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Protein
Submitted name:

Delta-like protein 3

Gene

DLL3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Delta-like protein 3Imported
Gene namesi
Name:DLL3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000090932.10
HGNCiHGNC:2909 DLL3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000090932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500400533527 – 220Sequence analysisAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi151 ↔ 160PROSITE-ProRule annotation
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiM0R177

Expressioni

Gene expression databases

BgeeiENSG00000090932 Expressed in 41 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasiM0R177 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0R177
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 161EGF-likeInterPro annotationAdd BLAST37
Domaini163 – 199EGF-likeInterPro annotationAdd BLAST37
Domaini201 – 220EGF-likeInterPro annotationAdd BLAST20

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00930000150895

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011651 Notch_ligand_N
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07657 MNNL, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M0R177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC
60 70 80 90 100
SARLPCRLFF RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD
110 120 130 140 150
LPLPDGLLQV PFRDAWPGTF SFIIETWREE LGDQIGGGLC LDLGHALRCR
160 170 180 190 200
CRAGFAGPRC EHDLDDCAGR ACANGGTCVE GGGAHRCSCA LGFGGRDCRE
210 220
RADPCAARPC AHGGRCYAHF
Length:220
Mass (Da):23,117
Last modified:April 3, 2013 - v1
Checksum:i6D151E6C33B005A1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NYJ7DLL3_HUMAN
Delta-like protein 3
DLL3
618Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei220Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011500 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000596614; ENSP00000471688; ENSG00000090932
UCSCiuc060ymq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011500 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliM0R177
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiM0R177

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000596614; ENSP00000471688; ENSG00000090932
UCSCiuc060ymq.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000090932.10
HGNCiHGNC:2909 DLL3
OpenTargetsiENSG00000090932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00930000150895

Miscellaneous databases

ChiTaRSiDLL3 human

Gene expression databases

BgeeiENSG00000090932 Expressed in 41 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasiM0R177 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011651 Notch_ligand_N
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07657 MNNL, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiM0R177_HUMAN
AccessioniPrimary (citable) accession number: M0R177
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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