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Protein

Tubulin beta chain

Gene

TUBB4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBB4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104833.10
HGNCiHGNC:20774 TUBB4A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104833

PTM / Processingi

Proteomic databases

EPDiM0R1I1
MaxQBiM0R1I1
PeptideAtlasiM0R1I1
PRIDEiM0R1I1

Expressioni

Gene expression databases

BgeeiENSG00000104833
ExpressionAtlasiM0R1I1 baseline and differential

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliM0R1I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 74TubulinInterPro annotationAdd BLAST72

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061

Family and domain databases

Gene3Di3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002453 Beta_tubulin
IPR000217 Tubulin
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SUPFAMiSSF52490 SSF52490, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Fragment.

M0R1I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVRSGPFG QIFRPDNFVF GQSGAGNNWA KGHYTEGAEL VDAVLDVVRK
60 70
EAESCDCLQG FQLTHSLGGG TGSG
Length:74
Mass (Da):7,778
Last modified:April 3, 2013 - v1
Checksum:i0F1BCAF8A8B59FB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei74Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010503 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000596291; ENSP00000471880; ENSG00000104833
UCSCiuc060sjt.1 human

Similar proteinsi

Entry informationi

Entry nameiM0R1I1_HUMAN
AccessioniPrimary (citable) accession number: M0R1I1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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