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Protein
Submitted name:

SUMO-activating enzyme subunit 1

Gene

SAE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
SUMO-activating enzyme subunit 1Imported
Gene namesi
Name:SAE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142230.11
HGNCiHGNC:30660 SAE1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142230

PTM / Processingi

Proteomic databases

EPDiM0R054
MaxQBiM0R054
PeptideAtlasiM0R054
PRIDEiM0R054

Expressioni

Gene expression databases

BgeeiENSG00000142230 Expressed in 225 organ(s), highest expression level in muscle layer of sigmoid colon
ExpressionAtlasiM0R054 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0R054
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 148ThiFInterPro annotationAdd BLAST147

Phylogenomic databases

eggNOGiKOG2014 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000075007

Family and domain databases

InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR035985 Ubiquitin-activating_enz
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
SUPFAMiSSF69572 SSF69572, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

M0R054-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDHEQVTPE DPGAQFLIRT GSVGRNRAEA SLERAQNLNP MVDVKVDTED
60 70 80 90 100
IEKKPESFFT QFDAVCLTCC SRDVIVKVDQ ICHKNSIKFF TGDVFGYHGY
110 120 130 140 150
TFANLGEHEF VEEKTKVAKV SQGVEDGPDT KRAKLDSSET TMVKKKVVFC

PVKEALE
Length:157
Mass (Da):17,591
Last modified:April 3, 2013 - v1
Checksum:iF9D0D527D2B76539
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UBE0SAE1_HUMAN
SUMO-activating enzyme subunit 1
SAE1 AOS1, SUA1, UBLE1A
346Annotation score:
B3KNJ4B3KNJ4_HUMAN
SUMO-1 activating enzyme subunit 1,...
SAE1 hCG_20373
299Annotation score:
M0QX65M0QX65_HUMAN
SUMO-activating enzyme subunit 1
SAE1
205Annotation score:
M0QZS6M0QZS6_HUMAN
SUMO-activating enzyme subunit 1
SAE1
265Annotation score:
M0QYM8M0QYM8_HUMAN
SUMO-activating enzyme subunit 1
SAE1
133Annotation score:
M0R286M0R286_HUMAN
SUMO-activating enzyme subunit 1
SAE1
98Annotation score:
M0QYP2M0QYP2_HUMAN
SUMO-activating enzyme subunit 1
SAE1
71Annotation score:
M0R375M0R375_HUMAN
SUMO-activating enzyme subunit 1
SAE1
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei157Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008532 Genomic DNA No translation available.
AC008755 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000594144; ENSP00000471010; ENSG00000142230
UCSCiuc061akl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008532 Genomic DNA No translation available.
AC008755 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliM0R054
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiM0R054
MaxQBiM0R054
PeptideAtlasiM0R054
PRIDEiM0R054

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000594144; ENSP00000471010; ENSG00000142230
UCSCiuc061akl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000142230.11
HGNCiHGNC:30660 SAE1
OpenTargetsiENSG00000142230
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2014 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000075007

Miscellaneous databases

ChiTaRSiSAE1 human

Gene expression databases

BgeeiENSG00000142230 Expressed in 225 organ(s), highest expression level in muscle layer of sigmoid colon
ExpressionAtlasiM0R054 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR035985 Ubiquitin-activating_enz
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
SUPFAMiSSF69572 SSF69572, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0R054_HUMAN
AccessioniPrimary (citable) accession number: M0R054
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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