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Entry version 39 (12 Aug 2020)
Sequence version 1 (03 Apr 2013)
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Protein

Protein JOKA2

Gene

JOKA2

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Autophagic substrate that functions as host autophagy cargo receptor (Probable). Requires ATG8 protein expression to be recognized as an autophagic substrate (Probable). Activates ATG8CL-mediated selective autophagy, and contributes to defense against the fungal pathogen Phytophtora infestans (PubMed:26765567, PubMed:29932422).2 Publications2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri441 – 488ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Plant defense, Protein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein JOKA21 Publication
Alternative name(s):
Protein NBR1 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JOKA21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSolanum tuberosum (Potato)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4113 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011115 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi821W → A: Loss of interaction with ATG8CL; when associated with A-824. 1 Publication1
Mutagenesisi824I → A: Loss of interaction with ATG8CL; when associated with A-821. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004473471 – 862Protein JOKA2Add BLAST862

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminal AIM motif) with ATG8CL.

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4113.PGSC0003DMT400046670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M1BJF6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 90PB1PROSITE-ProRule annotationAdd BLAST85
Domaini811 – 860UBAPROSITE-ProRule annotationAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi817 – 824ATG8 interacting motif (AIM)1 Publication8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ATG8 interacting motif (AIM) is required for the interaction with ATG8CL (PubMed:26765567, PubMed:29932422). The AIM motif is required for JOKA2 function as host autophagy cargo receptor (PubMed:26765567, PubMed:29932422).2 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 488ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4351, Eukaryota
KOG4582, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017180_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M1BJF6

KEGG Orthology (KO)

More...
KOi
K17987

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNATDIN

Database of Orthologous Groups

More...
OrthoDBi
991378at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14947, NBR1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR032350, N_BRCA1_central
IPR000270, PB1_dom
IPR015940, UBA
IPR009060, UBA-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16158, N_BRCA1_IG, 1 hit
PF00564, PB1, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666, PB1, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745, PB1, 1 hit
PS50030, UBA, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M1BJF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMESSIVIK VKYEETLRRF NACVINEKLD LDIGGLRDKI IQLFNFAHDA
60 70 80 90 100
ELTLTYIDED GDVVTLVDDE DLQDVMRQDL NPLRISARLN AGERSGRASA
110 120 130 140 150
RSSGNSTPLR SPRVQPPFLN LNSRVSDVLK YIPEPLRESV MKVCSDMTAS
160 170 180 190 200
ASSSAPILAE LVDAMSEMGL SYYQNQASGS QAVKEAGSCS GISKGNTKSA
210 220 230 240 250
DGGMPNVKIG ESSPKKNRPL TALHGEPKPN ASNEAVDASV KLVCKSETLE
260 270 280 290 300
GDRTEDLSSS FKGSKAQTSL VNSLEKDKKF DVRSLDGRTI GYAYVRNSPI
310 320 330 340 350
PPEKTSDEQP SKGHPVAKPV DLGGSASSSK VKQCNWDSPN ADSSGSSINM
360 370 380 390 400
PYDGFTPSGL VHLNTVNVND SHNAGSSGSS MKMPYDGFRP AVRHLGPLIP
410 420 430 440 450
VNACPFSGVP TVNNPIPPQN FSFEVPLKRS HNHSDGTGTI FHKGVRCDGC
460 470 480 490 500
GVHPITGPRF ISKVKENYDL CSICFAEMGN DADYIRMDRP LTYPNPWSFK
510 520 530 540 550
SLHDLHGRLR PRPPTVPQVI RGFGLKAGRP KLDSRFIQDV NVLDGTIMAP
560 570 580 590 600
LTRFTKIWRM KNNGNLVWPQ GTQLVWIGGD KLSDRFSVEL EITTAGLAVD
610 620 630 640 650
QELDVAVDFT APEHPGRYIS YWRLASASGQ KFGQRVWVLI QVDALLSVPK
660 670 680 690 700
KGLVHEAFQG LNLNLPPAGS GVSGPDIINV NSEPQNVLPE PKSSSTMELV
710 720 730 740 750
DSVAEVNQNK EQEAKFPIND SLLVGFGDKS SSPSASGSPI SYPVIDLTEK
760 770 780 790 800
PSADSSMQPS AAVAMQAPLQ DARGNFEVEM SLLQELEEMG FKQVDLNKEI
810 820 830 840 850
LRKNEYDLEQ SVDDLCGVAE WDPILEELKE MGFCDKEMNK KLLKKNNGSI
860
KRVVMDLIAG EQ
Length:862
Mass (Da):93,977
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21B6EAB982209C1A
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_006344472.1, XM_006344410.2
XP_015162877.1, XM_015307391.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
PGSC0003DMT400046670; PGSC0003DMT400046670; PGSC0003DMG400018122

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102582603

Gramene; a comparative resource for plants

More...
Gramenei
PGSC0003DMT400046670; PGSC0003DMT400046670; PGSC0003DMG400018122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sot:102582603

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_006344472.1, XM_006344410.2
XP_015162877.1, XM_015307391.1

3D structure databases

SMRiM1BJF6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400046670

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400046670; PGSC0003DMT400046670; PGSC0003DMG400018122
GeneIDi102582603
GrameneiPGSC0003DMT400046670; PGSC0003DMT400046670; PGSC0003DMG400018122
KEGGisot:102582603

Phylogenomic databases

eggNOGiKOG4351, Eukaryota
KOG4582, Eukaryota
HOGENOMiCLU_017180_0_0_1
InParanoidiM1BJF6
KOiK17987
OMAiQNATDIN
OrthoDBi991378at2759

Family and domain databases

CDDicd14947, NBR1_like, 1 hit
Gene3Di2.60.40.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR032350, N_BRCA1_central
IPR000270, PB1_dom
IPR015940, UBA
IPR009060, UBA-like_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF16158, N_BRCA1_IG, 1 hit
PF00564, PB1, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00666, PB1, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745, PB1, 1 hit
PS50030, UBA, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJOKA2_SOLTU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M1BJF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 5, 2019
Last sequence update: April 3, 2013
Last modified: August 12, 2020
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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