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Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-6

Gene

SIRT6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent protein deacetylase sirtuin-6Imported
Gene namesi
Name:SIRT6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000077463.14
HGNCiHGNC:14934 SIRT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000077463

PTM / Processingi

Proteomic databases

PeptideAtlasiM0QZ09
PRIDEiM0QZ09

Expressioni

Gene expression databases

BgeeiENSG00000077463
ExpressionAtlasiM0QZ09 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0QZ09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 200Deacetylase sirtuin-typeInterPro annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG1905 Eukaryota
COG0846 LUCA
GeneTreeiENSGT00530000063706

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR003000 Sirtuin
IPR026590 Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146 SIR2, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305 SIRTUIN, 1 hit

Sequencei

Sequence statusi: Fragment.

M0QZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DKGKCGLPEI FDPPEELERK VWELARLVWQ SSSVVFHTGA GISTASGIPD
60 70 80 90 100
FRDKLAELHG NMFVEECAKC KTQYVRDTVV GTMGLKATGR LCTVAKARGL
110 120 130 140 150
RACRGELRDT ILDWEDSLPD RDLALADEAS RNADLSITLG TSLQIRPSGN
160 170 180 190 200
LPLATKRRGG RLVIVNLQPT KHDRHADLRI HGYVDEVMTR LMKHLGLEIP
210 220 230 240 250
AWDGPRVLER ALPPLPRPPT PKLEPKEESP TRINGSIPAG PKQEPCAQHN
260 270
GSEPASPKRE RPTSPAPHRP PKRVK
Length:275
Mass (Da):30,383
Last modified:October 5, 2016 - v8
Checksum:i27AAB4B5F2E37F26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei275Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006930 Genomic DNA No translation available.
AC016586 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000597896; ENSP00000470215; ENSG00000077463
UCSCiuc060ruo.1 human

Similar proteinsi

Entry informationi

Entry nameiM0QZ09_HUMAN
AccessioniPrimary (citable) accession number: M0QZ09
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: October 5, 2016
Last modified: July 18, 2018
This is version 49 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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