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Entry version 39 (10 Feb 2021)
Sequence version 1 (01 May 2013)
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Protein

Fatty acid synthase beta subunit hexB

Gene

hexB

Organism
Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fatty acid synthase beta subunit; part of the fragmented gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963, PubMed:22069571, PubMed:23207690, PubMed:23448391).

The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits hexA and hexB, as well as the polyketide synthase pksA (PubMed:16649078, PubMed:23207690).

PksA combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR (By similarity).

The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase hexA/hexB (By similarity).

The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase nor1, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin (PubMed:23207690).

The cytochrome P450 monooxygenase avnA then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN) (PubMed:23207690).

The next step is performed by adhA that transforms HAVN to averufin (AVF) (PubMed:23207690).

Averufin might then be converted to hydroxyversicolorone by cypX and avfA (PubMed:23207690).

Hydroxyversicolorone is further converted versiconal hemiacetal acetate (VHA) by moxY (PubMed:23207690).

VHA is then the substrate for the versiconal hemiacetal acetate esterase est1 to yield versiconal (VAL) (PubMed:23207690).

Versicolorin B synthase vbsA then converts VAL to versicolorin B (VERB) by closing the bisfuran ring (PubMed:16649078, PubMed:23207690).

Then, the activity of the versicolorin B desaturase verB leads to versicolorin A (VERA) (PubMed:23207690).

DotB, a predicted chloroperoxidase, may perform epoxidation of the A-ring of VERA (PubMed:23207690).

Alternatively, a cytochrome P450, such as cypX or avnA could catalyze this step (PubMed:23207690).

It is also possible that another, uncharacterized, cytochrome P450 enzyme is responsible for this step (PubMed:23207690).

Opening of the epoxide could potentially be achieved by the epoxide hydrolase epoA (PubMed:23207690).

However, epoA seems not to be required for DOTH biosynthesis, but other epoxide hydrolases may have the ability to complement this hydrolysis (PubMed:23207690).

Alternatively, opening of the epoxide ring could be achieved non-enzymatically (PubMed:23207690).

The next step is the deoxygenation of ring A to yield the 5,8-dihydroxyanthraquinone which is most likely catalyzed by the NADPH dehydrogenase encoded by ver1 (PubMed:23207690).

The last stages of DOTH biosynthesis are proposed to involve hydroxylation of the bisfuran (PubMed:23207690).

OrdB and norB might have oxidative roles here (PubMed:23207690).

An alternative possibility is that cytochrome P450 monoogenases such as avnA and cypX might perform these steps in addition to previously proposed steps (PubMed:23207690).

1 PublicationBy similarity3 Publications2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase
LigandNAD, NADP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fatty acid synthase beta subunit hexB1 Publication (EC:2.3.1.861 Publication)
Alternative name(s):
S-acyl fatty acid synthase thioesterase1 Publication (EC:3.1.2.141 Publication)
Including the following 4 domains:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase1 Publication (EC:4.2.1.591 Publication)
Enoyl-[acyl-carrier-protein] reductase [NADH]1 Publication (EC:1.3.1.91 Publication)
[Acyl-carrier-protein] acetyltransferase1 Publication (EC:2.3.1.381 Publication)
[Acyl-carrier-protein] malonyltransferase1 Publication (EC:2.3.1.391 Publication)
Alternative name(s):
Dothistromin biosynthesis protein hexB1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hexB1 Publication
ORF Names:DOTSEDRAFT_181128
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri675120 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeMycosphaerellalesMycosphaerellaceaeDothistroma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000016933 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004434571 – 1904Fatty acid synthase beta subunit hexBAdd BLAST1904

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by the dothistromin-specific transcription factors aflR and aflJ (PubMed:23207690, PubMed:25986547).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

[Alpha6beta6] hexamers of two multifunctional subunits (alpha and beta).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
64363.EME39032

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M2XHU6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1399 – 1512MaoC-likeSequence analysisAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 395Acetyltransferase (AT) domainSequence analysisAdd BLAST372
Regioni447 – 691Enoyl reductase (ER) domainSequence analysisAdd BLAST245
Regioni1001 – 1491Dehydratase (DH) domainSequence analysisAdd BLAST491
Regioni1530 – 1893Malonyl/palmitoyl transferase (MT/PT) domainSequence analysisAdd BLAST364

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQJX, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000114_5_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAGHFRA

Database of Orthologous Groups

More...
OrthoDBi
8490at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit
3.40.366.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013785, Aldolase_TIM
IPR016452, Fas1/AflB-like
IPR013565, Fas1/AflB-like_central
IPR040883, FAS_meander
IPR003965, Fatty_acid_synthase
IPR029069, HotDog_dom_sf
IPR039569, MaoC-like_dehydrat_N
IPR002539, MaoC-like_dom
IPR032088, SAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF08354, DUF1729, 1 hit
PF17951, FAS_meander, 1 hit
PF13452, MaoC_dehydrat_N, 1 hit
PF01575, MaoC_dehydratas, 1 hit
PF16073, SAT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005562, FAS_yeast_beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01483, FASYNTHASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52151, SSF52151, 2 hits
SSF54637, SSF54637, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M2XHU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSQHQSQHN SALIQAARDG EATLSVAFGG QGPSNLNCFN DLLELNKTYG
60 70 80 90 100
STLRPLIHTA DATLSELASL PHRSGFHEDE GFETLDWLQD PKQAPSREYL
110 120 130 140 150
ALSPMSFPIN TLLSLCNYCV TLRALRLDPG QFRSSLHNVV GHSQGIFAAA
160 170 180 190 200
AIAKADSWES FLEAAEIALK ISFWVGLESH TAAPPSHISA AAVQDCVEHG
210 220 230 240 250
EGQPSSMLGI TGLNRAQVEM LVERVNKSLS DDDRHVCLAL ANSRDKYTIA
260 270 280 290 300
GPPHSLRAVC VQIREIRAAD GVDQSRILFN KRKQEVDALF LPISAPYHSQ
310 320 330 340 350
YLKQVSNNVL DALDVDLVGS ELGIPLLHTQ SGQNLQDWKS KSIIKAIVCA
360 370 380 390 400
VTTDMVEWPD VCQRLGSSYI LGFGPGNIGN LIHESTEGTG VRVIQMNDRS
410 420 430 440 450
PGSRGIGARA ELFSEEMPPQ ALDWKQTFGP RLVLDHRGDV QIQTRMTQLL
460 470 480 490 500
NAPPVMVAGM TPTTVTWDFV SCVMQAGYHV ELAGGGYSSE ARFEEALRRL
510 520 530 540 550
AASIPIYRGI TCNLLYANPQ TIAWQVAVLR RLIKEGISIE GVTIGAGVPS
560 570 580 590 600
PDVIKEYIAI GLKHISFKPG SIAAIDEVIE IAQAHPQFPI GLQWTGGRAG
610 620 630 640 650
GHHSHEDLHL PILKTYARIR RCSNIVLIAG SGFGGGSDTY PYISGDWSKS
660 670 680 690 700
LSYPPMPFDG ILLGSRVMVA KEAHTSPQAK QLIVQTEGVG DNDWHTSFET
710 720 730 740 750
PTGGVITITS EHGQPIHMLA TRGVMLWKEF DKRIFSIKDA AKRLSYIRAH
760 770 780 790 800
REEIITRLNK DYQKPWFGVN GDGQNVDLDR MTYREVLGRM CQLMSRGDNG
810 820 830 840 850
WTDPSWLAMV KDFVEIAGER FGCQVDAHAT KAPEVRTAFE ATLGGSVDET
860 870 880 890 900
LYPEDVALVL ELLRRRGRKP PPFVPALDEN FETWCKKDSL WQSEDVDSLV
910 920 930 940 950
GKDVQRACII QGPVAVRHST IHDEPVQDIL DNICNFHIES LLQSGETPGV
960 970 980 990 1000
ARKQDLGRPN SIKKSVPGVQ ITTEKTTIRY QVHKTDKLPP EMDTLIEHIV
1010 1020 1030 1040 1050
GPAADCWTHH CLKDEWVFRD QARLRNPIRA AFLRQIQPGE VIEVRLSRDG
1060 1070 1080 1090 1100
NTQAIALKTA LFGKSSLQTV LRIASTDGKS IKVALTPPSF LSDKPLGLQF
1110 1120 1130 1140 1150
AYQLSRKSRG SKLVEVTPNR LDAIKGFYAQ LWVDSNQDVK EAGLNSEFWG
1160 1170 1180 1190 1200
EPTTLLAQDV QNYTAVVSRS TSPQLQAWNP TGSVPVDYCI VLAWTALTKP
1210 1220 1230 1240 1250
LTIPALQCDL LNLLHRSVNF KYAANARPLR LGDVTQTVSR ITSLTIQPTG
1260 1270 1280 1290 1300
KLVEVSAELR RNDETVVTIT TEFFIVGQFE DYETQFKSFE EPLFEVRVHS
1310 1320 1330 1340 1350
VTRQALLQSR KWLVLDDPSM DLAGLTLAFK LNTHTTFDHE GKVGALQVTG
1360 1370 1380 1390 1400
SVSRVESTGF DTRIGKVYFK KDSCNGNPVV DFLNRHGYPR VTRQPLENPG
1410 1420 1430 1440 1450
WNEGSTVLMK APAKSNQYAM ASKDTNPLHV CGVFARYAGL PDTVVHGMHT
1460 1470 1480 1490 1500
SAIVRRAVEW AVGDSDRSRF KKWQVSFEGM VRPNDRLKIQ LQHTAMEHGR
1510 1520 1530 1540 1550
MIMKVQAFND ETGDKVIEAE AEVEQPRTGY VFCGQGSQEK GMGMSLYNAR
1560 1570 1580 1590 1600
PEAKALWDRG DQFLREQYGF SLLSLVRENP TTLTINFGGR RGKRIRDNYL
1610 1620 1630 1640 1650
AMTKKTSLKA DAKDVCIVQG LTPTSTSHTF SETKGLLFST QFSQPAIALM
1660 1670 1680 1690 1700
EMVEHEHLFA KGVVQPSALF AGHSLGEYAA LGACTTFMPF ESLLTLIFYR
1710 1720 1730 1740 1750
GLKMQNALER DANGRTDYSM MAADPSRVGK AGFDERAFQC LVELVNEETG
1760 1770 1780 1790 1800
LLMEIVNHNV RSQQYVCAGH FRALWILGKV CDDLAKHPKI HLLSMQDLKD
1810 1820 1830 1840 1850
MVTTHVPAAG KLTNDIVLTR GKATIPLNGI DIPFHSTMLR GEIEHFRRYL
1860 1870 1880 1890 1900
LTKVNVPDIK PNELVGKWIP NVVGRPFSLD RSYIEHVQSV TGSEPLQKML

KAMA
Length:1,904
Mass (Da):210,940
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBF577222C8B2732
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KB446546 Genomic DNA Translation: EME39032.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EME39032; EME39032; DOTSEDRAFT_181128

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB446546 Genomic DNA Translation: EME39032.1

3D structure databases

SMRiM2XHU6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi64363.EME39032

Genome annotation databases

EnsemblFungiiEME39032; EME39032; DOTSEDRAFT_181128

Phylogenomic databases

eggNOGiENOG502QQJX, Eukaryota
HOGENOMiCLU_000114_5_0_1
OMAiCAGHFRA
OrthoDBi8490at2759

Family and domain databases

Gene3Di3.20.20.70, 1 hit
3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013785, Aldolase_TIM
IPR016452, Fas1/AflB-like
IPR013565, Fas1/AflB-like_central
IPR040883, FAS_meander
IPR003965, Fatty_acid_synthase
IPR029069, HotDog_dom_sf
IPR039569, MaoC-like_dehydrat_N
IPR002539, MaoC-like_dom
IPR032088, SAT
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF08354, DUF1729, 1 hit
PF17951, FAS_meander, 1 hit
PF13452, MaoC_dehydrat_N, 1 hit
PF01575, MaoC_dehydratas, 1 hit
PF16073, SAT, 1 hit
PIRSFiPIRSF005562, FAS_yeast_beta, 1 hit
PRINTSiPR01483, FASYNTHASE
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SUPFAMiSSF52151, SSF52151, 2 hits
SSF54637, SSF54637, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEXB_DOTSN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M2XHU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: May 1, 2013
Last modified: February 10, 2021
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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