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Entry version 52 (12 Aug 2020)
Sequence version 1 (03 Apr 2013)
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Protein

Dynein heavy chain 5, axonemal

Gene

Dnah5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1977 – 1984ATPSequence analysis8
Nucleotide bindingi2259 – 2266ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 5, axonemalCurated
Alternative name(s):
Axonemal beta dynein heavy chain 5
Ciliary dynein heavy chain 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
1560828, Dnah5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004417791 – 3470Dynein heavy chain 5, axonemalAdd BLAST3470

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
M0R8U1

PRoteomics IDEntifications database

More...
PRIDEi
M0R8U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000048363, Expressed in heart and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNAL1 (PubMed:21496787). Consists of at least two heavy chains and a number of intermediate and light chains.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000065896

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M0R8U1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1938StemBy similarityAdd BLAST1938
Regioni1939 – 2161AAA 1By similarityAdd BLAST223
Regioni2221 – 2440AAA 2By similarityAdd BLAST220
Regioni2547 – 2800AAA 3By similarityAdd BLAST254
Regioni2913 – 3167AAA 4By similarityAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3207 – 3241Sequence analysisAdd BLAST35
Coiled coili3434 – 3468Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_9_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M0R8U1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQKRDRY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF17857, AAA_lid_1, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

M0R8U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRIGRRQLW KQSVTRVLTQ RLKEEKEAKR ARLDGRHDYL FAIVASCLDL
60 70 80 90 100
NKPEVEDALL EGNQIERIDQ LFAVGGLRHL MFYYQDVEGA EAGQFGSSGG
110 120 130 140 150
VNPASGKMKK PKVFVTEGKD VALMGACVFF TRADPSKAIT AENIHREVSF
160 170 180 190 200
NTLDTADGGL LNSVRRLLSD IFIPALRASS HGWGELEGLQ DASSIQQEFL
210 220 230 240 250
SSLEGFVGIL SGAQNSLKEK VNLQKCDIVE LKSLKEPMDY LALASNPETV
260 270 280 290 300
EKVECCMRVW IKQMEQILAE NNQLRKEADD VGPRAELEHW KKRLSKFNYL
310 320 330 340 350
LDQLKSPDVK AVLAMLAAAK SKLLKVWRDA DIRVTDAANE AKDNVKYLYT
360 370 380 390 400
LEKCCDPLYS SDPVTMVDAI PTLINAIKMI YSISHYYNTS ERITSLFVKV
410 420 430 440 450
TNQMISACKA HITNNGTATI WSQPQDIVMQ KIAAAIKLKQ GYQCCFQETK
460 470 480 490 500
QKLKQNPSEK QFDFSEMYIF GKFETFHQRL AKIMDIFTTF KTYSVLQDSK
510 520 530 540 550
IEGLEDMVTK YQDVVAGIKK KEYNFLDQRK MDFDQDYDEF CKQTNELHSE
560 570 580 590 600
LQRFMDTTFE KIQSTRQALS TLKKFERLNI PNLGIEAKYQ IVFQNFGTDI
610 620 630 640 650
DMISKLYTKQ KYDPPLARDQ PPIAGKILWA RQLFHRLEQP MQLFQQHPFV
660 670 680 690 700
LRTVEAKPVI RSYNRIAKVL LEFEVLYHRA WLQQIEEIHV GLEASLLVKA
710 720 730 740 750
PGTGQLFVNF DPQILILFRE TQCMSQMGLP VSPFAAALFE KRDMYKKNFS
760 770 780 790 800
DMKMMLSEYQ RVKLKMPPAI EQLMLPHLAR VDEALQPGLA VLTWTSLNIG
810 820 830 840 850
TYLENAFEKI KDLELLLDRI NDLIEFRIHA ILEEMSSVAL CQLPQDDPLT
860 870 880 890 900
CEEFLQMTKD LCVNGAQKLH FKSSLVEEAV NELINMLLDV DVLPEEASEK
910 920 930 940 950
VRHENASPNG DTSGGGEGCA EALASSFNAG TSSLPLTTIA RKKKEMEVLE
960 970 980 990 1000
EARELLSYFN HQNTDALLKV TRNTLEAIRR RIHFSHMINF RDSKGASKVK
1010 1020 1030 1040 1050
QNHLPIFRAS VTLAIPNISM TPALEDIQQT LNKAVECIIS VPKGVRQWSS
1060 1070 1080 1090 1100
ELLSKRKMRE RKMAAVQSNE DSDSDTEVEE SELQETLELA SVNLPIPVQT
1110 1120 1130 1140 1150
QNYYKNISDN KEIVKLVSVL STVISSTKKE VITSMDRFKC YNHIWQKEKE
1160 1170 1180 1190 1200
DTIMTFIAQN PLLSEFESRI LYFQSLEQEI NAEPEYICVG SIALYTADLK
1210 1220 1230 1240 1250
FSLTAETKAW MMVLGRHCNR KYRSEMENIF TVVEEFQKKL NRPIKDLDDI
1260 1270 1280 1290 1300
RIAMAALKEI REQQISTDFQ VGPIEESYAL LNKYGLLVAK EEMDKVDTLR
1310 1320 1330 1340 1350
YAWEKLLARA SDVQNELGAL QPSFRKELIS TVEVFLQDCQ QFYLDYDLNG
1360 1370 1380 1390 1400
PMVSGLKPQE ASDRLIIFQN QFDNIYRKYI TYTGGEELFG LPVTQYPQLL
1410 1420 1430 1440 1450
EIKKQLNLLQ KIYSLYNNVI ETVNSYQDTL WSEVNIEKIN SELLEFQNRC
1460 1470 1480 1490 1500
RKLPRALKDW QAFLDMKKTI DDFSECCPLL EYMASNAMVE RHWQRITTLT
1510 1520 1530 1540 1550
GHSLDVGNET FKLRNIMEVP LLKYKEEIED ICISAVKERD IEQKLKQVIN
1560 1570 1580 1590 1600
EWDNKTLTFS SFKTRGELLL RGDSTSEVIA SMEDSLMLLG SLLSNRYNMP
1610 1620 1630 1640 1650
FKAQIQNWVQ CLSNSTDIIE NWMTVQNLWI YLEAVFVGGD IAKQLPKEAK
1660 1670 1680 1690 1700
RFSNIDKSWV KIMTRAHEIP NVVQCCVGDE TMGQLLPHLL DQLEICQKSL
1710 1720 1730 1740 1750
TGYLEKKRLC FPRFFFVSDP ALLEILGQAS DSHTIQAHLL NVFDNIKTVK
1760 1770 1780 1790 1800
FHDKIYDRIL SISSREGETI ELDKPVMAEG NVEVWLNSLL EESQSSLHLV
1810 1820 1830 1840 1850
IRQAAANIQE SGFQLIEFLS SFPAQVGLLG IQMLWTRDSE EALQNAKFDK
1860 1870 1880 1890 1900
KIMQKTNQSF LELLNMLIEM TTKDLSSMER VKYETLITIH VHQRDIFDDL
1910 1920 1930 1940 1950
CHMHVKSPTD FEWLKQCRFY FKEDSDKTMI HITDVAFTYQ NEFLGCTDRL
1960 1970 1980 1990 2000
VITPLTDRCY ITLAQALGMS MGGAPAGPAG TGKTETTKDM GRCLGKYVVV
2010 2020 2030 2040 2050
FNCSDQMDFR GLGRIFKGLA QSGSWGCFDE FNRIDLPVLS VAAQQISIIL
2060 2070 2080 2090 2100
TCKKEHKKSF IFTDGDNVTM NPEFGLFLTM NPGYAGRQEL PENLKINFRS
2110 2120 2130 2140 2150
VAMMVPDRQI IIRVKLASCG FIDNVVLARK FFTLYQLCEE QLSKQVHYDF
2160 2170 2180 2190 2200
GLRNILSVLR TLGAAKRASH TDTESTIVMR VLRDMNLSKL IDEDEPLFLS
2210 2220 2230 2240 2250
LIEDLFPNIL LDKAGYPELE TAISKQVEEA GLINHPPWKL KVIQLFETQR
2260 2270 2280 2290 2300
VRHGMMTLGP SGSGKTSCIH TLMKAMTDCG KPHREMRMNP KAITAPQMFG
2310 2320 2330 2340 2350
RLDVATNDWT DGIFSTLWRK TLKAKKGEHI WIVLDGPVDA IWIENLNSVL
2360 2370 2380 2390 2400
DDNKTLTLAN GDRIPMAPNC KIVFEPHNID NASPATVSRN GMVFMSSSVL
2410 2420 2430 2440 2450
DWSPILEGFL KRRSPQEAEI LRQLYAETFP DLYRFSIQNL EFKMEILEAF
2460 2470 2480 2490 2500
VITQSTHMLQ GLIPTKEQAG DVDPEHLGRL FVFAMMWSVG AVLELEGRRR
2510 2520 2530 2540 2550
MELWLRSREG PTLHLPQLTD PGDTMFDYYV APDGTWRHWS MCIPEYVYPP
2560 2570 2580 2590 2600
DTTPEYGSIL VPNVDNVRTD FLIKTIAKQG KAVLLIGEQG TAKTVIIKGF
2610 2620 2630 2640 2650
MSKFDPESHT VKNLNFSSAT TPLMFQRTIE SYVDKRMGTT YGPPAGKKMA
2660 2670 2680 2690 2700
VFIDDLNMPV INEWGDQVTN EIVRQLMEQN GFYNLEKPGE FTSIVDIQFL
2710 2720 2730 2740 2750
AAMIHPGGGR NDIPQRLKRQ FSIFNCTLPS DASMDKIFGV IGEGYYCAQR
2760 2770 2780 2790 2800
GFSKEVQDAV IKLVPLTRRL WQMTKLKMLP TPAKFHYVFN LRDLSRIWQG
2810 2820 2830 2840 2850
MLNITSEVIK DTDELLRLWK HECKRVIADR FSMSSDVTWF DKAVVSLVEE
2860 2870 2880 2890 2900
EFGEEKTPVV DCGVDAYFVD FLRDAPEATG ETPEETDAEM PKLYEPIASL
2910 2920 2930 2940 2950
NHLQERLSVF LQLYNESIRG TGMDMVFFRD AMVHLVKISR VIRTPRGNAL
2960 2970 2980 2990 3000
LVGVGGSGKQ SLTRLASFIA GYTSFQITLT RSYNTSNLME DLKVLYRTAG
3010 3020 3030 3040 3050
QQGKGITFIF TDNEIKEESF LEYMNNVLSS GEVSNLFARD EIDEINSDLT
3060 3070 3080 3090 3100
SIMKKEHPKR PPTNDNLYEY FMSRVRGNLH IVLCFSPVGE KFRNRALKFP
3110 3120 3130 3140 3150
ALISGCTIDW FSRWPKDALV AVSEHFLSSY NIDCTAEIKK ELVQCMGSFQ
3160 3170 3180 3190 3200
DGVAEKCADY FQRFRRSTHV TPKSYLSFIQ GYKFIYEEKH VEVQSLANRM
3210 3220 3230 3240 3250
NTGLEKLKEA SESVAALSQE LAVKEKELQV ANEKADMVLK EVTMKAQAAE
3260 3270 3280 3290 3300
KVKAEVQKVK DKAQAIVDSI SKDKAIAEEK LEAAKPALEE AEAALQTIKP
3310 3320 3330 3340 3350
SDIATVRTLG RPPHLIMRIM DCVLLLFHRR VNAVKIDLDK SCTVPSWQES
3360 3370 3380 3390 3400
LKLMTAGNFL QNLQQFPKDT INEEVIEFLS PYFEMSDYNI ETAKRVCGNV
3410 3420 3430 3440 3450
AGLCSWTKAM ASFFSINKEV LPLKANLIVQ ENRHALAMQD LQKAQAELDD
3460 3470
KQAELDVVQA EYEQAMTEKQ
Length:3,470
Mass (Da):395,933
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC2B495A5A3F7BC6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AABR07008948 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei34701

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07008948 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000074689; ENSRNOP00000065896; ENSRNOG00000048363

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008948 Genomic DNA No translation available.

3D structure databases

SMRiM0R8U1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065896

Proteomic databases

PaxDbiM0R8U1
PRIDEiM0R8U1

Genome annotation databases

EnsembliENSRNOT00000074689; ENSRNOP00000065896; ENSRNOG00000048363

Organism-specific databases

RGDi1560828, Dnah5

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000155533
HOGENOMiCLU_000038_9_1_1
InParanoidiM0R8U1
OMAiFQKRDRY

Gene expression databases

BgeeiENSRNOG00000048363, Expressed in heart and 7 other tissues

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF17857, AAA_lid_1, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 3 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M0R8U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: April 3, 2013
Last modified: August 12, 2020
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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