
ESSPKPAPPK EPLVPSEQAE VPVADDKPKQ PKTGKPAADV ASSSSVAAQP
810 820 830 840 850
DIPSPKVQLE DQEIITPPLK IDAAKPSQSF PPTGEKVTPF DSKVIPRPAS
860 870 880 890 900
DSKIISHPGP SPEGKGQKQA DPVQKREEPK KAQTKMSPKP DAKPMPKGSP
910 920 930 940 950
PPAGPRPPTG PTAPTAQQPP KPQEQSRRFS LNLGSITDAP KSQPTTPQET
960 970 980 990 1000
VTGKLFGFGA SIFSQASNLI STAGQPGSQS QSALGAPTKQ GPPPSQPPPS
1010 1020 1030 1040 1050
QGPPKSTGQV PPAPAKVVPV KKEAKAPVVE KLEPKSEPVP TVKRTETEKK
1060 1070 1080 1090 1100
PLPVKDSKPL TAEPQKAVLP PKLEKTPKPE SACPLCKTEL NIGSKDPPNF
1110 1120 1130 1140 1150
NTCTECKNQV CNLCGFNPMP HLTEIQEWLC LNCQTQRAIS GQLGDMGKMP
1160 1170 1180 1190 1200
PTPSAPKASP MPVPPEQPSQ KTAMPTQVKV KKKEQEVKTE AEQIIPEKVK
1210 1220 1230 1240 1250
EIPSVEKIVP KGTTDHKQES KLEKTSAPED KKPLPEEEKP PLEEKKPPTE
1260 1270 1280 1290 1300
DKKLPPGTKT ALEEEQKQDL AKTQVPTAEE KPEGRVTPQV VQEKLPQTKM
1310 1320 1330 1340 1350
EDKPSGPPPS LSKEDDEVPQ KIKDQPQAAR PAKPDQVEPG KEKTEKEDDK
1360 1370 1380 1390 1400
SDTSSSQQPK SPQGLSDTGY SSDGISSSLG EIPSLIPSDE KDLLKGLKKD
1410 1420 1430 1440 1450
SFSQESSPSS PSDLAKLEST VLSILEAQAS TLVEEKSEKK TQPHEVSSEQ
1460 1470 1480 1490 1500
PKDPQKTQSL SETVETTISE EELKKSPEEK DTLKKDSQQD IPSRKDHEEK
1510 1520 1530 1540 1550
SEFVDDTATR RQLYDSVEDS SESENSPVPQ RKRRTSVGSS SSDEYKQEDS
1560 1570 1580 1590 1600
QGSGEEEDFI RKQIIEMSAD EDASASEDDE FIRSQLKEIS SSIESQKKED
1610 1620 1630 1640 1650
MKGKGKATAG KHRRLTRKSS ASFDDDAGRR HSWHDEDDET FDESPELKYR
1660 1670 1680 1690 1700
ETKSQESEEL VVAGGGGLRR FKTIELNSTI ADKYSADSSQ KKTALYFDEE
1710 1720 1730 1740 1750
PELEMESLTD SPEDRSRGEG SSSLHASSFT PGTSPTSVSS LDEDSDSSPS
1760 1770 1780 1790 1800
HKKGESKQQR KARHRSHGPL LPTIEDSSEE EELREEEELL KEQEKQRELE
1810 1820 1830 1840 1850
QQQRKTSSKK SKKDKDELRA QRRRERPKTP PSNLSPIEDA SPTEELRQAA
1860 1870 1880 1890 1900
EMEELHRSSC SEYSPSIESD PEGFEISPEK IIEVQKVYKL PTAVSLYSPT
1910 1920 1930 1940 1950
DEQSIMQKEG GQKSLKSAEE MYEEMMHKTH KYKPFPAVPE RDEMFEKEPL
1960 1970 1980 1990 2000
YGGMLIEDYI YESLVEDTYN GSVDGSLLTR QEDENGFMQQ RGKEQKIRLP
2010 2020 2030 2040 2050
EQIYEDPMQK ITDLQKEFYE LESLHSIVPQ EDIVSSSFII PESHEIVDLG
2060 2070 2080 2090 2100
SMVTSTSEEK KLLDADAAYE ELMKRQQMQL TPGSSPTQPP ITDDMIESTV
2110 2120 2130 2140 2150
DFDRVPDASL TSSVLSGASL TDSTSSATLS IPDVKITQHF STEEIEDEYV
2160 2170 2180 2190 2200
TDYTREIQEI IAHESLILTY SEPSESATSV PPSDTPSLTS SVSSVCTTDS
2210 2220 2230 2240 2250
SSPVTTLDSI TTVYMEPVDV VTKFEDSEGI SSSTYFPGSI IDYPEEISVS
2260 2270 2280 2290 2300
LDRATTPDGR TGADHIVISL SDVEPPILES IGTKPEGLIA DTVSTDLPVS
2310 2320 2330 2340 2350
AKDAVKKAKK DTGNGIILEV LEAYRDKKEK TEVELTKMSF SETVFDQPPS
2360 2370 2380 2390 2400
SAVALPVGER VSATCFISGQ VFDQTKPASP LPSGSPSVTS LPTKTRPFFR
2410 2420 2430 2440 2450
SSSLDTSAQP PPPPPPPPPP PPPPPPPPPP PLPPPTSPKP IIHPTKKLTI
2460 2470 2480 2490 2500
TAPETVTTTA KPLVDGVTTV EATAIPRSNG LPVTKICTTA PPPVPPKPSS
2510 2520 2530 2540 2550
IPSGLVFTHR PEPSKPPIAP KPAVPQLPVT TQKSTDTHPK PTGLSLASNM
2560 2570 2580 2590 2600
TLNLVTSADY KLPSPTSPAS PHSNKSSPRF SKSLMETYVV ITLPSEPGTP
2610 2620 2630 2640 2650
TDSSTSQAVT SWPLGSPPKD LISIEPVFSV VPPMTTAGMP SSSEQSLYMS
2660 2670 2680 2690 2700
GALETFSAVP VTTLSSFQAA PTSVTQFFTT EVSKAEASAA RSALTSVGLS
2710 2720 2730 2740 2750
SVSISIPPEP LALDNLHLEK RQHKENGKLP LVGDAIDLRT VPKVEVKVTE
2760 2770 2780 2790 2800
KCMDLSASTM DMKRQTTTHE VYGRQISAVQ PSIINLSATS SAVTPMPLVT
2810 2820 2830 2840 2850
ETVTVVTCAA SSGYTMGPES LVGIEHATPA PLQLTTSKHA EPPPYRIPSG
2860 2870 2880 2890 2900
QAFPAVREDA PINLSLGTSA HPVTSAVTKP VTAPPVGVTN GWTDSVTRQG
2910 2920 2930 2940 2950
MADGEVVDLS TTKSHRTVVT MDESTSGVVT KIVEDDEKPV DLTAGRRAVC
2960 2970 2980 2990 3000
CDMVYKLPFG RSCTAQQPAT TLPEDRFGYR DDHYQYDRSG PSGYRGIGGM
3010 3020 3030 3040 3050
KPSMSDTNLA EAGHFFYKSK NAFDYSGGTD TAVDLTSGRI TAGEVMDYSS
3060 3070 3080 3090 3100
KTTGPYPETR QVISEVGIST PQYSTARMTP PPGSQYGVGS VLRSSNGVVY
3110 3120 3130 3140 3150
SSVATPIPST FAITTQPGSI FSTTVRDLSG VHTADAVTSL SALHQSQPMP
3160 3170 3180 3190 3200
RSYFLTTGAS ETDIAATGID INASLQTITV ETLTAETIDS VPTLTTASDV
3210 3220 3230 3240 3250
FSEVVGDESA ILIVPEEGKQ QQQLDLEREL LELEKIKQQR FAEELEWERQ
3260 3270 3280 3290 3300
EIQRFREQEK IMVQKKLEEL QSMKQHLLYQ QEEERQAQFM MRQETLAQQQ
3310 3320 3330 3340 3350
LQLEQIQQLQ QQLHQQLEEQ KIRQIYQYNY DPSGTASPQT TTEQAILEGQ
3360 3370 3380 3390 3400
YAAPEGGQFW ATEDATTTAS AVVAIEIPQS QGWYTVQSDG VTQYIAPPGI
3410 3420 3430 3440 3450
LSTVSEIPLT DVVVKDEKPP KKRSAAAKVR GQYDELGEHM ADDPRCFKKI
3460 3470 3480 3490 3500
VDSGVQTDDE DAADRSYVSR RRRTKKSVDT SVQTDDEDQD EWDVPARARR
3510 3520 3530 3540 3550
KARVGKYGDS TAEADKTKPL SKVSSIAVQT VAEISVQTEP VGTIRTPSVR
3560 3570 3580 3590 3600
ARVDAKVEII KHISAPEKTY KGGSLGCQTE ADSDTQSPQY LSATSPPKDK
3610 3620 3630 3640 3650
KRPTPLEIGY SSHLRADSTL QLAPSPPKSP KVLYSPISPL SPGKALESAF
3660 3670 3680 3690 3700
VPYEKPLPDD ISPQKVLHPD MAKVPPASPK TAKMMQRSMS DPKPLSPTAD
3710 3720 3730 3740 3750
ESSRAPFQYT EGYTTKGSQT MTPSGSQKKV KRTLPNPPPE ETSTGTQSTY
3760 3770 3780 3790 3800
STMGTVSRRR ICRTNTMARA KILQDIDREL DLVERESAKL RKKQAELDEE
3810 3820 3830 3840 3850
EKEIDAKLRY LEMGINRRKE ALLKEREKRE RAYLQGVAED RDYMSDSEVS
3860 3870 3880 3890 3900
STRPTRIESQ HGIERPRTAP QTEFSQFIPP QTQTESQLVP PTSPYTQYQY
3910 3920 3930 3940 3950
SSPALPTQAP TPYTQQSHFQ QQTLYHQQVS PYQTQPTFQA VATMSFTPQA
3960 3970 3980 3990 4000
QPTPTPQPSY QLPSQMMVIQ QKPRQTTLYL EPKITSNYEV IRNQPLMIAP
4010 4020 4030 4040 4050
VSTDNTYAVS HLGSKYNSLD LRIGLEERSS MASSPISSIS ADSFYADIDH
4060 4070 4080 4090 4100
HTPRNYVLID DIGEITKGTA ALSTAFSLHE KDLSKTDRLL RSTETRRSQE
4110 4120 4130 4140 4150
VTDFLAPLQT SSRLHSYVKA EEDPMEDPYE LKLLKHQIKQ EFRRGAESLD
4160 4170 4180 4190 4200
HLAGLSHYYH ADTGYRHFPK SEKYSISRLT LEKQAAKQLP AAILYQKQSK
4210 4220 4230 4240 4250
HKKSLIDPKM SKFSPIQESR DLEPDYTSYM TSSTSSIGGI SSRARLLQDD
4260 4270 4280 4290 4300
ITFGLRKNIT DQQKFMGSSL GTGLGTLGNT LRSALQDEAD KPYSSGSRSR
4310 4320 4330 4340 4350
PSSRPSSVYG LDLSIKRDSS SSSLRLKAQE AEALDVSFSH ASPSGRTKPT
4360 4370 4380 4390 4400
SLPISQSRGR IPIVAQNSEE ESPLSPVGQP MGMARAAAGP LPPISADTRD
4410 4420 4430 4440 4450
QFGSSHSLPE VQQHMREESR TRGYDRDIAF IMDDFQHAMS DSEAYHLRRE
4460 4470 4480 4490 4500
ETDWFDKPRE SRLENGHGLD RKLPERLVHS RPLSQHQEQI IQMNGKTVHY
4510 4520 4530 4540 4550
IFPHARIKIT RDSKDHTVSG NGLGIRIVGG KEIPGHNGEI GAYIAKILPG
4560 4570 4580 4590 4600
GSAEQTGKLM EGMQVLEWNG IPLTSKTYEE VQSIIGQQSG EAEICVRLDL
4610 4620 4630 4640 4650
NMLSDSENPQ HLELHEPPKA VEKAKSPGVD PKQLAAELQK VSLQQSPLVL
4660 4670 4680 4690 4700
SSVVEKGSHV HSGPTSAGSS SVPSPGQPGS PSVSKKKHGS SKPTDAAKVV
4710 4720 4730 4740 4750
SHPITGEIQL QINYDLGNLI IHILQARNLV PRDNNGYSDP FVKVYLLPGR
4760 4770 4780 4790 4800
GQVMVVQNAS AEYKRRTKYV QKSLNPEWNQ TVIYKSISME QLKKKTLEVT
4810 4820 4830 4840 4850
VWDYDRFSSN DFLGEVLIDL SSTSHLDNTP RWYSLKEQTE SLDHGKSHSS
4860 4870 4880 4890 4900
QGSQQPPKPS VIKSRSHGIF PDPSKDMQVP TIEKSHSSPG SSKSSSEGHL
4910 4920 4930 4940 4950
RSHGPSRSQS KTSVTQTHLE DAGAAIAAAE AAVQQLRLQP TKPTNHRPAE
4960 4970 4980 4990 5000
SSVSTGSSGS SFGSGYSVDS EGSSGTAGET NLFPIPRIGK MGQNGQEPVK
5010 5020 5030 5040 5050
QPGVGVGLTD AEVKTQVMGE IKIALKKEMK TDGEQLIVEI LQCRNITYKF
5060 5070 5080 5090 5100
KSPDHLPDLY VKIYVMNIST QKKVIKKKTR VCRHDREPSF NETFRFSLSP
5110 5120 5130 5140 5150
AGHSLQILLF SNGGKFMKKT LIGEACIWLD KVDLRKRIVN WHKLLVSPTQ

TH
Length:5,152
Mass (Da):559,403
Last modified:October 10, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0B169E0CD729DC9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A337SB45A0A337SB45_FELCA
Uncharacterized protein
PCLO
5,177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A337SK78A0A337SK78_FELCA
Uncharacterized protein
PCLO
5,168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AANG04003224 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSFCAT00000002902; ENSFCAP00000002672; ENSFCAG00000002901

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04003224 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000002672

Genome annotation databases

EnsembliENSFCAT00000002902; ENSFCAP00000002672; ENSFCAG00000002901

Organism-specific databases

VGNCiVGNC:80649 PCLO

Phylogenomic databases

eggNOGiENOG410ISKT Eukaryota
ENOG4111PJ9 LUCA
GeneTreeiENSGT00620000087961
InParanoidiM3VZD0

Gene expression databases

BgeeiENSFCAG00000002901 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd15774 FYVE1_PCLO, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR042720 PCLO_FYVE1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030629 Piccolo
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR14113:SF6 PTHR14113:SF6, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
PF05715 zf-piccolo, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3VZD0_FELCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3VZD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: October 10, 2018
Last modified: October 16, 2019
This is version 48 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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