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Protein

Succinate--CoA ligase [ADP-forming] subunit beta

Gene

sucC

Organism
Desulfocapsa sulfexigens (strain DSM 10523 / SB164P1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.UniRule annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit beta (sucC), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPUniRule annotation1
Binding sitei98ATPUniRule annotation1
Binding sitei101ATP; via amide nitrogenUniRule annotation1
Binding sitei106ATPUniRule annotation1
Metal bindingi198MagnesiumUniRule annotation1
Metal bindingi212MagnesiumUniRule annotation1
Binding sitei263Substrate; shared with subunit alphaUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 54ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSUL1167006:G1HFC-1577-MONOMER
UniPathwayi
UPA00223;UER00999

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit betaUniRule annotation (EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit betaUniRule annotation
Short name:
SCS-betaUniRule annotation
Gene namesi
Name:sucCUniRule annotation
Ordered Locus Names:UWK_01584Imported
OrganismiDesulfocapsa sulfexigens (strain DSM 10523 / SB164P1)Imported
Taxonomic identifieri1167006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfocapsa
Proteomesi
  • UP000011721 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 228ATP-graspInterPro annotationAdd BLAST220

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 322Substrate binding; shared with subunit alphaUniRule annotation3

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase beta subunit family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01903
OMAiLCMDAKF
OrthoDBiPOG091H050Y

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.50.261, 1 hit
HAMAPiMF_00558 Succ_CoA_beta, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013650 ATP-grasp_succ-CoA_synth-type
IPR013815 ATP_grasp_subdomain_1
IPR005811 CoA_ligase
IPR005809 Succ_CoA_synthase_bsu
IPR016102 Succinyl-CoA_synth-like
PANTHERiPTHR11815 PTHR11815, 1 hit
PfamiView protein in Pfam
PF08442 ATP-grasp_2, 1 hit
PF00549 Ligase_CoA, 1 hit
PIRSFiPIRSF001554 SucCS_beta, 1 hit
SUPFAMiSSF52210 SSF52210, 1 hit
TIGRFAMsiTIGR01016 sucCoAbeta, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

M1P904-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIHEYQAKE LFRTYGIPVP EGKICTVRED ISSLLEGITM PVAVKAQILA
60 70 80 90 100
GGRGKGGGVV LARTVAEAQK AAERILGMQL VTKQTGAEGT EVKTILFEQG
110 120 130 140 150
VNIAKELYLS ILVDRDRSGI VIIASRDGGM EIETVAAETP ERIITVHVNP
160 170 180 190 200
LLGLQGYQIR ELIFGLEIAP AVTKCFSSII RKLFTLFIQS DCSLVEINPL
210 220 230 240 250
VITGENTVIA LDAKMDIDSN SLFRHPDILA MHDSSEEDEF EATAASHGLN
260 270 280 290 300
YIRLNGTIGS MVNGAGLAMA TMDLIKQAGL EPANFLDVGG GASAEMVENG
310 320 330 340 350
FRIILSDPKI RGIFINIFGG ILRCDILAEG VVAAARKIGL SLPVVVRMEG
360 370 380
TNVEAGRRIL AESGLSLSNA KDLNHAAELL AAI
Length:383
Mass (Da):40,947
Last modified:May 1, 2013 - v1
Checksum:i0FEC7B973814849B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003985 Genomic DNA Translation: AGF78142.1
RefSeqiWP_015403833.1, NC_020304.1

Genome annotation databases

EnsemblBacteriaiAGF78142; AGF78142; UWK_01584
KEGGidsf:UWK_01584
PATRICifig|1167006.5.peg.1744

Similar proteinsi

Entry informationi

Entry nameiM1P904_DESSD
AccessioniPrimary (citable) accession number: M1P904
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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