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Entry version 52 (07 Oct 2020)
Sequence version 1 (03 Apr 2013)
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Protein
Submitted name:

Neurogenic locus notch homolog protein 3

Gene

NOTCH3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neurogenic locus notch homolog protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000074181.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7883, NOTCH3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000074181

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500400416739 – 1286Sequence analysisAdd BLAST1248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi66 ↔ 75PROSITE-ProRule annotation
Disulfide bondi107 ↔ 116PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi223 ↔ 232PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi339 ↔ 348PROSITE-ProRule annotation
Disulfide bondi359 ↔ 376PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi494 ↔ 503PROSITE-ProRule annotation
Disulfide bondi532 ↔ 541PROSITE-ProRule annotation
Disulfide bondi548 ↔ 558PROSITE-ProRule annotation
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
Disulfide bondi623 ↔ 633PROSITE-ProRule annotation
Disulfide bondi644 ↔ 653PROSITE-ProRule annotation
Disulfide bondi682 ↔ 691PROSITE-ProRule annotation
Disulfide bondi698 ↔ 708PROSITE-ProRule annotation
Disulfide bondi719 ↔ 728PROSITE-ProRule annotation
Disulfide bondi759 ↔ 768PROSITE-ProRule annotation
Disulfide bondi822 ↔ 831PROSITE-ProRule annotation
Disulfide bondi838 ↔ 848PROSITE-ProRule annotation
Disulfide bondi859 ↔ 868PROSITE-ProRule annotation
Disulfide bondi897 ↔ 906PROSITE-ProRule annotation
Disulfide bondi935 ↔ 944PROSITE-ProRule annotation
Disulfide bondi971 ↔ 980PROSITE-ProRule annotation
Disulfide bondi1019 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi1057 ↔ 1066PROSITE-ProRule annotation
Disulfide bondi1095 ↔ 1104PROSITE-ProRule annotation
Disulfide bondi1140 ↔ 1149PROSITE-ProRule annotation
Disulfide bondi1181 ↔ 1190PROSITE-ProRule annotation
Disulfide bondi1224 ↔ 1233PROSITE-ProRule annotation
Disulfide bondi1262 ↔ 1271PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
M0R3C9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074181, Expressed in vagina and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M0R3C9, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 76EGF-likeInterPro annotationAdd BLAST39
Domaini77 – 117EGF-likeInterPro annotationAdd BLAST41
Domaini118 – 155EGF-likeInterPro annotationAdd BLAST38
Domaini157 – 194EGF-likeInterPro annotationAdd BLAST38
Domaini196 – 233EGF-likeInterPro annotationAdd BLAST38
Domaini235 – 271EGF-likeInterPro annotationAdd BLAST37
Domaini273 – 311EGF-likeInterPro annotationAdd BLAST39
Domaini313 – 349EGF-likeInterPro annotationAdd BLAST37
Domaini350 – 388EGF-likeInterPro annotationAdd BLAST39
Domaini390 – 428EGF-likeInterPro annotationAdd BLAST39
Domaini430 – 466EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 504EGF-likeInterPro annotationAdd BLAST37
Domaini506 – 542EGF-likeInterPro annotationAdd BLAST37
Domaini544 – 579EGF-likeInterPro annotationAdd BLAST36
Domaini581 – 617EGF-likeInterPro annotationAdd BLAST37
Domaini619 – 654EGF-likeInterPro annotationAdd BLAST36
Domaini656 – 692EGF-likeInterPro annotationAdd BLAST37
Domaini694 – 729EGF-likeInterPro annotationAdd BLAST36
Domaini733 – 769EGF-likeInterPro annotationAdd BLAST37
Domaini793 – 832EGF-likeInterPro annotationAdd BLAST40
Domaini834 – 869EGF-likeInterPro annotationAdd BLAST36
Domaini871 – 907EGF-likeInterPro annotationAdd BLAST37
Domaini909 – 945EGF-likeInterPro annotationAdd BLAST37
Domaini947 – 981EGF-likeInterPro annotationAdd BLAST35
Domaini993 – 1029EGF-likeInterPro annotationAdd BLAST37
Domaini1031 – 1067EGF-likeInterPro annotationAdd BLAST37
Domaini1069 – 1105EGF-likeInterPro annotationAdd BLAST37
Domaini1107 – 1150EGF-likeInterPro annotationAdd BLAST44
Domaini1152 – 1191EGF-likeInterPro annotationAdd BLAST40
Domaini1193 – 1234EGF-likeInterPro annotationAdd BLAST42
Domaini1236 – 1272EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160234

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003672_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 18 hits
PF07645, EGF_CA, 5 hits
PF12661, hEGF, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 32 hits
SM00179, EGF_CA, 28 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 17 hits
PS00022, EGF_1, 30 hits
PS01186, EGF_2, 22 hits
PS50026, EGF_3, 31 hits
PS01187, EGF_CA, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

M0R3C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GPGARGRRRR RRPMSPPPPP PPVRALPLLL LLAGPGAAAP PCLDGSPCAN
60 70 80 90 100
GGRCTQLPSR EAACLCPPGW VGERCQLEDP CHSGPCAGRG VCQSSVVAGT
110 120 130 140 150
ARFSCRCPRG FRGPDCSLPD PCLSSPCAHG ARCSVGPDGR FLCSCPPGYQ
160 170 180 190 200
GRSCRSDVDE CRVGEPCRHG GTCLNTPGSF RCQCPAGYTG PLCENPAVPC
210 220 230 240 250
APSPCRNGGT CRQSGDLTYD CACLPGFEGQ NCEVNVDDCP GHRCLNGGTC
260 270 280 290 300
VDGVNTYNCQ CPPEWTGQFC TEDVDECQLQ PNACHNGGTC FNTLGGHSCV
310 320 330 340 350
CVNGWTGESC SQNIDDCATA VCFHGATCHD RVASFYCACP MGKTGLLCHL
360 370 380 390 400
DDACVSNPCH EDAICDTNPV NGRAICTCPP GFTGGACDQD VDECSIGANP
410 420 430 440 450
CEHLGRCVNT QGSFLCQCGR GYTGPRCETD VNECLSGPCR NQATCLDRIG
460 470 480 490 500
QFTCICMAGF TGTYCEVDID ECQSSPCVNG GVCKDRVNGF SCTCPSGFSG
510 520 530 540 550
STCQLDVDEC ASTPCRNGAK CVDQPDGYEC RCAEGFEGTL CDRNVDDCSP
560 570 580 590 600
DPCHHGRCVD GIASFSCACA PGYTGTRCES QVDECRSQPC RHGGKCLDLV
610 620 630 640 650
DKYLCRCPSG TTGVNCEVNI DDCASNPCTF GVCRDGINRY DCVCQPGFTG
660 670 680 690 700
PLCNVEINEC ASSPCGEGGS CVDGENGFRC LCPPGSLPPL CLPPSHPCAH
710 720 730 740 750
EPCSHGICYD APGGFRCVCE PGWSGPRCSQ SLARDACESQ PCRAGGTCSS
760 770 780 790 800
DGMGFHCTCP PGVQGRQCEL LSPCTPNPCE HGGRCESAPG QLPVCSCPQG
810 820 830 840 850
WQDPCLNGGS CQDGVGSFSC SCLPGFAGPR CARDVDECLS NPCGPGTCTD
860 870 880 890 900
HVASFTCTCP PGYGGFHCEQ DLPDCSPSSC FNGGTCVDGV NSFSCLCRPG
910 920 930 940 950
YTGAHCQHEA DPCLSRPCLH GGVCSAAHPG FRCTCLESFT GPQCQTLVDW
960 970 980 990 1000
CSRQPCQNGG RCVQTGAYCL CPPGWSGRLC DIRSLPCREA AAQIGVRLEQ
1010 1020 1030 1040 1050
LCQAGGQCVD EDSSHYCVCP EGRTGSHCEQ EVDPCLAQPC QHGGTCRGYM
1060 1070 1080 1090 1100
GGYMCECLPG YNGDNCEDDV DECASQPCQH GGSCIDLVAR YLCSCPPGTL
1110 1120 1130 1140 1150
GVLCEINEDD CGPGPPLDSG PRCLHNGTCV DLVGGFRCTC PPGYTGLRCE
1160 1170 1180 1190 1200
ADINECRSGA CHAAHTRDCL QDPGGGFRCL CHAGFSGPRC QTVLSPCESQ
1210 1220 1230 1240 1250
PCQHGGQCRP SPGPGGGLTF TCHCAQPFWG PRCERVARSC RELQCPVGVP
1260 1270 1280
CQQTPRGPRC ACPPGLSGPS CRSFPGSPPG ASNASC
Length:1,286
Mass (Da):134,318
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA43C93C04502FACF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UM47NOTC3_HUMAN
Neurogenic locus notch homolog prot...
NOTCH3
2,321Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX38M0QX38_HUMAN
Neurogenic locus notch homolog prot...
NOTCH3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZN3M0QZN3_HUMAN
Neurogenic locus notch homolog prot...
NOTCH3
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1286Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004257 Genomic DNA No translation available.
AC004663 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000601011; ENSP00000473138; ENSG00000074181

UCSC genome browser

More...
UCSCi
uc060usd.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004257 Genomic DNA No translation available.
AC004663 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiM0R3C9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3951, 677 antibodies

Genome annotation databases

EnsembliENST00000601011; ENSP00000473138; ENSG00000074181
UCSCiuc060usd.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000074181.8
HGNCiHGNC:7883, NOTCH3
OpenTargetsiENSG00000074181

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000160234
HOGENOMiCLU_003672_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOTCH3, human

Gene expression databases

BgeeiENSG00000074181, Expressed in vagina and 231 other tissues
ExpressionAtlasiM0R3C9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008, EGF, 18 hits
PF07645, EGF_CA, 5 hits
PF12661, hEGF, 4 hits
SMARTiView protein in SMART
SM00181, EGF, 32 hits
SM00179, EGF_CA, 28 hits
SUPFAMiSSF57184, SSF57184, 5 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 17 hits
PS00022, EGF_1, 30 hits
PS01186, EGF_2, 22 hits
PS50026, EGF_3, 31 hits
PS01187, EGF_CA, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM0R3C9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M0R3C9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: October 7, 2020
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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