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Protein
Submitted name:

Deltex E3 ubiquitin ligase 1

Gene

Dtx1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-2122948 Activated NOTCH1 Transmits Signal to the Nucleus

Names & Taxonomyi

Protein namesi
Submitted name:
Deltex E3 ubiquitin ligase 1Imported
Gene namesi
Name:Dtx1Imported
Synonyms:LOC687424Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1585380 Dtx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiM0RA58
PRIDEiM0RA58

Expressioni

Gene expression databases

BgeeiENSRNOG00000050848 Expressed in 9 organ(s), highest expression level in brain

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066399

Structurei

3D structure databases

ProteinModelPortaliM0RA58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 94WWEInterPro annotationAdd BLAST81
Domaini95 – 171WWEInterPro annotationAdd BLAST77
Domaini418 – 479RING-typeInterPro annotationAdd BLAST62

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IEMS Eukaryota
ENOG4111EY2 LUCA
GeneTreeiENSGT00440000035370
InParanoidiM0RA58
KOiK06058
OMAiHGHHALT
OrthoDBiEOG091G04KU

Family and domain databases

CDDicd09633 Deltex_C, 1 hit
Gene3Di3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits
InterProiView protein in InterPro
IPR039396 Deltex_C
IPR039399 Deltex_C_sf
IPR039398 Deltex_fam
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12622 PTHR12622, 1 hit
PfamiView protein in Pfam
PF02825 WWE, 2 hits
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00678 WWE, 2 hits
SUPFAMiSSF117839 SSF117839, 2 hits
PROSITEiView protein in PROSITE
PS50918 WWE, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

M0RA58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRPGQGVMV PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN
60 70 80 90 100
VLKEDARGSV VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS
110 120 130 140 150
SAPGKGIVWE WENDGGAWTA YDMDICITIQ NAYEKQHPWL DLSSLGFCYL
160 170 180 190 200
IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT VGSIPKSQSW PVGASSGQPC
210 220 230 240 250
SCQQCLLVNS TRAASNAILA SQRRKAPIAP AAPPAPPPPP PPLPPGGPPS
260 270 280 290 300
ALVVRPSATF AGAALWAAPA AGPTEPAPPP GVPPRSPSAP NGAPTPGQNN
310 320 330 340 350
LSRPGPQRST SVSARASIPP GVPALPVKNL NGTGPVHPAL AGMTGILLCA
360 370 380 390 400
AGLPVCLTRA PKPILHPPPV SKSDVKPVPG VPGVCRKTKK KHLKKSKNPE
410 420 430 440 450
DVVRRYMQKV KNPPDEDCTI CMERLVTASG YEGVLRNKSV RPELVGRLGR
460 470 480 490 500
CGHMYHLLCL VAMYSNGNKD GSLQCPTCKA IYGEKTGTQP PGKMEFHLIP
510 520 530 540 550
HSLPGFADTQ TIRIVYDIPT GIQGPEHPNP GKKFTARGFP RHCYLPNNEK
560 570 580 590 600
GRKVLRLLIT AWERRLIFTI GTSNTTGESD TVVWNEIHHK TEFGSNLTGH
610 620
GYPDASYLDN VLAELTAQGV SEAMAKA
Length:627
Mass (Da):68,119
Last modified:April 3, 2013 - v1
Checksum:iEEA12B8A3D5EC7FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07036386 Genomic DNA No translation available.
RefSeqiXP_001076559.1, XM_001076559.6
XP_003751241.1, XM_003751193.4

Genome annotation databases

EnsembliENSRNOT00000074974; ENSRNOP00000066399; ENSRNOG00000050848
GeneIDi687424
KEGGirno:687424

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07036386 Genomic DNA No translation available.
RefSeqiXP_001076559.1, XM_001076559.6
XP_003751241.1, XM_003751193.4

3D structure databases

ProteinModelPortaliM0RA58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066399

Proteomic databases

PaxDbiM0RA58
PRIDEiM0RA58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074974; ENSRNOP00000066399; ENSRNOG00000050848
GeneIDi687424
KEGGirno:687424

Organism-specific databases

CTDi1840
RGDi1585380 Dtx1

Phylogenomic databases

eggNOGiENOG410IEMS Eukaryota
ENOG4111EY2 LUCA
GeneTreeiENSGT00440000035370
InParanoidiM0RA58
KOiK06058
OMAiHGHHALT
OrthoDBiEOG091G04KU

Enzyme and pathway databases

ReactomeiR-RNO-2122948 Activated NOTCH1 Transmits Signal to the Nucleus

Gene expression databases

BgeeiENSRNOG00000050848 Expressed in 9 organ(s), highest expression level in brain

Family and domain databases

CDDicd09633 Deltex_C, 1 hit
Gene3Di3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits
InterProiView protein in InterPro
IPR039396 Deltex_C
IPR039399 Deltex_C_sf
IPR039398 Deltex_fam
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12622 PTHR12622, 1 hit
PfamiView protein in Pfam
PF02825 WWE, 2 hits
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00678 WWE, 2 hits
SUPFAMiSSF117839 SSF117839, 2 hits
PROSITEiView protein in PROSITE
PS50918 WWE, 2 hits
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0RA58_RAT
AccessioniPrimary (citable) accession number: M0RA58
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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