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Protein
Submitted name:

Tyrosine-protein kinase receptor UFO

Gene

AXL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase receptor UFOImported
Gene namesi
Name:AXLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167601.11
HGNCiHGNC:905 AXL

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei182 – 204HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167601

PTM / Processingi

Proteomic databases

PeptideAtlasiM0R0W6
PRIDEiM0R0W6

Expressioni

Gene expression databases

BgeeiENSG00000167601 Expressed in 228 organ(s), highest expression level in synovial joint
ExpressionAtlasiM0R0W6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0R0W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63Fibronectin type-IIIInterPro annotationAdd BLAST63
Domaini68 – 160Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini268 – 539Protein kinaseInterPro annotationAdd BLAST272

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IG6I Eukaryota
COG0515 LUCA
GeneTreeiENSGT00810000125384

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

M0R0W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIQAGEPDP PEEPLTSQAS VPPHQLRLGS LHPHTPYHIR VACTSSQGPS
60 70 80 90 100
SWTHWLPVET PEGVPLGPPE NISATRNGSQ AFVHWQEPRA PLQGTLLGYR
110 120 130 140 150
LAYQGQDTPE VLMDIGLRQE VTLELQGDGS VSNLTVCVAA YTAAGDGPWS
160 170 180 190 200
LPVPLEAWRP GQAQPVHQLV KEPSTPAFSW PWWYVLLGAV VAAACVLILA
210 220 230 240 250
LFLVHRRKKE TRYGEVFEPT VERGELVVRY RVRKSYSRRT TEATLNSLGI
260 270 280 290 300
SEELKEKLRD VMVDRHKVAL GKTLGEGEFG AVMEGQLNQD DSILKVAVKT
310 320 330 340 350
MKIAICTRSE LEDFLSEAVC MKEFDHPNVM RLIGVCFQGS ERESFPAPVV
360 370 380 390 400
ILPFMKHGDL HSFLLYSRLG DQPVYLPTQM LVKFMADIAS GMEYLSTKRF
410 420 430 440 450
IHRDLAARNC MLNENMSVCV ADFGLSKKIY NGDYYRQGRI AKMPVKWIAI
460 470 480 490 500
ESLADRVYTS KSDVWSFGVT MWEIATRGQT PYPGVENSEI YDYLRQGNRL
510 520 530 540 550
KQPADCLDGL YALMSRCWEL NPQDRPSFTE LREDLENTLK ALPPAQEPDE
560 570 580 590 600
ILYVNMDEGG GYPEPPGAAG GADPPTQPDP KDSCSCLTAA EVHPAGRYVL
610 620
CPSTTPSPAQ PADRGSPAAP GQEDGA
Length:626
Mass (Da):69,231
Last modified:April 3, 2013 - v1
Checksum:i66372173936B138F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P30530UFO_HUMAN
Tyrosine-protein kinase receptor UF...
AXL UFO
894Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011510 Genomic DNA No translation available.
KF456581 Genomic DNA No translation available.
KF456582 Genomic DNA No translation available.
RefSeqiNP_001265528.1, NM_001278599.1
UniGeneiHs.590970

Genome annotation databases

EnsembliENST00000593513; ENSP00000471497; ENSG00000167601
GeneIDi558
UCSCiuc032hxy.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011510 Genomic DNA No translation available.
KF456581 Genomic DNA No translation available.
KF456582 Genomic DNA No translation available.
RefSeqiNP_001265528.1, NM_001278599.1
UniGeneiHs.590970

3D structure databases

ProteinModelPortaliM0R0W6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiM0R0W6
PRIDEiM0R0W6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593513; ENSP00000471497; ENSG00000167601
GeneIDi558
UCSCiuc032hxy.2 human

Organism-specific databases

CTDi558
EuPathDBiHostDB:ENSG00000167601.11
HGNCiHGNC:905 AXL
OpenTargetsiENSG00000167601
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6I Eukaryota
COG0515 LUCA
GeneTreeiENSGT00810000125384

Miscellaneous databases

ChiTaRSiAXL human
GenomeRNAii558

Gene expression databases

BgeeiENSG00000167601 Expressed in 228 organ(s), highest expression level in synovial joint
ExpressionAtlasiM0R0W6 baseline and differential

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0R0W6_HUMAN
AccessioniPrimary (citable) accession number: M0R0W6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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