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Entry version 54 (02 Jun 2021)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

ATP-binding cassette, subfamily A (ABC1), member 14

Gene

Abca14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi555 – 562ATPPROSITE-ProRule annotation8
Nucleotide bindingi1391 – 1398ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette, subfamily A (ABC1), member 14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1561491, Abca14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei249 – 278HelicalSequence analysisAdd BLAST30
Transmembranei298 – 325HelicalSequence analysisAdd BLAST28
Transmembranei337 – 360HelicalSequence analysisAdd BLAST24
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei440 – 463HelicalSequence analysisAdd BLAST24
Transmembranei1072 – 1092HelicalSequence analysisAdd BLAST21
Transmembranei1113 – 1138HelicalSequence analysisAdd BLAST26
Transmembranei1150 – 1174HelicalSequence analysisAdd BLAST25
Transmembranei1181 – 1203HelicalSequence analysisAdd BLAST23
Transmembranei1215 – 1234HelicalSequence analysisAdd BLAST20
Transmembranei1279 – 1295HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
M0R7Y5

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
M0R7Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000043296, Expressed in testis and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M0R7Y5, baseline

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M0R7Y5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini519 – 752ABC transporterInterPro annotationAdd BLAST234
Domaini1359 – 1589ABC transporterInterPro annotationAdd BLAST231

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164007

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M0R7Y5

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFYIRER

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M0R7Y5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSLLMRQFL VLLWKNFLLK SRKVFGLVVE IILIFLLFVW TLTVRRISKK
60 70 80 90 100
KFIPAMIFNP IPLTLPGFLN QNFDYELAYV PSDSNAARNI TEMVKKDLNF
110 120 130 140 150
NFKVQGFSSE ESFEYIKYED KGHSLFASVV SRSWFSTSVS KVRLKVKYSL
160 170 180 190 200
RFGRMYDPEN VLKPSERQKE TEWNTSILFP SVPSLGPRNV LENDGGNPGY
210 220 230 240 250
IREGFLLVQH SVDKAIMMHH SGRAAEAMFA NTTIYARRFP YPAFIHDNFL
260 270 280 290 300
WTFIVMFPWT ILFTFTQMAL DIIGTIMLEK EKRLKEYQLM VGLSNAMLWV
310 320 330 340 350
SYFITFLLMY FIIICLLCGI LFLKITHERV FQHSDPLFIA FYFLCFAISS
360 370 380 390 400
MLLGFMISTF FNRASLATSI AGFLHFLTFF PYLIVFSLYD QTSLSGKLAL
410 420 430 440 450
CLITNTALAF GTDLICKLEM KGHGAQWYNF ATKVNPDDDL TLAHIIGMFL
460 470 480 490 500
FSAFLYGLVA WYVDAVFPGK YGVPKPWNFF LQKTYWFGEP ALSREESQVS
510 520 530 540 550
DLPPSDFMEP EPVDLEAGIQ IQHLYKEFTL KNSTLMAVKD LSLNLYEGQI
560 570 580 590 600
TVLLGHNGAG KTTTLSILTG LYLPTKGKVY ISGYDISSDM VQVRKSLGLC
610 620 630 640 650
PQDDLLFPLL TVSEHLYFYC VIKGISSTNR PREIHRMLTS FGLLQKSNTM
660 670 680 690 700
SKDLSGGMKR KLSIIIALIG DTKVVILDEP TSGMDPVSRR AIWDLLQHYK
710 720 730 740 750
KDRTILLTTH HMDEADVLGD RIAILVMGVL KCCGSSLFLK KLYGVGYHLV
760 770 780 790 800
IVKTPDSDDG KISQLIKNYI PTAEMETNVA AELSFILPKE HTHRFAELFT
810 820 830 840 850
DLEERQEELG ISGFGVSMTT MDEVFFKVSN LADLKLNTEI AQSASTVNPS
860 870 880 890 900
TSENNENMNV PRNFERSGYS GRYSDSSFNA GWPLYMQQFR AMFIKRVMFS
910 920 930 940 950
WRNWKLLLLQ LLALQGLTYV LIKGIGFSVP KEPARVMDLE QYGETTVPFS
960 970 980 990 1000
VSGDPPLTQK LTKNLEIMLK DKKQKVHEVQ GGVQDYLLTN KDCIYSCIVA
1010 1020 1030 1040 1050
FSLDVTRKEK TFTFWFNNEA YHASPLSLSI LDNIIFKYLS GPDATITVSN
1060 1070 1080 1090 1100
KPQPQPFTKG RSEERSASGI QIVFNLLFGM SIFTSGFCLM TVTERVSKAK
1110 1120 1130 1140 1150
HIQFVSGVYT LNFWLSALLW DLIIHFVACV LLLLVFLYTD VHILLENYNF
1160 1170 1180 1190 1200
LDTMLILMLF GWSIIPFIYL LSFWYNNSTN AYIKIFVFNH CLGFMSIIVD
1210 1220 1230 1240 1250
AVVELIPDIK TSTKNLILNS LLLLPIYNFG MSIFKYYSIQ EIRKLCSSLG
1260 1270 1280 1290 1300
SLNTFSGCQH EPYSVTVYSM DKRAIGRHVT AMAATGLIYF LFIILLETTS
1310 1320 1330 1340 1350
WNLKAFIYRY VLFGIYKIFY KARMSKELSG DSEDEDVQNE RETILQHSWH
1360 1370 1380 1390 1400
SLNSTVLIKK LIKIYFKIPP TLAVRNISLT IQKEECFGLL GLNGAGKTTT
1410 1420 1430 1440 1450
FKILTGEEIA TSGDVFIEGY SITRNILKVR SKIGYCPQFD ALLDYMTSRE
1460 1470 1480 1490 1500
ILTMYARVWG IPENNIRSYV NNLLKMLYLK PQAEKFIYTL SGGNKRRLST
1510 1520 1530 1540 1550
AIAIMGNSSV VFLDEPSTGM DPLARRMLWN AVIRTRESGK VIIITSHSME
1560 1570 1580 1590 1600
ECEALCTRLA IMVQGKLVCL GSPQHLKNKF GNIYTMNIKF KTGTDDDVVQ
1610 1620 1630 1640 1650
DLKNYIAEVF PGSDLKQENQ GILNYYIPSK DNSWGKVFGI LEKAKEDYNL
1660 1670 1680
EDYSISQITL EQVFLTFANP DNTESGYEKA VP
Length:1,682
Mass (Da):191,680
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF03C346C8BFC3618
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M2Q5F1M2Q5_RAT
ATP-binding cassette, subfamily A (...
Abca14
1,680Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0RDE2M0RDE2_RAT
ATP-binding cassette, subfamily A (...
Abca14
782Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07005599 Genomic DNA No translation available.
AABR07005600 Genomic DNA No translation available.
AABR07005601 Genomic DNA No translation available.
AABR07005602 Genomic DNA No translation available.
AABR07005603 Genomic DNA No translation available.
AABR07005604 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000071302; ENSRNOP00000065573; ENSRNOG00000043296

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005599 Genomic DNA No translation available.
AABR07005600 Genomic DNA No translation available.
AABR07005601 Genomic DNA No translation available.
AABR07005602 Genomic DNA No translation available.
AABR07005603 Genomic DNA No translation available.
AABR07005604 Genomic DNA No translation available.

3D structure databases

SMRiM0R7Y5
ModBaseiSearch...

PTM databases

PhosphoSitePlusiM0R7Y5

Proteomic databases

PRIDEiM0R7Y5

Genome annotation databases

EnsembliENSRNOT00000071302; ENSRNOP00000065573; ENSRNOG00000043296

Organism-specific databases

RGDi1561491, Abca14

Phylogenomic databases

GeneTreeiENSGT00940000164007
HOGENOMiCLU_000604_19_1_1
InParanoidiM0R7Y5
OMAiIFYIRER

Gene expression databases

BgeeiENSRNOG00000043296, Expressed in testis and 4 other tissues
ExpressionAtlasiM0R7Y5, baseline

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM0R7Y5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M0R7Y5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: July 22, 2015
Last modified: June 2, 2021
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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