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UniProtKB - M0R1X7 (M0R1X7_HUMAN)
Protein
Submitted name:
Mucolipin-1
Gene
MCOLN1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Mucolipin-1Imported |
Gene namesi | Name:MCOLN1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13356, MCOLN1 |
VEuPathDBi | HostDB:ENSG00000090674 |
Subcellular locationi
Lysosome
- Lysosome membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endosome
- Endosome membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Late endosome membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endosome
- late endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 31 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 51 – 73 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
MaxQBi | M0R1X7 |
PRIDEi | M0R1X7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090674, Expressed in right adrenal gland and 210 other tissues |
ExpressionAtlasi | M0R1X7, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 77 | PKD_channelInterPro annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 98 – 129 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 98 – 113 | Basic residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000183036 |
HOGENOMi | CLU_1492372_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR039031, Mucolipin IPR013122, PKD1_2_channel |
PANTHERi | PTHR12127, PTHR12127, 1 hit |
Pfami | View protein in Pfam PF08016, PKD_channel, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
M0R1X7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XEAKNLASYD VCSILLGTST LLVWVGVIRY LTFFHNYNIL IATLRVALPS
60 70 80 90 100
VMRFCCCVAV IYLGYCFCGW IVLGPYHVKP LHLHGAQPLH RAHHRRLRHH
110 120 130 140 150
QASRRRRRRG ERAAGLHRTV PGQPHLRQVP PRERLGLQPS LLLRKGPLGG
160 170 180
AFAAGELIRP DCRWTVGPGL QRPPPPTPLI YL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9GZU1 | MCLN1_HUMAN | Mucolipin-1 | MCOLN1 ML4, TRPML1, MSTP080 | 580 | Annotation score: | ||
M0QXD0 | M0QXD0_HUMAN | Mucolipin-1 | MCOLN1 | 200 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008878 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000599334; ENSP00000472176; ENSG00000090674 |
UCSCi | uc060snz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008878 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | M0R1X7 |
PRIDEi | M0R1X7 |
Protocols and materials databases
Antibodypediai | 12053, 165 antibodies from 21 providers |
Genome annotation databases
Ensembli | ENST00000599334; ENSP00000472176; ENSG00000090674 |
UCSCi | uc060snz.1, human |
Organism-specific databases
HGNCi | HGNC:13356, MCOLN1 |
OpenTargetsi | ENSG00000090674 |
VEuPathDBi | HostDB:ENSG00000090674 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183036 |
HOGENOMi | CLU_1492372_0_0_1 |
Miscellaneous databases
ChiTaRSi | MCOLN1, human |
Gene expression databases
Bgeei | ENSG00000090674, Expressed in right adrenal gland and 210 other tissues |
ExpressionAtlasi | M0R1X7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR039031, Mucolipin IPR013122, PKD1_2_channel |
PANTHERi | PTHR12127, PTHR12127, 1 hit |
Pfami | View protein in Pfam PF08016, PKD_channel, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M0R1X7_HUMAN | |
Accessioni | M0R1X7Primary (citable) accession number: M0R1X7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |