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UniProtKB - M0RBF1 (M0RBF1_RAT)

>tr|M0RBF1|M0RBF1_RAT Complement C3 OS=Rattus norvegicus OX=10116 GN=C3 PE=1 SV=1
MGPTSGSQLLVLLLLLASSLLALGSPMYSIITPNVLRLESEETFILEAHDAQGDVPVTVT
VQDFLKKQVLTSEKTVLTGATGHLNRVSIKIPASKEFNADKGHKYVTVVANFGATVVEKA
VLVSFQSGYLFIQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDIL
SSHNQYGILPLSWNIPELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTE
KFYYIDDPKGLEVSITARFLYGKNVDGTAFVIFGVQDEDKKISLAQSLTRVLIEDGSGEA
VLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKT
PKFFKPAMPFDLMVFVTNPDGSPARRVPVVTQGSDAQALTQDDGVAKLSVNTPNNRQPLT
ITVRTKKEGIPDARQATRTMQAQPYSTMHNSNNYLHLSVSRVELKPGDNLNVNFHLRTDA
GQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRLVAYYTLIGAN
GQREVVADSVWVDVKDSCVGTLVVKGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKG
VFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNYAGVFMDAGLTFKTNQGLQTDQREDPE
CAKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMKYSCQRRARLITQGESC
LKAFMDCCNYITKLREQHRRDHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKE
PEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVADPYEITVMQDFFIDLRLPYSVV
RNEQVEIRAVLFNYREQEKLKVRVELLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVI
VPLKIGLQEVEVKAAVFNHFISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLGQGGVQRE
DVPAADLSDQVPDTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTP
TVIAVHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPPSTWLTA
YVVKVFSLAANLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEAD
VSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMN
KLEEPYLTKFLNTAKDRNRWEEPGQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQR
YYGGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLR
SEETKQNEGFSLTAKGKGQGTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETAKKPQDA
KSSMILDICTRYLGDVDATMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSN
KNTLIIYLEKISHSEEDCLSFKVHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDG
MLSKLCHNEMCRCAEENCFMHQSQDQVSLNERLDKACEPGVDYVYKTKLTTIELSDDFDE
YIMTIEQVIKSGSDEVQAGQERRFISHVKCRNALKLQKGKQYLMWGLSSDLWGEKPNTSY
IIGKDTWVEHWPEAEECQDQKNQKQCEDLGAFTETMVVFGCPN

Entry version 75 (19 Jan 2022)
Sequence version 1 (03 Apr 2013)
Previous versions | rss

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Protein

Complement C3

Gene

C3

Organism

Rattus norvegicus (Rat)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as a chemoattractant for neutrophils in chronic inflammation.

ARBA annotation

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.

ARBA annotation

GO - Molecular functionⁱ

C5L2 anaphylatoxin chemotactic receptor binding Source: Ensembl
endopeptidase inhibitor activity Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

amyloid-beta clearance Source: Ensembl
cell surface receptor signaling pathway involved in cell-cell signaling Source: Ensembl
complement activation, alternative pathway Source: UniProtKB-KW
complement activation, classical pathway Source: UniProtKB-KW
complement-dependent cytotoxicity Source: Ensembl
complement-mediated synapse pruning Source: Ensembl
inflammatory response Source: UniProtKB-KW
neuron remodeling Source: Ensembl
oviduct epithelium development Source: Ensembl
positive regulation of activation of membrane attack complex Source: Ensembl
positive regulation of angiogenesis Source: Ensembl
positive regulation of apoptotic cell clearance Source: Ensembl
positive regulation of glucose transmembrane transport Source: Ensembl
positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
positive regulation of lipid storage Source: Ensembl
positive regulation of phagocytosis, engulfment Source: Ensembl
positive regulation of protein phosphorylation Source: Ensembl
positive regulation of receptor-mediated endocytosis Source: Ensembl
positive regulation of type IIa hypersensitivity Source: Ensembl
positive regulation of vascular endothelial growth factor production Source: Ensembl
regulation of triglyceride biosynthetic process Source: Ensembl
response to bacterium Source: Ensembl
vertebrate eye-specific patterning Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement alternate pathwayARBA annotation, Complement pathwayARBA annotation, Immunity, Inflammatory responseARBA annotation, Innate immunity

Biological process

Complement alternate pathwayARBA annotation, Complement pathwayARBA annotation, Immunity, Inflammatory responseARBA annotation, Innate immunity

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I39.950

MEROPSⁱ

I39.950

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement C3ARBA annotation
Gene namesⁱ	Name:C3Imported ORF Names:rCG_45082Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 9

Organism-specific databases

Rat genome database More...RGDⁱ	2232, C3

RGDⁱ

2232, C3

Keywords - Cellular componentⁱ

SecretedARBA annotation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_5014101302	25 – 1663	Complement C3Sequence analysisAdd BLAST		1639

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	558 ↔ 816	Interchain (between beta and alpha chains)UniRule annotation
Disulfide bondⁱ	626 ↔ 661	UniRule annotation
Disulfide bondⁱ	693 ↔ 720	UniRule annotation
Disulfide bondⁱ	694 ↔ 727	UniRule annotation
Disulfide bondⁱ	707 ↔ 728	UniRule annotation
Disulfide bondⁱ	873 ↔ 1513	UniRule annotation
Cross-linkⁱ	1010 ↔ 1013	Isoglutamyl cysteine thioester (Cys-Gln)UniRule annotation
Disulfide bondⁱ	1101 ↔ 1158	UniRule annotation
Disulfide bondⁱ	1358 ↔ 1489	UniRule annotation
Disulfide bondⁱ	1389 ↔ 1458	UniRule annotation
Disulfide bondⁱ	1506 ↔ 1511	UniRule annotation
Disulfide bondⁱ	1518 ↔ 1590	UniRule annotation
Disulfide bondⁱ	1537 ↔ 1661	UniRule annotation
Disulfide bondⁱ	1637 ↔ 1646	UniRule annotation

Keywords - PTMⁱ

Cleavage on pair of basic residuesARBA annotation, Disulfide bondUniRule annotationARBA annotation, Thioester bondUniRule annotationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000046834, Expressed in liver and 21 other tissues

Bgeeⁱ

ENSRNOG00000046834, Expressed in liver and 21 other tissues

Interactionⁱ

GO - Molecular functionⁱ

C5L2 anaphylatoxin chemotactic receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	M0RBF1, 2 interactors

IntActⁱ

M0RBF1, 2 interactors

Structureⁱ

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	693 – 728	Anaphylatoxin-likeInterPro annotationAdd BLAST		36
Domainⁱ	1518 – 1661	NTRInterPro annotationAdd BLAST		144

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154063
HOGENOMⁱ	CLU_001634_4_0_1
OMAⁱ	QATNTMQ
Database of Orthologous Groups More...OrthoDBⁱ	23785at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00017, ANATO, 1 hit cd03583, NTR_complement_C3, 1 hit
Gene3Dⁱ	2.40.50.120, 1 hit 2.60.40.10, 2 hits 2.60.40.690, 1 hit
InterProⁱ	View protein in InterPro IPR009048, A-macroglobulin_rcpt-bd IPR036595, A-macroglobulin_rcpt-bd_sf IPR011625, A2M_N_BRD IPR011626, Alpha-macroglobulin_TED IPR000020, Anaphylatoxin/fibulin IPR018081, Anaphylatoxin_comp_syst IPR001840, Anaphylatoxn_comp_syst_dom IPR041425, C3/4/5_MG1 IPR035711, Complement_C3-like IPR013783, Ig-like_fold IPR001599, Macroglobln_a2 IPR019742, MacrogloblnA2_CS IPR002890, MG2 IPR041555, MG3 IPR040839, MG4 IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035815, NTR_complement_C3 IPR008930, Terpenoid_cyclase/PrenylTrfase IPR008993, TIMP-like_OB-fold
PANTHERⁱ	PTHR11412:SF81, PTHR11412:SF81, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00207, A2M, 1 hit PF07703, A2M_BRD, 1 hit PF07677, A2M_recep, 1 hit PF01821, ANATO, 1 hit PF17790, MG1, 1 hit PF01835, MG2, 1 hit PF17791, MG3, 1 hit PF17789, MG4, 1 hit PF01759, NTR, 1 hit PF07678, TED_complement, 1 hit
PRINTSⁱ	PR00004, ANAPHYLATOXN
SMARTⁱ	View protein in SMART SM01360, A2M, 1 hit SM01359, A2M_N_2, 1 hit SM01361, A2M_recep, 1 hit SM00104, ANATO, 1 hit SM00643, C345C, 1 hit
SUPFAMⁱ	SSF47686, SSF47686, 1 hit SSF48239, SSF48239, 1 hit SSF49410, SSF49410, 1 hit SSF50242, SSF50242, 1 hit
PROSITEⁱ	View protein in PROSITE PS00477, ALPHA_2_MACROGLOBULIN, 1 hit PS01177, ANAPHYLATOXIN_1, 1 hit PS01178, ANAPHYLATOXIN_2, 1 hit PS50189, NTR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

M0RBF1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPTSGSQLL VLLLLLASSL LALGSPMYSI ITPNVLRLES EETFILEAHD 
        60         70         80         90        100
AQGDVPVTVT VQDFLKKQVL TSEKTVLTGA TGHLNRVSIK IPASKEFNAD 
       110        120        130        140        150
KGHKYVTVVA NFGATVVEKA VLVSFQSGYL FIQTDKTIYT PGSTVFYRIF 
       160        170        180        190        200
TVDNNLLPVG KTVVIVIETP DGVPIKRDIL SSHNQYGILP LSWNIPELVN 
       210        220        230        240        250
MGQWKIRAFY EHAPKQTFSA EFEVKEYVLP SFEVLVEPTE KFYYIDDPKG 
       260        270        280        290        300
LEVSITARFL YGKNVDGTAF VIFGVQDEDK KISLAQSLTR VLIEDGSGEA 
       310        320        330        340        350
VLSRKVLMDG VRPSSPEALV GKSLYVSVTV ILHSGSDMVE AERSGIPIVT 
       360        370        380        390        400
SPYQIHFTKT PKFFKPAMPF DLMVFVTNPD GSPARRVPVV TQGSDAQALT 
       410        420        430        440        450
QDDGVAKLSV NTPNNRQPLT ITVRTKKEGI PDARQATRTM QAQPYSTMHN 
       460        470        480        490        500
SNNYLHLSVS RVELKPGDNL NVNFHLRTDA GQEAKIRYYT YLVMNKGKLL 
       510        520        530        540        550
KAGRQVREPG QDLVVLSLPI TPEFIPSFRL VAYYTLIGAN GQREVVADSV 
       560        570        580        590        600
WVDVKDSCVG TLVVKGDPRD NRQPAPGHQT TLRIEGNQGA RVGLVAVDKG 
       610        620        630        640        650
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLTFKTNQG 
       660        670        680        690        700
LQTDQREDPE CAKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD 
       710        720        730        740        750
IPMKYSCQRR ARLITQGESC LKAFMDCCNY ITKLREQHRR DHVLGLARSD 
       760        770        780        790        800
VDEDIIPEED IISRSHFPES WLWTIEELKE PEKNGISTKV MNIFLKDSIT 
       810        820        830        840        850
TWEILAVSLS DKKGICVADP YEITVMQDFF IDLRLPYSVV RNEQVEIRAV 
       860        870        880        890        900
LFNYREQEKL KVRVELLHNP AFCSMATAKK RYYQTIEIPP KSSVAVPYVI 
       910        920        930        940        950
VPLKIGLQEV EVKAAVFNHF ISDGVKKILK VVPEGMRVNK TVAVRTLDPE 
       960        970        980        990       1000
HLGQGGVQRE DVPAADLSDQ VPDTDSETRI LLQGTPVAQM AEDAVDGERL 
      1010       1020       1030       1040       1050
KHLIVTPSGC GEQNMIGMTP TVIAVHYLDQ TEQWEKFGLE KRQEALELIK 
      1060       1070       1080       1090       1100
KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA YVVKVFSLAA NLIAIDSQVL 
      1110       1120       1130       1140       1150
CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNTKEAD VSLTAFVLIA 
      1160       1170       1180       1190       1200
LQEARDICEG QVNSLPGSIN KAGEYLEASY LNLQRPYTVA IAGYALALMN 
      1210       1220       1230       1240       1250
KLEEPYLTKF LNTAKDRNRW EEPGQQLYNV EATSYALLAL LLLKDFDSVP 
      1260       1270       1280       1290       1300
PVVRWLNEQR YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSLHL 
      1310       1320       1330       1340       1350
PSRSSPTVFR LLWESGSLLR SEETKQNEGF SLTAKGKGQG TLSVVTVYHA 
      1360       1370       1380       1390       1400
KVKGKATCKK FDLRVTIKPA PETAKKPQDA KSSMILDICT RYLGDVDATM 
      1410       1420       1430       1440       1450
SILDISMMTG FIPDTNDLEL LSSGVDRYIS KYEMDKAFSN KNTLIIYLEK 
      1460       1470       1480       1490       1500
ISHSEEDCLS FKVHQFFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG 
      1510       1520       1530       1540       1550
MLSKLCHNEM CRCAEENCFM HQSQDQVSLN ERLDKACEPG VDYVYKTKLT 
      1560       1570       1580       1590       1600
TIELSDDFDE YIMTIEQVIK SGSDEVQAGQ ERRFISHVKC RNALKLQKGK 
      1610       1620       1630       1640       1650
QYLMWGLSSD LWGEKPNTSY IIGKDTWVEH WPEAEECQDQ KNQKQCEDLG 
      1660 
AFTETMVVFG CPN

Length:1,663

Mass (Da):186,324

Last modified:April 3, 2013 - v1

Checksum:ⁱ37CCB03B78072FAF

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

P01026	CO3_RAT	Complement C3 Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c, C3bc (Neutrophil chemotactic factor-2, ENCF-2) ; Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1, ENCF-1) ; Acylation stimulating protein, ASP (C3adesArg) ; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]	C3	1,663	Annotation score:
M0RBJ7	M0RBJ7_RAT	Complement C3 Complement C3	C3	1,662	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07066499 Genomic DNA No translation available. CH474092 Genomic DNA Translation: EDL83571.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058690.2, NM_016994.2

Genome annotation databases

Ensemblⁱ	ENSRNOT00000073042; ENSRNOP00000066885; ENSRNOG00000046834
GeneIDⁱ	24232
KEGGⁱ	rno:24232

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
M0RBF1	(mimic poison frog) hypothetical protein		mimic poison frog		728	UniRef100_M0RBF1

Protein	Similar proteins		Species	Score	Length	Source
M0RBF1	Complement C3	)	RAT		1663	UniRef90_P01026
(mimic poison frog) hypothetical protein		mimic poison frog		728
+4

Protein	Similar proteins		Species	Score	Length	Source
M0RBF1	Complement C3	)	HUMAN		1663	UniRef50_P01024
Complement C3	)	RAT		1663
Complement C3		CAVPO		1666
Complement C3	)	BOVIN		1661
Complement C3	)	MOUSE		1663
+319

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07066499 Genomic DNA No translation available. CH474092 Genomic DNA Translation: EDL83571.1
RefSeqⁱ	NP_058690.2, NM_016994.2

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

IntActⁱ	M0RBF1, 2 interactors

IntActⁱ

M0RBF1, 2 interactors

Protein family/group databases

MEROPSⁱ	I39.950

MEROPSⁱ

I39.950

Genome annotation databases

Ensemblⁱ	ENSRNOT00000073042; ENSRNOP00000066885; ENSRNOG00000046834
GeneIDⁱ	24232
KEGGⁱ	rno:24232

Organism-specific databases

CTDⁱ	718
RGDⁱ	2232, C3

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000154063
HOGENOMⁱ	CLU_001634_4_0_1
OMAⁱ	QATNTMQ
OrthoDBⁱ	23785at2759

Gene expression databases

Bgeeⁱ	ENSRNOG00000046834, Expressed in liver and 21 other tissues

Bgeeⁱ

ENSRNOG00000046834, Expressed in liver and 21 other tissues

Family and domain databases

CDDⁱ	cd00017, ANATO, 1 hit cd03583, NTR_complement_C3, 1 hit
Gene3Dⁱ	2.40.50.120, 1 hit 2.60.40.10, 2 hits 2.60.40.690, 1 hit
InterProⁱ	View protein in InterPro IPR009048, A-macroglobulin_rcpt-bd IPR036595, A-macroglobulin_rcpt-bd_sf IPR011625, A2M_N_BRD IPR011626, Alpha-macroglobulin_TED IPR000020, Anaphylatoxin/fibulin IPR018081, Anaphylatoxin_comp_syst IPR001840, Anaphylatoxn_comp_syst_dom IPR041425, C3/4/5_MG1 IPR035711, Complement_C3-like IPR013783, Ig-like_fold IPR001599, Macroglobln_a2 IPR019742, MacrogloblnA2_CS IPR002890, MG2 IPR041555, MG3 IPR040839, MG4 IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035815, NTR_complement_C3 IPR008930, Terpenoid_cyclase/PrenylTrfase IPR008993, TIMP-like_OB-fold
PANTHERⁱ	PTHR11412:SF81, PTHR11412:SF81, 1 hit
Pfamⁱ	View protein in Pfam PF00207, A2M, 1 hit PF07703, A2M_BRD, 1 hit PF07677, A2M_recep, 1 hit PF01821, ANATO, 1 hit PF17790, MG1, 1 hit PF01835, MG2, 1 hit PF17791, MG3, 1 hit PF17789, MG4, 1 hit PF01759, NTR, 1 hit PF07678, TED_complement, 1 hit
PRINTSⁱ	PR00004, ANAPHYLATOXN
SMARTⁱ	View protein in SMART SM01360, A2M, 1 hit SM01359, A2M_N_2, 1 hit SM01361, A2M_recep, 1 hit SM00104, ANATO, 1 hit SM00643, C345C, 1 hit
SUPFAMⁱ	SSF47686, SSF47686, 1 hit SSF48239, SSF48239, 1 hit SSF49410, SSF49410, 1 hit SSF50242, SSF50242, 1 hit
PROSITEⁱ	View protein in PROSITE PS00477, ALPHA_2_MACROGLOBULIN, 1 hit PS01177, ANAPHYLATOXIN_1, 1 hit PS01178, ANAPHYLATOXIN_2, 1 hit PS50189, NTR, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M0RBF1_RAT
Accessionⁱ	M0RBF1Primary (citable) accession number: M0RBF1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 3, 2013
	Last sequence update:	April 3, 2013
	Last modified:	January 19, 2022
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - M0RBF1 (M0RBF1_RAT)

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Complement C3

C3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ