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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Treponema denticola US-Trep
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Activity regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16NAD; via amide nitrogenUniRule annotation1
Binding sitei37NADUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei145NADUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei155Allosteric activatorUniRule annotation1
Binding sitei170Allosteric activatorUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei233SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 82NADUniRule annotation2
Nucleotide bindingi120 – 122NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzymeUniRule annotation, OxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
ORF Names:HMPREF9728_00427Imported
OrganismiTreponema denticola US-TrepImported
Taxonomic identifieri999440 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000011655 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 144Ldh_1_NInterPro annotationAdd BLAST138
Domaini147 – 313Ldh_1_CInterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 125Substrate bindingUniRule annotation4
Regioni150 – 153Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

M2SJN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEKKRKVTV VGAGAVGSTF AYALAQSGYA DEIAITDMNK NFAEGQALDL
60 70 80 90 100
VQGLPFLPQV DIHAGDKADY ADSDIVVVTA GAKQQSGETR IDLLKRNASI
110 120 130 140 150
ITGIAKDIAE SGCSGVMLIV SNPVDILTRA ALKASGWERG RVIGSGTVLD
160 170 180 190 200
TARFRYTLSK ECGVDARNIH GYILGEHGDS EFAAWSMTSV AGRRIDEYCS
210 220 230 240 250
GGVCSSGLHF DKAKILEEVR NSAYHIIDYK GSTYFAVGLA LTRIAGAILR
260 270 280 290 300
NEHSILSVSM TLDGEFGLKD VCLSVPCIVG RSGAERVIES DLPADEQAAL
310
EASAKRLKEA FTEVN
Length:315
Mass (Da):33,557
Last modified:May 1, 2013 - v1
Checksum:i31F80B3B0BC56AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGEB01000003 Genomic DNA Translation: EMD57366.1
RefSeqiWP_002676696.1, NZ_KB454450.1

Genome annotation databases

EnsemblBacteriaiEMD57366; EMD57366; HMPREF9728_00427
PATRICifig|999440.3.peg.432

Similar proteinsi

Entry informationi

Entry nameiM2SJN3_TREDN
AccessioniPrimary (citable) accession number: M2SJN3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: September 12, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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