Nr2e1

Functionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
sequence-specific DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aggressive behavior Source: Ensembl
amygdala development Source: Ensembl
anterior commissure morphogenesis Source: Ensembl
behavioral fear response Source: Ensembl
cell fate commitment Source: Ensembl
cerebral cortex neuron differentiation Source: Ensembl
dentate gyrus development Source: Ensembl
extracellular matrix organization Source: Ensembl
forebrain generation of neurons Source: Ensembl
layer formation in cerebral cortex Source: Ensembl
long-term synaptic potentiation Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of astrocyte differentiation Source: Ensembl
negative regulation of neural precursor cell proliferation Source: Ensembl
negative regulation of neuron differentiation Source: Ensembl
olfactory bulb development Source: Ensembl
positive regulation of angiogenesis Source: Ensembl
positive regulation of cell cycle Source: Ensembl
positive regulation of neural precursor cell proliferation Source: Ensembl
positive regulation of stem cell proliferation Source: Ensembl
regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
regulation of dendrite morphogenesis Source: Ensembl
regulation of timing of neuron differentiation Source: Ensembl
retina development in camera-type eye Source: Ensembl
social behavior Source: Ensembl
somatic stem cell population maintenance Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule
visual perception Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Nuclear receptor subfamily 2, group E, member 1Imported Submitted name: RCG58537Imported
Gene namesⁱ	Name:Nr2e1Imported ORF Names:rCG_58537Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 20

Organism-specific databases

Rat genome database More...RGDⁱ	1595162 Nr2e1

RGDⁱ

1595162 Nr2e1

Keywords - Cellular componentⁱ

NucleusUniRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	M0R4V9

PRIDEⁱ

M0R4V9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000050550 Expressed in 2 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000050550 Expressed in 2 organ(s), highest expression level in brain

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000064408

STRINGⁱ

10116.ENSRNOP00000064408

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 90	Nuclear receptorInterPro annotationAdd BLAST		78
Domainⁱ	155 – 383	NR LBDInterPro annotationAdd BLAST		229

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	258 – 278	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118948
OMAⁱ	FPGVPMP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AV3

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

M0R4V9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY 
        60         70         80         90        100
VCKSGNQGGC PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR 
       110        120        130        140        150
KQVALYFRGH KEDNGAAAHF PSAALPAPAF FTAVTQLEPH GLELTAVSAT 
       160        170        180        190        200
PERQTLVSLA QPTPKYPHEV NGTPMYLYEV ATESVCESAA RLLFMSIKWA 
       210        220        230        240        250
KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAN TLLAVSGMNS 
       260        270        280        290        300
DNTDSQKLNK IISEIQALQE VVARFRQLRL DATEFACLKC IVTFKAVPTH 
       310        320        330        340        350
SGSELRSFRN AAAIAALQDE AQLTLNSYIH TRYPTQPCRF GKLLLLLPAL 
       360        370        380 
RSISPSTIEE VFFKKTIGNV PITRLLSDMY KSSDI

Length:385

Mass (Da):42,605

Last modified:April 3, 2013 - v1

Checksum:ⁱF4639E5803304DDF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07045433 Genomic DNA No translation available. AABR07045434 Genomic DNA No translation available. CH474025 Genomic DNA Translation: EDL99704.1
UniGeneⁱ	Rn.218964

Genome annotation databases

Ensemblⁱ	ENSRNOT00000075151; ENSRNOP00000064408; ENSRNOG00000050550

Ensemblⁱ

ENSRNOT00000075151; ENSRNOP00000064408; ENSRNOG00000050550

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
M0R4V9	Nuclear receptor subfamily 2 group E member 1		MOUSE		385	UniRef90_Q64104
Nuclear receptor subfamily 2 group E member 1		XENLA		386
Nuclear receptor subfamily 2 group E member 1		CHICK		385
Nuclear receptor subfamily 2 group E member 1	)	HUMAN		385
Uncharacterized protein		RABIT		475
+130

Protein	Similar proteins		Species	Score	Length	Source
M0R4V9	Nuclear receptor subfamily 2 group E member 1		MOUSE		385	UniRef50_Q64104
Nuclear receptor subfamily 2 group E member 1		XENLA		386
Nuclear receptor subfamily 2 group E member 1	)	HUMAN		385
Nuclear receptor subfamily 2 group E member 1		CHICK		385
Nuclear receptor subfamily 2 group E member 1		ORYLA		396
+267

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07045433 Genomic DNA No translation available. AABR07045434 Genomic DNA No translation available. CH474025 Genomic DNA Translation: EDL99704.1
UniGeneⁱ	Rn.218964

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000064408

STRINGⁱ

10116.ENSRNOP00000064408

Proteomic databases

PRIDEⁱ	M0R4V9

PRIDEⁱ

M0R4V9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000075151; ENSRNOP00000064408; ENSRNOG00000050550

Ensemblⁱ

ENSRNOT00000075151; ENSRNOP00000064408; ENSRNOG00000050550

Organism-specific databases

RGDⁱ	1595162 Nr2e1

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118948
OMAⁱ	FPGVPMP
OrthoDBⁱ	EOG091G0AV3

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway

Gene expression databases

Bgeeⁱ	ENSRNOG00000050550 Expressed in 2 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000050550 Expressed in 2 organ(s), highest expression level in brain

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M0R4V9_RAT
Accessionⁱ	M0R4V9Primary (citable) accession number: M0R4V9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 3, 2013
	Last sequence update:	April 3, 2013
	Last modified:	November 7, 2018
	This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - M0R4V9 (M0R4V9_RAT)

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Nuclear receptor subfamily 2, group E, member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ