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Entry version 43 (31 Jul 2019)
Sequence version 1 (03 Apr 2013)
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Protein

Doublecortin domain-containing protein 1

Gene

DCDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • microtubule binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • intracellular signal transduction Source: InterPro
  • regulation of mitotic cytokinesis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Doublecortin domain-containing protein 1Curated
Alternative name(s):
Doublecortin domain-containing 5 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCDC1Imported
Synonyms:DCDC51 Publication, KIAA1493
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20625 DCDC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608062 gene

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
341019

Open Targets

More...
OpenTargetsi
ENSG00000170959

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134970075

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCDC1
HGNC:24799

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160332323
190359182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004460881 – 1783Doublecortin domain-containing protein 1Add BLAST1783

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59894

PeptideAtlas

More...
PeptideAtlasi
M0R2J8

PRoteomics IDEntifications database

More...
PRIDEi
M0R2J8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57166
6281
68160

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
M0R2J8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170959 Expressed in 89 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M0R2J8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with dynein intermediate chain, tubulin, RAB8A, RAB3IP, NUDC, PAFAH1B1 and DCTN1 (PubMed:22159412).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131112, 1 interactor

Protein interaction database and analysis system

More...
IntActi
M0R2J8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385936

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M0R2J8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 252Doublecortin 1PROSITE-ProRule annotationAdd BLAST85
Domaini702 – 800Ricin B-type lectin 1PROSITE-ProRule annotationAdd BLAST99
Domaini925 – 1015Doublecortin 2PROSITE-ProRule annotationAdd BLAST91
Domaini1151 – 1266Ricin B-type lectin 2PROSITE-ProRule annotationAdd BLAST116

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDIP Eukaryota
ENOG41122B9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000078278

KEGG Orthology (KO)

More...
KOi
K23400

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPIEGLL

TreeFam database of animal gene trees

More...
TreeFami
TF329467

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00161 RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00537 DCX, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370 SSF50370, 2 hits
SSF89837 SSF89837, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50309 DC, 2 hits
PS50231 RICIN_B_LECTIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: M0R2J8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL
60 70 80 90 100
NDLPREFMSS QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH
110 120 130 140 150
QTASDHSHDE ISDLDSYKSN SKNNSCSISA SKRNRPVSAP VGQLRVAEFS
160 170 180 190 200
SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK NGSRTVFARV TVPTITLLLE
210 220 230 240 250
ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG EPFLNPFKKI
260 270 280 290 300
KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF
310 320 330 340 350
KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS
360 370 380 390 400
KVPLLEKCLQ NSITPLRGLL WVSKGEGFSP SGAKMYIQGV LLALYQRLKS
410 420 430 440 450
AKKYYKQLNL VMNEQKEKIT EKVILSMTAK EHHKEQEEVS RLIDELQTAI
460 470 480 490 500
KSNIGHLCKL GPQLQAEQEQ FSSYVYQHIK SLPANTLVPG GLQLKVFENG
510 520 530 540 550
KNTGEISVGI SKKDLGSDSP IQTDHMMERL LLKIHQRLQG SSINPPGLNY
560 570 580 590 600
SSMRLFDENG QEIKNPLSLK NEQKIWVSYG RAYRSPLNLA LGLTFDRVSA
610 620 630 640 650
FARGDIMVAY KTFLDPNAVL LPGCGNWEVC EGFPINFNCT SQQIPDQFEK
660 670 680 690 700
VDLENHFLQN KVDPNIVLHA SVSIGKWSFS GSEASSRSQI APSILWPVAS
710 720 730 740 750
VWLITKTGMI LSRAITQGCL AIGHPIRVKA AEGTSLEGYK LILQKRHSGD
760 770 780 790 800
DSQKWVFGTD GCIYSKAYPQ FVLTYLEELN AQVDVTQTEY HIHHGAWTTA
810 820 830 840 850
HQEHGRNLAE EVLQESASNL GLKQLPEPSD THLMPEGSLE ETGELTVALV
860 870 880 890 900
RKLEEKHPKA SAQRWAIKHE GTSKPGQWKH SRVENPLWNK LTYMWPVLPS
910 920 930 940 950
GQLNEEFDWP IQGLLVPSSP PMKKPICKTT EPYAPVRLRV LQNGEKNKNR
960 970 980 990 1000
SVTILGPDIS PGRKTQCTEI LNLPSAARRL YNEKGKEIFA LKDLQRDELV
1010 1020 1030 1040 1050
YVSCGELWIN PDLSIAQQKK QIFLRNLESD IAKIQIFCST HKIEALVLEV
1060 1070 1080 1090 1100
QSDIVSGSKL AVHKPVAIFG EEKQVTEPEE KQMQEDPLTT ENASSEILDS
1110 1120 1130 1140 1150
HVRAHLRMKA CHTLPRYAWQ ETSHDFDEDD SLPKKTEKGL FENVEPQKKH
1160 1170 1180 1190 1200
SCSPKHSKLH KHCHQQFEYR DGQIISHAAP QLVLGVQGPN LRSGMEVVLV
1210 1220 1230 1240 1250
EKKSDGSHQR WIHQEDSRTF HLVSNPDLVL AVSMTKTRNE VCGYPVIVQK
1260 1270 1280 1290 1300
YKPYNNGAAN QKWHYMKNIK ALVAFHSTAL DKEITSANYA GVCTSSVIKE
1310 1320 1330 1340 1350
ENIDQPGYCY LSPDGKRKTM LCLACGQSMR TEKGLKQLLP GVPFLCISGT
1360 1370 1380 1390 1400
KTQKPFLQGP FKVISVAEVD LSCDKAEKTL SYYQARLLSL RMKTCTQAAS
1410 1420 1430 1440 1450
HSGMAATHQK AVKIIAYKNG DGYRNGKLIV AGTFPMLLTE CTEQLGLARA
1460 1470 1480 1490 1500
ASKVYTKDGT PIFTLRDLVL WALDESFLQR DSEKQKQDAA PVGKEQIIVE
1510 1520 1530 1540 1550
KNPRMKVKNR LFAKSVTSDS LDGIDKSLLT LILRNPIAIW VSCGEPFLPP
1560 1570 1580 1590 1600
NALQKAEKLE KQNWLKKDRI LADLDTMRHK MRQLKGRRVA ACQPATMVPT
1610 1620 1630 1640 1650
KSPVQPVVVE GGWTEQTQQE IKLMELIRHT EAHLSEIQEM ESKINFPIAT
1660 1670 1680 1690 1700
KRIAVKPSNL YKQPNTKRVW IYLNGGRPED GTYAWGKTIS ELLQDCSSRL
1710 1720 1730 1740 1750
KMTHPARALY TPSGEPIQSW DDIERDMVIC VSMGHGFKTP KELKQLMEIR
1760 1770 1780
ANYARIRRQQ GPQATDIVVS PSTKLLSLAH LHN
Length:1,783
Mass (Da):200,591
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4EC8D37407E6A92
GO
Isoform 2 (identifier: M0R2J8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-270: DHLLLIKKVTWTMNGLMLP → GFRYLYNKNESKFTSQIFL
     271-1783: Missing.

Show »
Length:270
Mass (Da):30,149
Checksum:iEACDF63FAE8B4D19
GO
Isoform 3 (identifier: M0R2J8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-354: VPL → GKH
     355-1783: Missing.

Show »
Length:354
Mass (Da):39,859
Checksum:i4C30ED8D93F7FBEE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B6ZDN3B6ZDN3_HUMAN
Doublecortin domain-containing prot...
DCDC1
890Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C298H7C298_HUMAN
Doublecortin domain-containing prot...
DCDC1
818Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2Q8H0Y2Q8_HUMAN
Doublecortin domain-containing prot...
DCDC1
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC87240 differs from that shown. Contaminating sequence and several conflicts. Sequence of unknown origin in the N-terminal part of the CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192V → A in AAP75563 (PubMed:12820024).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0372847E → G. Corresponds to variant dbSNP:rs11031357Ensembl.1
Natural variantiVAR_03376783V → M. Corresponds to variant dbSNP:rs2761591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060022252 – 270DHLLL…GLMLP → GFRYLYNKNESKFTSQIFL in isoform 2. Add BLAST19
Alternative sequenceiVSP_060023271 – 1783Missing in isoform 2. Add BLAST1513
Alternative sequenceiVSP_060024352 – 354VPL → GKH in isoform 3. 3
Alternative sequenceiVSP_060025355 – 1783Missing in isoform 3. Add BLAST1429

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY247970 mRNA Translation: AAP75563.1
AK126066 mRNA Translation: BAC86423.2
AK128035 mRNA Translation: BAC87240.1 Sequence problems.
AL133296 Genomic DNA No translation available.
AL133349 Genomic DNA No translation available.
AL133376 Genomic DNA No translation available.
AL135932 Genomic DNA No translation available.
AL137160 Genomic DNA No translation available.
AL137804 Genomic DNA No translation available.
AL162614 Genomic DNA No translation available.
KF455358 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7872.1 [M0R2J8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_861523.2, NM_181807.3 [M0R2J8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342355; ENSP00000343496; ENSG00000170959 [M0R2J8-2]
ENST00000452803; ENSP00000389792; ENSG00000170959 [M0R2J8-3]
ENST00000597505; ENSP00000472625; ENSG00000170959 [M0R2J8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
341019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:341019

UCSC genome browser

More...
UCSCi
uc058aah.1 human [M0R2J8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247970 mRNA Translation: AAP75563.1
AK126066 mRNA Translation: BAC86423.2
AK128035 mRNA Translation: BAC87240.1 Sequence problems.
AL133296 Genomic DNA No translation available.
AL133349 Genomic DNA No translation available.
AL133376 Genomic DNA No translation available.
AL135932 Genomic DNA No translation available.
AL137160 Genomic DNA No translation available.
AL137804 Genomic DNA No translation available.
AL162614 Genomic DNA No translation available.
KF455358 Genomic DNA No translation available.
CCDSiCCDS7872.1 [M0R2J8-3]
RefSeqiNP_861523.2, NM_181807.3 [M0R2J8-3]

3D structure databases

SMRiM0R2J8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131112, 1 interactor
IntActiM0R2J8, 1 interactor
STRINGi9606.ENSP00000385936

PTM databases

iPTMnetiM0R2J8

Polymorphism and mutation databases

BioMutaiDCDC1
HGNC:24799
DMDMi160332323
190359182

Proteomic databases

PaxDbiP59894
PeptideAtlasiM0R2J8
PRIDEiM0R2J8
ProteomicsDBi57166
6281
68160

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
341019
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342355; ENSP00000343496; ENSG00000170959 [M0R2J8-2]
ENST00000452803; ENSP00000389792; ENSG00000170959 [M0R2J8-3]
ENST00000597505; ENSP00000472625; ENSG00000170959 [M0R2J8-1]
GeneIDi341019
KEGGihsa:341019
UCSCiuc058aah.1 human [M0R2J8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
341019
DisGeNETi341019

GeneCards: human genes, protein and diseases

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GeneCardsi
DCDC1
HGNCiHGNC:20625 DCDC1
MIMi608062 gene
OpenTargetsiENSG00000170959
PharmGKBiPA134970075

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KDIP Eukaryota
ENOG41122B9 LUCA
GeneTreeiENSGT00940000163542
HOGENOMiHOG000078278
KOiK23400
OMAiWPIEGLL
TreeFamiTF329467

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DCDC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
341019

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170959 Expressed in 89 organ(s), highest expression level in right uterine tube
ExpressionAtlasiM0R2J8 baseline and differential

Family and domain databases

CDDicd00161 RICIN, 1 hit
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
SMARTiView protein in SMART
SM00537 DCX, 3 hits
SUPFAMiSSF50370 SSF50370, 2 hits
SSF89837 SSF89837, 5 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits
PS50231 RICIN_B_LECTIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCDC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M0R2J8
Secondary accession number(s): A6PVL6
, B1AL47, B7WNX6, P59894, Q6ZRR9, Q6ZU04
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2019
Last sequence update: April 3, 2013
Last modified: July 31, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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