UniProtKB - M0R1W6 (M0R1W6_HUMAN)
Protein
Submitted name:
Heterogeneous nuclear ribonucleoprotein L
Gene
HNRNPL
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
GO - Biological processi
- mRNA processing Source: InterPro
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Heterogeneous nuclear ribonucleoprotein LImported |
Gene namesi | Name:HNRNPLImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104824.16 |
HGNCi | HGNC:5045, HNRNPL |
Subcellular locationi
Nucleus
- nucleus Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000104824, Expressed in ventricular zone and 248 other tissues |
ExpressionAtlasi | M0R1W6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 108 | RRMInterPro annotationAdd BLAST | 75 | |
Domaini | 125 – 202 | RRMInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 27 | PolyampholyteSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00990000203586 |
HOGENOMi | CLU_054685_1_1_1 |
Family and domain databases
CDDi | cd12780, RRM1_hnRNPL, 1 hit cd12785, RRM2_hnRNPL, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006536, HnRNP-L/PTB IPR035005, hnRNPL_RRM1 IPR035008, hnRNPL_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR021790, PTBP1_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF11835, RRM_8, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
TIGRFAMsi | TIGR01649, hnRNP-L_PTB, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
M0R1W6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XGSMRRRSVP ARPRGRLGER LENYDDPHKT PASPVVHIRG LIDGVVEADL
60 70 80 90 100
VEALQEFGPI SYVVVMPKKR QALVEFEDVL GACNAVNYAA DNQIYIAGHP
110 120 130 140 150
AFVNYSTSQK ISRPGDSDDS RSVNSVLLFT ILNPIYSITT DVLYTICNPC
160 170 180 190 200
GPVQRIVIFR KNGVQAMVEF DSVQSAQRAK ASLNGADIYS GCCTLKIEYA
210 220
KPTRLNVFKN DQDTWDYTNP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP14866 | HNRPL_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPL HNRPL, P/OKcl.14 | 589 | Annotation score: | ||
M0QXS5 | M0QXS5_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPL | 530 | Annotation score: | ||
A0A3B3ITJ4 | A0A3B3ITJ4_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPL | 537 | Annotation score: | ||
M0QYL7 | M0QYL7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPL | 198 | Annotation score: | ||
B4DVF8 | B4DVF8_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPL | 179 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 220 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008982 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000600233; ENSP00000472150; ENSG00000104824 |
UCSCi | uc060ygh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008982 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | M0R1W6 |
PeptideAtlasi | M0R1W6 |
PRIDEi | M0R1W6 |
Protocols and materials databases
Antibodypediai | 4276, 431 antibodies |
Genome annotation databases
Ensembli | ENST00000600233; ENSP00000472150; ENSG00000104824 |
UCSCi | uc060ygh.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104824.16 |
HGNCi | HGNC:5045, HNRNPL |
OpenTargetsi | ENSG00000104824 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00990000203586 |
HOGENOMi | CLU_054685_1_1_1 |
Miscellaneous databases
ChiTaRSi | HNRNPL, human |
Gene expression databases
Bgeei | ENSG00000104824, Expressed in ventricular zone and 248 other tissues |
ExpressionAtlasi | M0R1W6, baseline and differential |
Family and domain databases
CDDi | cd12780, RRM1_hnRNPL, 1 hit cd12785, RRM2_hnRNPL, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006536, HnRNP-L/PTB IPR035005, hnRNPL_RRM1 IPR035008, hnRNPL_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR021790, PTBP1_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF11835, RRM_8, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
TIGRFAMsi | TIGR01649, hnRNP-L_PTB, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M0R1W6_HUMAN | |
Accessioni | M0R1W6Primary (citable) accession number: M0R1W6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | October 7, 2020 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |