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Protein
Submitted name:

DNA repair protein XRCC1

Gene

XRCC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair protein XRCC1Imported
Gene namesi
Name:XRCC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000073050.11
HGNCiHGNC:12828 XRCC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000073050

PTM / Processingi

Proteomic databases

EPDiM0QYS5
MaxQBiM0QYS5
PeptideAtlasiM0QYS5
PRIDEiM0QYS5

Expressioni

Gene expression databases

BgeeiENSG00000073050 Expressed in 221 organ(s), highest expression level in right ovary
ExpressionAtlasiM0QYS5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0QYS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 156XRCC1_NInterPro annotationAdd BLAST133

Phylogenomic databases

eggNOGiKOG3226 Eukaryota
ENOG410ZE1H LUCA
GeneTreeiENSGT00390000004140

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR002706 Xrcc1_N
PfamiView protein in Pfam
PF01834 XRCC1_N, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

M0QYS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTPQTSQRG SLAAPLGYFQ VLFKTHCAEN LLKADTYRKW RAAKAGEKTI
60 70 80 90 100
SVVLQLEKEE QIHSVDIGND GSAFVEVLVG SSAGGAGEQD YEVLLVTSSF
110 120 130 140 150
MSPSESRSGS NPNRVRMFGP DKLVRAAAEK RWDRVKIVCS QPYSKDSPFG
160 170 180 190 200
LSFVRFHSPP DKDEAEAPSQ KVTVTKLGQF RVKEEDESAN SLRPGALFFS
210 220 230 240 250
RINKTSPVTA SDPAGPSYAA ATLQASSAAS SASPVSRAIG STSKPQESPK
260 270 280 290
GKRKLDLNQE EKKTPSKPPA QLSPSVPKRP KLPAPTRTPA TA
Length:292
Mass (Da):31,386
Last modified:April 3, 2013 - v1
Checksum:i90C46F228642C4FD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P18887XRCC1_HUMAN
DNA repair protein XRCC1
XRCC1
633Annotation score:
F5H8D7F5H8D7_HUMAN
DNA repair protein XRCC1
XRCC1
602Annotation score:
M0R1U8M0R1U8_HUMAN
DNA repair protein XRCC1
XRCC1
210Annotation score:
M0QZ96M0QZ96_HUMAN
DNA repair protein XRCC1
XRCC1
165Annotation score:
M0R0D2M0R0D2_HUMAN
DNA repair protein XRCC1
XRCC1
172Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei292Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006276 Genomic DNA No translation available.
AC018758 Genomic DNA No translation available.
KC877750 Genomic DNA No translation available.
L34079 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000598165; ENSP00000470045; ENSG00000073050
UCSCiuc060zlx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006276 Genomic DNA No translation available.
AC018758 Genomic DNA No translation available.
KC877750 Genomic DNA No translation available.
L34079 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliM0QYS5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiM0QYS5
MaxQBiM0QYS5
PeptideAtlasiM0QYS5
PRIDEiM0QYS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000598165; ENSP00000470045; ENSG00000073050
UCSCiuc060zlx.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000073050.11
HGNCiHGNC:12828 XRCC1
OpenTargetsiENSG00000073050
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3226 Eukaryota
ENOG410ZE1H LUCA
GeneTreeiENSGT00390000004140

Miscellaneous databases

ChiTaRSiXRCC1 human

Gene expression databases

BgeeiENSG00000073050 Expressed in 221 organ(s), highest expression level in right ovary
ExpressionAtlasiM0QYS5 baseline and differential

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR002706 Xrcc1_N
PfamiView protein in Pfam
PF01834 XRCC1_N, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0QYS5_HUMAN
AccessioniPrimary (citable) accession number: M0QYS5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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