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Protein

DNA polymerase alpha subunit B

Gene

POLA2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase alpha subunit BUniRule annotation
Gene namesi
Name:POLA2Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome D1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSFCAG00000001440 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000001337

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase alpha subunit B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1625 Eukaryota
COG5214 LUCA
GeneTreeiENSGT00390000016784
InParanoidiM3VWM7
KOiK02321
OMAiGDREHSS
OrthoDBiEOG091G0C6I

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit

Sequencei

Sequence statusi: Complete.

M3VWM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSAQRLVE ELQIFDVDCD EALAEKLVEL CILYGQNEEK MATELIAFCT
60 70 80 90 100
STGNVRLTAE TLSSFEHECL SKRLPKASHR ASGDGGHAGA RDIVSIQELI
110 120 130 140 150
EVEEEEETLL NSYTTPSKGS QKRAITTPET PLTKRTVSTR SPHQLLSPSS
160 170 180 190 200
FSPSAAPSQK YNARSNRGEV VTSFGSAQGG SWSGRGGAGN ISLKVLGCPE
210 220 230 240 250
ALTGSYKSMF QKLPDIREVL TCKIEELGSE LKEHYQIEAF TSVLVPAQEP
260 270 280 290 300
VTLLGQIGCD TNGKLNSKSV ILEGDREHSS GAQIPVDLSE LKEYSLFPGQ
310 320 330 340 350
VVILEGINTT GAKLIATKLY EGVPLPFYQP PKEDEDFEQN MVLVACGPYT
360 370 380 390 400
TSDSITYDPL LDLIAIINRD RPDVCILLGP FLDAKHEQVE NCLLTSPFED
410 420 430 440 450
VFKQCLRTII EGTRSSGSHL VFVPSLRDVH HESVYPQPPF SYSDLPREDI
460 470 480 490 500
KRVRFVSEPC SLSVNGVVFG LTSTDLLFHM GAEEISSSSG TSDRLSRILK
510 520 530 540 550
HILTQRSYYP LYPPQEDMAI DYENFYTYAQ LPVTPDVFII PSELKYFVKD
560 570 580 590
VLGCVCVNPG RLTKGQVGGT FGRLLLRRQR AEDGEGRRSP CAAAQVVRI
Length:599
Mass (Da):65,901
Last modified:February 28, 2018 - v2
Checksum:i658485BBE52A490F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04000779 Genomic DNA No translation available.
RefSeqiXP_003993639.1, XM_003993590.4

Genome annotation databases

EnsembliENSFCAT00000001440; ENSFCAP00000001337; ENSFCAG00000001440
GeneIDi101084827
KEGGifca:101084827

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04000779 Genomic DNA No translation available.
RefSeqiXP_003993639.1, XM_003993590.4

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000001337

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000001440; ENSFCAP00000001337; ENSFCAG00000001440
GeneIDi101084827
KEGGifca:101084827

Organism-specific databases

CTDi23649

Phylogenomic databases

eggNOGiKOG1625 Eukaryota
COG5214 LUCA
GeneTreeiENSGT00390000016784
InParanoidiM3VWM7
KOiK02321
OMAiGDREHSS
OrthoDBiEOG091G0C6I

Gene expression databases

BgeeiENSFCAG00000001440 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM3VWM7_FELCA
AccessioniPrimary (citable) accession number: M3VWM7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: February 28, 2018
Last modified: October 10, 2018
This is version 36 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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