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Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-6

Gene

SIRT6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent protein deacetylase sirtuin-6Imported
Submitted name:
Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae), isoform CRA_iImported
Gene namesi
Name:SIRT6Imported
ORF Names:hCG_2004101Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000077463.14
HGNCiHGNC:14934 SIRT6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000077463

PTM / Processingi

Proteomic databases

MaxQBiM0R1N9
PeptideAtlasiM0R1N9
PRIDEiM0R1N9

Expressioni

Gene expression databases

BgeeiENSG00000077463
ExpressionAtlasiM0R1N9 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 176Deacetylase sirtuin-typeInterPro annotationAdd BLAST176

Phylogenomic databases

eggNOGiKOG1905 Eukaryota
COG0846 LUCA
GeneTreeiENSGT00530000063706

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR003000 Sirtuin
IPR026590 Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146 SIR2, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305 SIRTUIN, 1 hit

Sequencei

Sequence statusi: Complete.

M0R1N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS
60 70 80 90 100
GFPRDKLAEL HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR
110 120 130 140 150
GLRACRGELR DTILDWEDSL PDRDLALADE ASRSGPAGTC RWLPSAGEAA
160 170
WSSSTCSPPS TTAMLTSASM ATLTRS
Length:176
Mass (Da):19,135
Last modified:April 3, 2013 - v1
Checksum:iD6F6E03CE6780C47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006930 Genomic DNA No translation available.
AC016586 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69259.1
RefSeqiNP_001307993.1, NM_001321064.1
UniGeneiHs.423756

Genome annotation databases

EnsembliENST00000594279; ENSP00000472023; ENSG00000077463
GeneIDi51548
UCSCiuc060rum.1 human

Similar proteinsi

Entry informationi

Entry nameiM0R1N9_HUMAN
AccessioniPrimary (citable) accession number: M0R1N9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: July 18, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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