UniProtKB - M0QYI6 (M0QYI6_HUMAN)
Protein
Submitted name:
NEDD8-conjugating enzyme Ubc12
Gene
UBE2M
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 52 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- transferase activity Source: UniProtKB-KW
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: NEDD8-conjugating enzyme Ubc12Imported |
Gene namesi | Name:UBE2MImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130725.7 |
HGNCi | HGNC:12491, UBE2M |
Expressioni
Gene expression databases
Bgeei | ENSG00000130725, Expressed in superior frontal gyrus and 221 other tissues |
ExpressionAtlasi | M0QYI6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 77 | UBC coreInterPro annotationAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000162814 |
HOGENOMi | CLU_2126665_0_0_1 |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
M0QYI6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
FKLVICPDEG FYKSGKFVFS FKVGQGYPHD PPKVKCETMV YHPNIDLEGN
60 70 80 90 100
VCLNILREDW KPVLTINSII YGLQYLFLVS RNRWLGLGRL AFCPSGLLTP
110
PTCTGHRSPT PRTH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP61081 | UBC12_HUMAN | NEDD8-conjugating enzyme Ubc12 | UBE2M UBC12 | 183 | Annotation score: | ||
M0QX69 | M0QX69_HUMAN | NEDD8-conjugating enzyme Ubc12 | UBE2M | 69 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016630 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000596985; ENSP00000469855; ENSG00000130725 |
UCSCi | uc061dup.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016630 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | M0QYI6 |
PeptideAtlasi | M0QYI6 |
PRIDEi | M0QYI6 |
Protocols and materials databases
Antibodypediai | 3333, 191 antibodies |
Genome annotation databases
Ensembli | ENST00000596985; ENSP00000469855; ENSG00000130725 |
UCSCi | uc061dup.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130725.7 |
HGNCi | HGNC:12491, UBE2M |
OpenTargetsi | ENSG00000130725 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162814 |
HOGENOMi | CLU_2126665_0_0_1 |
Miscellaneous databases
ChiTaRSi | UBE2M, human |
Gene expression databases
Bgeei | ENSG00000130725, Expressed in superior frontal gyrus and 221 other tissues |
ExpressionAtlasi | M0QYI6, baseline and differential |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M0QYI6_HUMAN | |
Accessioni | M0QYI6Primary (citable) accession number: M0QYI6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | October 7, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |