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Protein
Submitted name:

NEDD8-conjugating enzyme Ubc12

Gene

UBE2M

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathwayUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
NEDD8-conjugating enzyme Ubc12Imported
Gene namesi
Name:UBE2MImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130725.7
HGNCiHGNC:12491 UBE2M

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130725

PTM / Processingi

Proteomic databases

MaxQBiM0QYI6
PeptideAtlasiM0QYI6
PRIDEiM0QYI6

Expressioni

Gene expression databases

BgeeiENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe
ExpressionAtlasiM0QYI6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0QYI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 77UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0420 Eukaryota
ENOG410XS81 LUCA
GeneTreeiENSGT00630000089859

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M0QYI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FKLVICPDEG FYKSGKFVFS FKVGQGYPHD PPKVKCETMV YHPNIDLEGN
60 70 80 90 100
VCLNILREDW KPVLTINSII YGLQYLFLVS RNRWLGLGRL AFCPSGLLTP
110
PTCTGHRSPT PRTH
Length:114
Mass (Da):12,953
Last modified:April 3, 2013 - v1
Checksum:i7FF52841D4F41AF5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P61081UBC12_HUMAN
NEDD8-conjugating enzyme Ubc12
UBE2M UBC12
183Annotation score:
M0QX69M0QX69_HUMAN
NEDD8-conjugating enzyme Ubc12
UBE2M
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016630 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000596985; ENSP00000469855; ENSG00000130725
UCSCiuc061dup.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016630 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliM0QYI6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiM0QYI6
PeptideAtlasiM0QYI6
PRIDEiM0QYI6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000596985; ENSP00000469855; ENSG00000130725
UCSCiuc061dup.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000130725.7
HGNCiHGNC:12491 UBE2M
OpenTargetsiENSG00000130725
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0420 Eukaryota
ENOG410XS81 LUCA
GeneTreeiENSGT00630000089859

Miscellaneous databases

ChiTaRSiUBE2M human

Gene expression databases

BgeeiENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe
ExpressionAtlasiM0QYI6 baseline and differential

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0QYI6_HUMAN
AccessioniPrimary (citable) accession number: M0QYI6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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