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Protein
Submitted name:

Adrenergic receptor, alpha 2a

Gene

Adra2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390696 Adrenoceptors
R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events
R-RNO-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Submitted name:
Adrenergic receptor, alpha 2aImported
Submitted name:
Alpha-2A adrenergic receptorImported
Gene namesi
Name:Adra2aImported
ORF Names:rCG_57546Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2056 Adra2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 73HelicalSequence analysisAdd BLAST25
Transmembranei85 – 104HelicalSequence analysisAdd BLAST20
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei210 – 232HelicalSequence analysisAdd BLAST23
Transmembranei387 – 413HelicalSequence analysisAdd BLAST27
Transmembranei425 – 444HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000047545

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 441G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST377

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
KOiK04138
OMAiIIFIVWV
OrthoDBiEOG091G06VI

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

M0R9R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRQEQPLAE GSFAPMGSLQ PDAGNSSWNG TEAPGGGTRA TPYSLQVTLT
60 70 80 90 100
LVCLAGLLML FTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL
110 120 130 140 150
VIPFSLANEV MGYWYFGKVW CEIYLALDVL FCTSSIVHLC AISLDRYWSI
160 170 180 190 200
TQAIEYNLKR TPRRIKAIIV TVWVISAVIS FPPLISIEKK GAGGGQQPAE
210 220 230 240 250
PSCKINDQKW YVISSSIGSF FAPCLIMILV YVRIYQIAKR RTRVPPSRRG
260 270 280 290 300
PDACSAPPGG ADRRPNGLGP ERGAGTAGAE AEPLPTQLNG APGEPAPTRP
310 320 330 340 350
RDGDALDLEE SSSSEHAERP QGPGKPERGP RAKGKTKASQ VKPGDSLPRR
360 370 380 390 400
GPGAAGPGAS GSGQGEERAG GAKASRWRGR QNREKRFTFV LAVVIGVFVV
410 420 430 440 450
CWFPFFFTYT LIAVGCPVPY QLFNFFFWFG YCNSSLNPVI YTIFNHDFRR
460
AFKKILCRGD RKRIV
Length:465
Mass (Da):50,630
Last modified:April 3, 2013 - v1
Checksum:i50FDE09BC56F4C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006974 Genomic DNA No translation available.
CH473986 Genomic DNA Translation: EDL94449.1
RefSeqiNP_036871.3, NM_012739.3
UniGeneiRn.170171

Genome annotation databases

EnsembliENSRNOT00000071541; ENSRNOP00000066242; ENSRNOG00000047545
GeneIDi25083
KEGGirno:25083

Similar proteinsi

Entry informationi

Entry nameiM0R9R3_RAT
AccessioniPrimary (citable) accession number: M0R9R3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: July 18, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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