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Protein
Submitted name:

Myosin-14

Gene

MYH14

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 205ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin-14Imported
Gene namesi
Name:MYH14Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105357.15
HGNCiHGNC:23212 MYH14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105357

PTM / Processingi

Proteomic databases

PeptideAtlasiM0QY43
PRIDEiM0QY43

Expressioni

Gene expression databases

BgeeiENSG00000105357 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiM0QY43 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliM0QY43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 101Myosin N-terminal SH3-likeInterPro annotationAdd BLAST51
Domaini105 – 808Myosin motorInterPro annotationAdd BLAST704

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni686 – 708Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili875 – 997Sequence analysisAdd BLAST123

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

M0QY43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW
60 70 80 90 100
TARRLVWVPS ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN
110 120 130 140 150
PPKFSKAEDM AELTCLNEAS VLHNLRERYY SGLIYTYSGL FCVVINPYKQ
160 170 180 190 200
LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG AYRSMLQDRE DQSILCTGES
210 220 230 240 250
GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PASVSTVSYG ELERQLLQAN
260 270 280 290 300
PILEAFGNAK TVKNDNSSRF GKFIRINFDV AGYIVGANIE TYLLEKSRAI
310 320 330 340 350
RQAKDECSFH IFYQLLGGAG EQLKADLLLE PCSHYRFLTN GPSSSPGQER
360 370 380 390 400
ELFQETLESL RVLGFSHEEI ISMLRMVSAV LQFGNIALKR ERNTDQATMP
410 420 430 440 450
DNTAAQKLCR LLGLGVTDFS RALLTPRIKV GRDYVQKAQT KEQADFALEA
460 470 480 490 500
LAKATYERLF RWLVLRLNRA LDRSPRQGAS FLGILDIAGF EIFQLNSFEQ
510 520 530 540 550
LCINYTNEKL QQLFNHTMFV LEQEEYQREG IPWTFLDFGL DLQPCIDLIE
560 570 580 590 600
RPANPPGLLA LLDEECWFPK ATDKSFVEKV AQEQGGHPKF QRPRHLRDQA
610 620 630 640 650
DFSVLHYAGK VDYKANEWLM KNMDPLNDNV AALLHQSTDR LTAEIWKDVE
660 670 680 690 700
GIVGLEQVSS LGDGPPGGRP RRGMFRTVGQ LYKESLSRLM ATLSNTNPSF
710 720 730 740 750
VRCIVPNHEK RAGKLEPRLV LDQLRCNGVL EGIRICRQGF PNRILFQEFR
760 770 780 790 800
QRYEILTPNA IPKGFMDGKQ ACEKMIQALE LDPNLYRVGQ SKIFFRAGVL
810 820 830 840 850
AQLEEERDLK VTDIIVSFQA AARGYLARRA FQKRQQQQSA LRVMQRNCAA
860 870 880 890 900
YLKLRHWQWW RLFTKVKPLL QVTRQDEVLQ ARAQELQKVQ ELQQQSAREV
910 920 930 940 950
GELQGRVAQL EEERARLAEQ LRAEAELCAE AEETRGRLAA RKQELELVVS
960 970 980 990 1000
ELEARVGEEE ECSRQMQTEK KRLQQHIQEL EAHLEAEEGA RQKLQLEKVT

TE
Length:1,002
Mass (Da):113,783
Last modified:October 5, 2016 - v8
Checksum:i8B823205F31743D8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z406MYH14_HUMAN
Myosin-14
MYH14 KIAA2034, FP17425
1,995Annotation score:
A0A2R8Y4C3A0A2R8Y4C3_HUMAN
Myosin-14
MYH14
371Annotation score:
A0A2R8Y454A0A2R8Y454_HUMAN
Myosin-14
MYH14
135Annotation score:
A1L2Z2A1L2Z2_HUMAN
MYH14 protein
MYH14
638Annotation score:
A0A0C4DFM8A0A0C4DFM8_HUMAN
Myosin-14
MYH14
508Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1002Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008655 Genomic DNA No translation available.
AC010515 Genomic DNA No translation available.
AC020906 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000599920; ENSP00000469573; ENSG00000105357
UCSCiuc061bpd.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008655 Genomic DNA No translation available.
AC010515 Genomic DNA No translation available.
AC020906 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliM0QY43
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiM0QY43
PRIDEiM0QY43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000599920; ENSP00000469573; ENSG00000105357
UCSCiuc061bpd.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105357.15
HGNCiHGNC:23212 MYH14
OpenTargetsiENSG00000105357
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919

Miscellaneous databases

ChiTaRSiMYH14 human

Gene expression databases

BgeeiENSG00000105357 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiM0QY43 baseline and differential

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0QY43_HUMAN
AccessioniPrimary (citable) accession number: M0QY43
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 52 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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