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Protein

Tubulin beta chain

Gene

TUBB4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBB4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104833.10
HGNCiHGNC:20774 TUBB4A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104833

PTM / Processingi

Proteomic databases

MaxQBiM0R042
PeptideAtlasiM0R042
PRIDEiM0R042

Expressioni

Gene expression databases

BgeeiENSG00000104833 Expressed in 135 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiM0R042 baseline and differential

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliM0R042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 144TubulinInterPro annotationAdd BLAST142

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061

Family and domain databases

Gene3Di3.40.50.1440, 2 hits
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR000217 Tubulin
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.iShow all

M0R042-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREIVHLQAG QCGNQIGAKF WEGAELVDAV LDVVRKEAES CDCLQGFQLT
60 70 80 90 100
HSLGGGTGSG MGTLLISKIR EEFPDRIMNT FSVVPSPKVS DTVVEPYNAT
110 120 130 140
LSVHQLVENT DETYCIDNEA LYDICFRTLK LTTPTYGDLN HLVS
Length:144
Mass (Da):15,825
Last modified:April 3, 2013 - v1
Checksum:i2AF7D5C3ACF18C87
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P04350TBB4A_HUMAN
Tubulin beta-4A chain
TUBB4A TUBB4, TUBB5
444Annotation score:
M0R1I1M0R1I1_HUMAN
Tubulin beta chain
TUBB4A
74Annotation score:
M0R2D3M0R2D3_HUMAN
Tubulin beta-4A chain
TUBB4A
155Annotation score:
M0QYM7M0QYM7_HUMAN
Tubulin beta-4A chain
TUBB4A
160Annotation score:
M0R0X0M0R0X0_HUMAN
Tubulin beta-4A chain
TUBB4A
103Annotation score:
M0QY37M0QY37_HUMAN
Tubulin beta-4A chain
TUBB4A
109Annotation score:
M0QY85M0QY85_HUMAN
Tubulin beta-4A chain
TUBB4A
107Annotation score:
M0QX14M0QX14_HUMAN
Tubulin beta-4A chain
TUBB4A
110Annotation score:
M0R278M0R278_HUMAN
Tubulin beta-4A chain
TUBB4A
167Annotation score:
M0QZL7M0QZL7_HUMAN
Tubulin beta-4A chain
TUBB4A
157Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei144Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010503 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000600216; ENSP00000470983; ENSG00000104833
UCSCiuc060sjp.1 human

Similar proteinsi

Entry informationi

Entry nameiM0R042_HUMAN
AccessioniPrimary (citable) accession number: M0R042
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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