UniProtKB - M0QYI6 (M0QYI6_HUMAN)

BLAST

>tr|M0QYI6|M0QYI6_HUMAN NEDD8-conjugating enzyme Ubc12 (Fragment) OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1
FKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDW
KPVLTINSIIYGLQYLFLVSRNRWLGLGRLAFCPSGLLTPPTCTGHRSPTPRTH

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History
Entry version 42 (12 Sep 2018)
Sequence version 1 (03 Apr 2013)
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Protein

Submitted name:

NEDD8-conjugating enzyme Ubc12

Gene

UBE2M

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	52	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathwayUniRule annotation
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: NEDD8-conjugating enzyme Ubc12Imported
Gene namesⁱ	Name:UBE2MImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130725.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12491 UBE2M

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000130725

OpenTargetsⁱ

ENSG00000130725

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	M0QYI6
PeptideAtlas More...PeptideAtlasⁱ	M0QYI6
PRIDEⁱ	M0QYI6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe
ExpressionAtlasⁱ	M0QYI6 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	M0QYI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 77	UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0420 Eukaryota ENOG410XS81 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089859

Family and domain databases

Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

M0QYI6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
FKLVICPDEG FYKSGKFVFS FKVGQGYPHD PPKVKCETMV YHPNIDLEGN 
        60         70         80         90        100
VCLNILREDW KPVLTINSII YGLQYLFLVS RNRWLGLGRL AFCPSGLLTP 
       110 
PTCTGHRSPT PRTH

Length:114

Mass (Da):12,953

Last modified:April 3, 2013 - v1

Checksum:ⁱ7FF52841D4F41AF5

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

P61081	UBC12_HUMAN	NEDD8-conjugating enzyme Ubc12 NEDD8-conjugating enzyme Ubc12, EC 2.3.2.- (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)	UBE2M UBC12	183	Annotation score:
M0QX69	M0QX69_HUMAN	NEDD8-conjugating enzyme Ubc12 NEDD8-conjugating enzyme Ubc12	UBE2M	69	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC016630 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC016630 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000596985; ENSP00000469855; ENSG00000130725
UCSC genome browser More...UCSCⁱ	uc061dup.1 human

Protein	Similar proteins		Species	Score	Length	Source
M0QYI6	UBE2M isoform 3 (Fragment)		PANTR		114	UniRef100_M0QYI6

Protein	Similar proteins		Species	Score	Length	Source
M0QYI6	Uncharacterized protein		MACMU		104	UniRef90_A0A1D5Q952
UBE2M isoform 3 (Fragment)		PANTR		114

Protein	Similar proteins		Species	Score	Length	Source
M0QYI6	Uncharacterized protein		MACMU		104	UniRef50_A0A1D5Q952
UBE2M isoform 3 (Fragment)		PANTR		114
Uncharacterized protein		CALSU		139

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC016630 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC016630 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	M0QYI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	M0QYI6
PeptideAtlasⁱ	M0QYI6
PRIDEⁱ	M0QYI6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000596985; ENSP00000469855; ENSG00000130725
UCSCⁱ	uc061dup.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130725.7
HGNCⁱ	HGNC:12491 UBE2M
OpenTargetsⁱ	ENSG00000130725
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0420 Eukaryota ENOG410XS81 LUCA
GeneTreeⁱ	ENSGT00630000089859

Miscellaneous databases

ChiTaRSⁱ	UBE2M human

ChiTaRSⁱ

UBE2M human

Gene expression databases

Bgeeⁱ	ENSG00000130725 Expressed in 208 organ(s), highest expression level in right frontal lobe
ExpressionAtlasⁱ	M0QYI6 baseline and differential

Family and domain databases

Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M0QYI6_HUMAN
Accessionⁱ	M0QYI6Primary (citable) accession number: M0QYI6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 3, 2013
	Last sequence update:	April 3, 2013
	Last modified:	September 12, 2018
	This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - M0QYI6 (M0QYI6_HUMAN)

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NEDD8-conjugating enzyme Ubc12

UBE2M

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ