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UniProtKB - M0QXL5 (M0QXL5_HUMAN)
Protein
Submitted name:
rRNA 2'-O-methyltransferase fibrillarin
Gene
FBL
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- methyltransferase activity Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- methylation Source: UniProtKB-KW
- rRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | MethyltransferaseARBA annotation, RibonucleoproteinARBA annotation, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: rRNA 2'-O-methyltransferase fibrillarinImported |
Gene namesi | Name:FBLImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3599, FBL |
VEuPathDBi | HostDB:ENSG00000105202 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105202, Expressed in testis and 246 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00550000074792 |
HOGENOMi | CLU_059055_1_0_1 |
Family and domain databases
HAMAPi | MF_00351, RNA_methyltransf_FlpA, 1 hit |
InterProi | View protein in InterPro IPR000692, Fibrillarin IPR020813, Fibrillarin_CS IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF01269, Fibrillarin, 1 hit |
PIRSFi | PIRSF006540, Nop17p, 1 hit |
PRINTSi | PR00052, FIBRILLARIN |
SMARTi | View protein in SMART SM01206, Fibrillarin, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS00566, FIBRILLARIN, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
M0QXL5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GRGGFGGGRG RGGGFRGNQS GKNVMVEPHR HEGVFICRGK EDALVTKNLV
60 70 80 90 100
PGESVYGEKR VSISEGDDKI EYRAWNPFRS KLAAAILGGV DQIHIKPGAK
110 120 130 140 150
VLYLGAASGT TVSHVSDIVG PDGLVYAVEF SHRSGRDLIN LAKKRTNIIP
160 170 180 190 200
VIEDARHPHK YRMLIAMVDV IFADVAQPDQ TRIVALNAHT FLRNGGHFVI
210 220 230 240
SIKANCIDST ASAEAVFASE VKKMQQENMK PQEQLTLEPY ERDH
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP22087 | FBRL_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL FIB1, FLRN | 321 | Annotation score: | ||
M0R0P1 | M0R0P1_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 228 | Annotation score: | ||
M0R2Q4 | M0R2Q4_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 273 | Annotation score: | ||
M0R2B0 | M0R2B0_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 182 | Annotation score: | ||
M0R1H0 | M0R1H0_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 178 | Annotation score: | ||
M0R2U2 | M0R2U2_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 157 | Annotation score: | ||
M0R299 | M0R299_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 229 | Annotation score: | ||
M0QXC9 | M0QXC9_HUMAN | rRNA 2'-O-methyltransferase fibrill... | FBL | 40 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 244 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005393 Genomic DNA No translation available. AC006950 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000597224; ENSP00000469249; ENSG00000105202 ENST00000629606; ENSP00000485785; ENSG00000280548 |
UCSCi | uc060ynm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005393 Genomic DNA No translation available. AC006950 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3594, 394 antibodies from 40 providers |
Genome annotation databases
Ensembli | ENST00000597224; ENSP00000469249; ENSG00000105202 ENST00000629606; ENSP00000485785; ENSG00000280548 |
UCSCi | uc060ynm.1, human |
Organism-specific databases
HGNCi | HGNC:3599, FBL |
OpenTargetsi | ENSG00000105202 |
VEuPathDBi | HostDB:ENSG00000105202 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00550000074792 |
HOGENOMi | CLU_059055_1_0_1 |
Miscellaneous databases
ChiTaRSi | FBL, human |
Gene expression databases
Bgeei | ENSG00000105202, Expressed in testis and 246 other tissues |
Family and domain databases
HAMAPi | MF_00351, RNA_methyltransf_FlpA, 1 hit |
InterProi | View protein in InterPro IPR000692, Fibrillarin IPR020813, Fibrillarin_CS IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF01269, Fibrillarin, 1 hit |
PIRSFi | PIRSF006540, Nop17p, 1 hit |
PRINTSi | PR00052, FIBRILLARIN |
SMARTi | View protein in SMART SM01206, Fibrillarin, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS00566, FIBRILLARIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M0QXL5_HUMAN | |
Accessioni | M0QXL5Primary (citable) accession number: M0QXL5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |