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UniProtKB - M0R4V9 (M0R4V9_RAT)
Protein
Submitted name:
Nuclear receptor subfamily 2, group E, member 1
Gene
Nr2e1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- aggressive behavior Source: RGD
- amygdala development Source: RGD
- anatomical structure development Source: GO_Central
- anterior commissure morphogenesis Source: RGD
- behavioral fear response Source: RGD
- brain development Source: RGD
- camera-type eye development Source: RGD
- cell differentiation Source: GO_Central
- cell fate commitment Source: RGD
- cerebral cortex development Source: RGD
- cerebral cortex neuron differentiation Source: RGD
- dentate gyrus development Source: RGD
- extracellular matrix organization Source: RGD
- forebrain generation of neurons Source: RGD
- glial cell migration Source: RGD
- layer formation in cerebral cortex Source: RGD
- long-term synaptic potentiation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of astrocyte differentiation Source: RGD
- negative regulation of neural precursor cell proliferation Source: RGD
- negative regulation of neuron differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- olfactory bulb development Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of cell cycle Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of neural precursor cell proliferation Source: RGD
- positive regulation of stem cell proliferation Source: RGD
- regulation of cell migration involved in sprouting angiogenesis Source: RGD
- regulation of cellular component organization Source: RGD
- regulation of dendrite morphogenesis Source: RGD
- regulation of timing of neuron differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- retina development in camera-type eye Source: RGD
- social behavior Source: RGD
- somatic stem cell population maintenance Source: RGD
- visual perception Source: RGD
Keywordsi
Molecular function | DNA-bindingUniRule annotation, ReceptorUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear receptor subfamily 2, group E, member 1 |
Gene namesi | Name:Nr2e1Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1595162, Nr2e1 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000050550, Expressed in frontal cortex and 4 other tissues |
Interactioni
GO - Molecular functioni
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000064408 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156693 |
HOGENOMi | CLU_007368_20_3_1 |
OMAi | VVSLMHK |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
M0R4V9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKSGRILDI PCKVCGDRSS GKHYGVYACD GCSGFFKRSI RRNRTYVCKS
60 70 80 90 100
GNQGGCPVDK THRNQCRACR LKKCLEVNMN KDAVQHERGP RTSTIRKQVA
110 120 130 140 150
LYFRGHKEDN GAAAHFPSAA LPAPAFFTAV TQLEPHGLEL TAVSATPERQ
160 170 180 190 200
TLVSLAQPTP KYPHEVNGTP MYLYEVATES VCESAARLLF MSIKWAKSVP
210 220 230 240 250
AFSTLSLQDQ LMLLEDAWRE LFVLGIAQWA IPVDANTLLA VSGMNSDNTD
260 270 280 290 300
SQKLNKIISE IQALQEVVAR FRQLRLDATE FACLKCIVTF KAVPTHSGSE
310 320 330 340 350
LRSFRNAAAI AALQDEAQLT LNSYIHTRYP TQPCRFGKLL LLLPALRSIS
360 370 380
PSTIEEVFFK KTIGNVPITR LLSDMYKSSD I
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5ZSJ5 | A0A8I5ZSJ5_RAT | Nuclear receptor subfamily 2, group... | Nr2e1 rCG_58537 | 385 | Annotation score: | ||
A0A8I6AJN9 | A0A8I6AJN9_RAT | Nuclear receptor subfamily 2, group... | Nr2e1 | 173 | Annotation score: |
Genome annotation databases
Ensembli | ENSRNOT00000075151.2; ENSRNOP00000064408.2; ENSRNOG00000050550.2 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000064408 |
Genome annotation databases
Ensembli | ENSRNOT00000075151.2; ENSRNOP00000064408.2; ENSRNOG00000050550.2 |
Organism-specific databases
RGDi | 1595162, Nr2e1 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156693 |
HOGENOMi | CLU_007368_20_3_1 |
OMAi | VVSLMHK |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway |
Gene expression databases
Bgeei | ENSRNOG00000050550, Expressed in frontal cortex and 4 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M0R4V9_RAT | |
Accessioni | M0R4V9Primary (citable) accession number: M0R4V9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 67 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |