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Entry version 37 (08 May 2019)
Sequence version 1 (01 May 2013)
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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit E

Gene

gatE

Organism
Sulfolobus acidocaldarius N8
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseUniRule annotation, TransferaseImported
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SACI1028566:G1HF3-1309-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit EUniRule annotation (EC:6.3.5.-UniRule annotation)
Short name:
Glu-ADT subunit EUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gatEUniRule annotation
ORF Names:SacN8_06585Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSulfolobus acidocaldarius N8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1028566 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of GatD and GatE.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
M1IRA3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 628GatB_YqeyInterPro annotationAdd BLAST142

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GatB/GatE family. GatE subfamily.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K03330

Database of Orthologous Groups

More...
OrthoDBi
35861at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.410, 1 hit
1.10.150.380, 1 hit
3.30.1360.30, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00588 GatE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017959 Asn/Gln-tRNA_amidoTrfase_suB/E
IPR006075 Asn/Gln-tRNA_Trfase_suB/E_cat
IPR018027 Asn/Gln_amidotransferase
IPR003789 Asn/Gln_tRNA_amidoTrase-B-like
IPR004115 GAD-like_sf
IPR029351 GAD_dom
IPR042114 GatB_C_1
IPR023168 GatB_Yqey_C_2
IPR004414 GatE
IPR017958 Gln-tRNA_amidoTrfase_suB_CS
IPR014746 Gln_synth/guanido_kin_cat_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11659 PTHR11659, 1 hit
PTHR11659:SF2 PTHR11659:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02938 GAD, 1 hit
PF02934 GatB_N, 1 hit
PF02637 GatB_Yqey, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00845 GatB_Yqey, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55261 SSF55261, 1 hit
SSF55931 SSF55931, 1 hit
SSF89095 SSF89095, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00134 gatE_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01234 GATB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M1IRA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTELDYSKLG LKVGLEIHQQ LNTNKKLFCD CSTTLDEKHH GTLQRYLRPS
60 70 80 90 100
FSEIGEIDTA ALFEWQKGKK YLYQIPFNSC LVEADEEPPH GLNREALAVV
110 120 130 140 150
LAVAMSLESN IVDEIYVMRK IVIDGSDTTG FQRTSIVAMG GQVIVEGKKI
160 170 180 190 200
GIQTIALEED AARKISESAN ETMYSLDRLG IPLIEISTAP DITTPEEAEK
210 220 230 240 250
VAFRIGQLLR LTGKVKRGIG TIRQDLNVSI QGGVKTEIKG VQRLELIPEI
260 270 280 290 300
IKNEARRQYE LLKIKDELVN KRGLSKTIVE NEIKELELTH LFRNTNSKII
310 320 330 340 350
KKELEKGGLI YGIKFKGFKG IFGRELMPNR RFGTEIADYV RALAELGGIF
360 370 380 390 400
HSDELPNYGI TSEEVESVKK ELGIGENDGF VLVIGDKEKL KVAITKIKER
410 420 430 440 450
VLYAFVGVPK ETRVALDDGT TKFMRPQPGS ARMYPETDII PIKIDESILN
460 470 480 490 500
FAKSFVPENP ETKLRKLIEM GLSKELATEI LNSPRLDLFE ELSKKYSPKV
510 520 530 540 550
SPIVIATTLE NYIKYAKSKG GDISVITDEV IEEIINALYN DKISKDSIQE
560 570 580 590 600
ILVDYSTSKK PIRNIVDNYA KITDEELNRI IDKILDENKD IINQKGEKAF
610 620 630
NVIIGKVMNV VKGRAEGKKV VDTLKLKMKN YPRT
Length:634
Mass (Da):71,325
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA0D3F03743C799D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002817 Genomic DNA Translation: AGE71282.1

NCBI Reference Sequences

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RefSeqi
WP_015385605.1, NC_020246.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AGE71282; AGE71282; SacN8_06585

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3473463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sacn:SacN8_06585

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1028566.6.peg.1295

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002817 Genomic DNA Translation: AGE71282.1
RefSeqiWP_015385605.1, NC_020246.1

3D structure databases

SMRiM1IRA3
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiAGE71282; AGE71282; SacN8_06585
GeneIDi3473463
KEGGisacn:SacN8_06585
PATRICifig|1028566.6.peg.1295

Phylogenomic databases

KOiK03330
OrthoDBi35861at2157

Enzyme and pathway databases

BioCyciSACI1028566:G1HF3-1309-MONOMER

Family and domain databases

Gene3Di1.10.10.410, 1 hit
1.10.150.380, 1 hit
3.30.1360.30, 1 hit
HAMAPiMF_00588 GatE, 1 hit
InterProiView protein in InterPro
IPR017959 Asn/Gln-tRNA_amidoTrfase_suB/E
IPR006075 Asn/Gln-tRNA_Trfase_suB/E_cat
IPR018027 Asn/Gln_amidotransferase
IPR003789 Asn/Gln_tRNA_amidoTrase-B-like
IPR004115 GAD-like_sf
IPR029351 GAD_dom
IPR042114 GatB_C_1
IPR023168 GatB_Yqey_C_2
IPR004414 GatE
IPR017958 Gln-tRNA_amidoTrfase_suB_CS
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11659 PTHR11659, 1 hit
PTHR11659:SF2 PTHR11659:SF2, 1 hit
PfamiView protein in Pfam
PF02938 GAD, 1 hit
PF02934 GatB_N, 1 hit
PF02637 GatB_Yqey, 1 hit
SMARTiView protein in SMART
SM00845 GatB_Yqey, 1 hit
SUPFAMiSSF55261 SSF55261, 1 hit
SSF55931 SSF55931, 1 hit
SSF89095 SSF89095, 1 hit
TIGRFAMsiTIGR00134 gatE_arch, 1 hit
PROSITEiView protein in PROSITE
PS01234 GATB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM1IRA3_9CREN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M1IRA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: May 8, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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