UniProtKB - M0R2B7 (M0R2B7_HUMAN)
Protein
DNA polymerase
Gene
POLD1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)UniRule annotationARBA annotationEC:2.7.7.7UniRule annotationARBA annotation
Cofactori
[4Fe-4S] clusterUniRule annotationARBA annotation
GO - Molecular functioni
- 3'-5' exonuclease activity Source: Ensembl
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- enzyme binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- nucleotide binding Source: InterPro
GO - Biological processi
- base-excision repair, gap-filling Source: Ensembl
- DNA replication proofreading Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA replicationUniRule annotation |
Ligand | 4Fe-4SUniRule annotationARBA annotation, Iron, Iron-sulfur, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:POLD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000062822.12 |
HGNCi | HGNC:9175, POLD1 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Cytosol
- cytosol Source: HPA
Nucleus
- delta DNA polymerase complex Source: Ensembl
- nucleoplasm Source: HPA
Other locations
- aggresome Source: HPA
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000062822, Expressed in stomach and 192 other tissues |
ExpressionAtlasi | M0R2B7, baseline and differential |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
Protein-protein interaction databases
IntActi | M0R2B7, 1 interactor |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00560000077365 |
OMAi | GQQVKFI |
OrthoDBi | 20210at2759 |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_C IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf IPR025687, Znf-C4pol |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 2 hits PF03104, DNA_pol_B_exo1, 1 hit PF14260, zf-C4pol, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
M0R2B7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGKRRPGPG PGVPPKRARG GLWDDDDAPR PSQFEEDLAL MEEMEAEHRL
60 70 80 90 100
QEQEEEELQS VLEGVADGQV PPSAIDPRWL RPTPPALDPQ TEPLIFQQLE
110 120 130 140 150
IDHYVGPAQP VPGGPPPSRG SVPVLRAFGV TDEGFSVCCH IHGFAPYFYT
160 170 180 190 200
PAPPGFGPEH MGDLQRELNL AISRDSRGGR ELTGPAVLAV ELCSRESMFG
210 220 230 240 250
YHGHGPSPFL RITVALPRLV APARRLLEQG IRVAGLGTPS FAPYEANVDF
260 270 280 290 300
EIRFMVDTDI VGCNWLELPA GKYALRLKEK ATQCQLEADV LWSDVVSHPP
310 320 330 340 350
EGPWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF
360 370 380 390 400
LRLALTLRPC APILGAKVQS YEKEEDLLQA WSTFIRIMDP DVITGYNIQN
410 420 430 440 450
FDLPYLISRA QTLKVQTFPF LGRVAGLCSN IRDSSFQSKQ TGRRDTKVVS
460 470 480 490 500
MVGRVQMDML QVLLREYKLR SYTLNAVSFH FLGEQKEDVQ HSIITDLQNG
510 520 530 540 550
NDQTRRRLAV YCLKDAYLPL RLLERLMVLV NAVEMARVTG VPLSYLLSRG
560 570 580 590 600
QQVKVVSQLL RQAMHEGLLM PVVKSEGGED YTGATVIEPL KGVRPQDRAG
610 620 630 640 650
AAWELLALTP GRGCSPPRYY DVPIATLDFS SLYPSIMMAH NLCYTTLLRP
660 670 680 690 700
GTAQKLGLTE DQFIRTPTGD EFVKTSVRKG LLPQILENLL SARKRAKAEL
710 720 730 740 750
AKETDPLRRQ VLDGRQLALK VSANSVYGFT GAQVGKLPCL EISQSVTGFG
760 770 780 790 800
RQMIEKTKQL VESKYTVENG YSTSAKVVYG DTDSVMCRFG VSSVAEAMAL
810 820 830 840 850
GREAADWVSG HFPSPIRLEF EKVYFPYLLI SKKRYAGLLF SSRPDAHDRM
860 870 880 890 900
DCKGLEAVRR DNCPLVANLV TASLRRLLID RDPEGAVAHA QDVISDLLCN
910 920 930 940 950
RIDISQLVIT KELTRAASDY AGKQAHVELA ERMRKRDPGS APSLGDRVPY
960 970 980 990 1000
VIISAAKGVA AYMKSEDPLF VLEHSLPIDT QYYLEQQLAK PLLRIFEPIL
1010 1020 1030 1040 1050
GEGRAEAVLL RGDHTRCKTV LTGKVGGLLA FAKRRNCCIG CRTVLSHQGA
1060 1070 1080 1090 1100
VCEFCQPRES ELYQKEVSHL NALEERFSRL WTQCQRCQGS LHEDVICTSR
1110 1120 1130
DCPIFYMRKK VRKDLEDQEQ LLRRFGPPGP EAW
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP28340 | DPOD1_HUMAN | DNA polymerase delta catalytic subu... | POLD1 POLD | 1,107 | Annotation score: | ||
A0A087WYJ2 | A0A087WYJ2_HUMAN | DNA polymerase | POLD1 | 1,083 | Annotation score: | ||
M0QZR8 | M0QZR8_HUMAN | DNA polymerase | POLD1 | 1,009 | Annotation score: | ||
A0A2R8Y7K6 | A0A2R8Y7K6_HUMAN | DNA-directed DNA polymerase | POLD1 | 762 | Annotation score: | ||
A0A2R8Y705 | A0A2R8Y705_HUMAN | DNA polymerase | POLD1 | 447 | Annotation score: | ||
M0QXQ2 | M0QXQ2_HUMAN | DNA-directed DNA polymerase | POLD1 | 291 | Annotation score: | ||
M0QXE6 | M0QXE6_HUMAN | DNA-directed DNA polymerase | POLD1 | 289 | Annotation score: | ||
M0R2J2 | M0R2J2_HUMAN | DNA polymerase delta catalytic subu... | POLD1 | 105 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008655 Genomic DNA No translation available. AC020909 Genomic DNA No translation available. |
RefSeqi | NP_001295561.1, NM_001308632.1 |
Genome annotation databases
Ensembli | ENST00000595904; ENSP00000472445; ENSG00000062822 |
GeneIDi | 5424 |
UCSCi | uc010eny.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008655 Genomic DNA No translation available. AC020909 Genomic DNA No translation available. |
RefSeqi | NP_001295561.1, NM_001308632.1 |
3D structure databases
SMRi | M0R2B7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | M0R2B7, 1 interactor |
Proteomic databases
EPDi | M0R2B7 |
MaxQBi | M0R2B7 |
PeptideAtlasi | M0R2B7 |
PRIDEi | M0R2B7 |
Protocols and materials databases
Antibodypediai | 3821, 336 antibodies |
Genome annotation databases
Ensembli | ENST00000595904; ENSP00000472445; ENSG00000062822 |
GeneIDi | 5424 |
UCSCi | uc010eny.5, human |
Organism-specific databases
CTDi | 5424 |
EuPathDBi | HostDB:ENSG00000062822.12 |
HGNCi | HGNC:9175, POLD1 |
OpenTargetsi | ENSG00000062822 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00560000077365 |
OMAi | GQQVKFI |
OrthoDBi | 20210at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5424, 739 hits in 851 CRISPR screens |
ChiTaRSi | POLD1, human |
GenomeRNAii | 5424 |
Gene expression databases
Bgeei | ENSG00000062822, Expressed in stomach and 192 other tissues |
ExpressionAtlasi | M0R2B7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_C IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf IPR025687, Znf-C4pol |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 2 hits PF03104, DNA_pol_B_exo1, 1 hit PF14260, zf-C4pol, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M0R2B7_HUMAN | |
Accessioni | M0R2B7Primary (citable) accession number: M0R2B7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |