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UniProtKB - M3VVL1 (M3VVL1_FELCA)

Entry version 51 (12 Aug 2020)
Sequence version 4 (11 Dec 2019)
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Protein
Submitted name:

Nuclear factor of activated T cells 1

Gene

NFATC1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear factor of activated T cells 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFATC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome D3

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:68469, NFATC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSFCAG00000000884, Expressed in tip of external ear and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9685.ENSFCAP00000000822

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini554 – 736RHDInterPro annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 104DisorderedSequence analysisAdd BLAST104
Regioni193 – 218DisorderedSequence analysisAdd BLAST26
Regioni346 – 444DisorderedSequence analysisAdd BLAST99
Regioni806 – 964DisorderedSequence analysisAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 43PolyampholyteSequence analysisAdd BLAST23
Compositional biasi74 – 94Pro-richSequence analysisAdd BLAST21
Compositional biasi380 – 410PolarSequence analysisAdd BLAST31
Compositional biasi421 – 444PolarSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTX8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157616

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010185_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		M3VVL1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR008366, NFAT
IPR015647, NFAT1
IPR008967, p53-like_TF_DNA-bd
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR12533, PTHR12533, 1 hit
PTHR12533:SF5, PTHR12533:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01789, NUCFACTORATC

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

M3VVL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQGGGAGA AGPAGRRGRC FPALKRQEAE RGPASERHSE DSELAGTVTA 
        60         70         80         90        100
PGRAAGRGHR GAGAHRRAPA TPPPRHAARA PGPRLGPPRA HTPPNDICPG 
       110        120        130        140        150
RAALSRGRGP CLPGRPGRGG GAERLPLLLP LLLLPAAAAA AAAAWMPSTS 
       160        170        180        190        200
FPVPSKFPLG PPAAVCGSGE TLGPAPPSGG TMKSAEEEHY SYAPPSIGTA 
       210        220        230        240        250
LPPGPAHPSL PALCHDLQSA APGMPGAAAG QPPGYGGAVD GGPSGYLLSS 
       260        270        280        290        300
SHIRPNGAPA LESPRIEITS YMGLHHGNNQ FFHDVEVGDV IPSSKRPPST 
       310        320        330        340        350
ATLNLPNLEA YRDPSCLSPA SSLSSRSCNS EASSYESNFS YPYASPQTSP 
       360        370        380        390        400
WQSPCVSPKT TDPEEGFPRG LGACGLLGSP RHSPSTSPRT SVTEESWLGA 
       410        420        430        440        450
RTSRPSSPCN KRKYGLNGRQ LSCSPHHSPT PSPRSSPRVS VTDDTWLGNS 
       460        470        480        490        500
TQYTSSAIVA AINALSTDST LELGDGVPVK ARKTALDRCP SVALKVEPAG 
       510        520        530        540        550
EDLGATPPTS EFLPEEVPPF QHIRKGAFCD QYLSVPQHPY QWARPRSPTS 
       560        570        580        590        600
YASPSLPALD WQVPSRSGPY ELRIEVQPKP HHRAHYETEG SRGAVKASAG 
       610        620        630        640        650
GHPSVQLHGY LENEPLTLQL FIGTADDRLL RPHAFYQVHR ITGKTVSTTS 
       660        670        680        690        700
HEAILSNTKV LEIPLLPENN MRAIVDCAGI LKLRNSDIEL RKGETDIGRK 
       710        720        730        740        750
NTRVRLVFRV HIPQPNGRTL SLQVASNPIE CSQRSAQELP LVEKQSAASC 
       760        770        780        790        800
PVLGGKKMVL SGHNFLQDSK VIFVEKAPEF VGGRDTAFPQ SENNEPRPSQ 
       810        820        830        840        850
FLRLQREEEE EPVSALDLPS CERSNHKNRA RRRPRACPDL WARGPGPEPA 
       860        870        880        890        900
PAAALQPAAR GATRPGLLPG GRLPALSAEK HRGVAATRHR PGAPRPIFRC 
       910        920        930        940        950
LRQGHGQPGP RPPWTSAAGR RGARRSGDAE ACGRAPRAPP AAAPRPAATT 
       960 
VNEIIRNDLS STNI
Length:964
Mass (Da):102,054
Last modified:December 11, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14665D8818C9FB5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2UJJ5A0A2I2UJJ5_FELCA
Nuclear factor of activated T cells...
NFATC1
890Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5XKD9A0A5F5XKD9_FELCA
Nuclear factor of activated T cells...
NFATC1
1,085Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5XIM1A0A5F5XIM1_FELCA
Nuclear factor of activated T cells...
NFATC1
927Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5XM89A0A5F5XM89_FELCA
Nuclear factor of activated T cells...
NFATC1
855Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5XXA4A0A5F5XXA4_FELCA
Nuclear factor of activated T cells...
NFATC1
851Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5XV56A0A5F5XV56_FELCA
Nuclear factor of activated T cells...
NFATC1
683Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AANG04000315 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSFCAT00000000884; ENSFCAP00000000822; ENSFCAG00000000884

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG04000315 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000822

Genome annotation databases

EnsembliENSFCAT00000000884; ENSFCAP00000000822; ENSFCAG00000000884

Organism-specific databases

VGNCiVGNC:68469, NFATC1

Phylogenomic databases

eggNOGiENOG502QTX8, Eukaryota
GeneTreeiENSGT00940000157616
HOGENOMiCLU_010185_1_0_1
InParanoidiM3VVL1

Gene expression databases

BgeeiENSFCAG00000000884, Expressed in tip of external ear and 11 other tissues

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR008366, NFAT
IPR015647, NFAT1
IPR008967, p53-like_TF_DNA-bd
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR12533, PTHR12533, 1 hit
PTHR12533:SF5, PTHR12533:SF5, 1 hit
PfamiView protein in Pfam
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR01789, NUCFACTORATC
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3VVL1_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3VVL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: December 11, 2019
Last modified: August 12, 2020
This is version 51 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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