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Entry version 54 (16 Oct 2019)
Sequence version 1 (03 Apr 2013)
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Protein
Submitted name:

Protein Wiz

Gene

WIZ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein WizImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WIZImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30917 WIZ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000011451

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
M0QXA7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
M0QXA7

PeptideAtlas

More...
PeptideAtlasi
M0QXA7

PRoteomics IDEntifications database

More...
PRIDEi
M0QXA7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
M0QXA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000011451 Expressed in 207 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M0QXA7 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 76C2H2-typeInterPro annotationAdd BLAST23
Domaini227 – 249C2H2-typeInterPro annotationAdd BLAST23
Domaini360 – 387C2H2-typeInterPro annotationAdd BLAST28
Domaini544 – 571C2H2-typeInterPro annotationAdd BLAST28
Domaini714 – 736C2H2-typeInterPro annotationAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 221DisorderedSequence analysisAdd BLAST66
Regioni285 – 312DisorderedSequence analysisAdd BLAST28
Regioni408 – 492DisorderedSequence analysisAdd BLAST85
Regioni600 – 648DisorderedSequence analysisAdd BLAST49
Regioni780 – 871DisorderedSequence analysisAdd BLAST92
Regioni946 – 968DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi185 – 203PolarSequence analysisAdd BLAST19
Compositional biasi298 – 312Pro-richSequence analysisAdd BLAST15
Compositional biasi454 – 471Pro-richSequence analysisAdd BLAST18
Compositional biasi620 – 634Pro-richSequence analysisAdd BLAST15
Compositional biasi844 – 860PolyampholyteSequence analysisAdd BLAST17

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159979

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIKKSQR

Database of Orthologous Groups

More...
OrthoDBi
434804at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

M0QXA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAMDLGSPS LPKKSLPVPG ALEQVASRLS SKVAAEVPHG SKQELQDLKA
60 70 80 90 100
QSLTTCEVCG ACFETRKGLS SHARSHLRQL GVAESESSGA PIDLLYELVK
110 120 130 140 150
QKGLPDAHLG LPPGLAKKSS SLKEVVAGAP RPGLLSLAKP LDAPAVNKAI
160 170 180 190 200
KSPPGFSAKG LGHPPSSPLL KKTPLALAGS PTPKNPEDKS PQLSLSPRPA
210 220 230 240 250
SPKAQWPQSE DEGPLNLTLD SDGGRELDCQ LCGAWFETRK GLSSHARAHL
260 270 280 290 300
RHLGVSDPDA KGSPIDVLHG LIRRDGVQIR LPPRRGALAH PGRPPPTSAA
310 320 330 340 350
LSLLPPPPPA KKAKLKAAGM ASPWGKQDLS AAAAAGIFWA SDVEPSPLNL
360 370 380 390 400
SSGPEPARDI RCEFCGEFFE NRKGLSSHAR SHLRQMGVTE WYVNGSPIDT
410 420 430 440 450
LREILKRRTQ SRPGGPPNPP GPSPKALAKM MGGAGPGSSL EARSPSDLHI
460 470 480 490 500
SPLAKKLPPP PGSPLGHSPT ASPPPTARKM FPGLAAPSLP KKLKPEQIRV
510 520 530 540 550
EIKREMLPGA LHGELHPSEG PWGAPREDMT PLNLSSRAEP VRDIRCEFCG
560 570 580 590 600
EFFENRKGLS SHARSHLRQM GVTEWSVNGS PIDTLREILK KKSKPCLIKK
610 620 630 640 650
EPPAGDLAPA LAEDGPPTVA PGPVQSPLPL SPLAGRPGKP GAGPAQVPRE
660 670 680 690 700
LSLTPITGAK PSATGYLGSV AAKRPLQEDR LLPAEVKAKT YIQTELPFKA
710 720 730 740 750
KTLHEKTSHS STEACCELCG LYFENRKALA SHARAHLRQF GVTEWCVNGS
760 770 780 790 800
PIETLSEWIK HRPQKVGAYR SYIQGGRPFT KKFRSAGHGR DSDKRPSLGL
810 820 830 840 850
APGGLAVVGR SAGGEPGPEA GRAADGGERP LAASPPGTVK AEEHQRQNIN
860 870 880 890 900
KFERRQARPP DASAARGGED TNDLQQKLEE VRQPPPRVRP VPSLVPRPPQ
910 920 930 940 950
TSLVKFVGNI YTLKCRFCEV EFQGPLSIQE EWVRHLQRHI LEMNFSKADP
960
PPEESQAPQA QTAAAEAP
Length:968
Mass (Da):103,279
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF8BB4E5A5BE125C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95785WIZ_HUMAN
Protein Wiz
WIZ ZNF803
1,651Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9EGQ5B9EGQ5_HUMAN
Protein Wiz
WIZ
832Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFV2A0A2R8YFV2_HUMAN
Protein Wiz
WIZ
1,699Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXF8M0QXF8_HUMAN
Protein Wiz
WIZ
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS05A0A3B3IS05_HUMAN
Protein Wiz
WIZ
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006128 Genomic DNA No translation available.
AC007059 Genomic DNA No translation available.
AC011492 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005260066.1, XM_005260009.2
XP_005260067.1, XM_005260010.3
XP_011526465.1, XM_011528163.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000599910; ENSP00000469022; ENSG00000011451

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58525

UCSC genome browser

More...
UCSCi
uc060utv.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006128 Genomic DNA No translation available.
AC007059 Genomic DNA No translation available.
AC011492 Genomic DNA No translation available.
RefSeqiXP_005260066.1, XM_005260009.2
XP_005260067.1, XM_005260010.3
XP_011526465.1, XM_011528163.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiM0QXA7

Proteomic databases

jPOSTiM0QXA7
MaxQBiM0QXA7
PeptideAtlasiM0QXA7
PRIDEiM0QXA7

Genome annotation databases

EnsembliENST00000599910; ENSP00000469022; ENSG00000011451
GeneIDi58525
UCSCiuc060utv.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
58525
HGNCiHGNC:30917 WIZ
OpenTargetsiENSG00000011451

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000159979
OMAiYIKKSQR
OrthoDBi434804at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WIZ human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
58525

Gene expression databases

BgeeiENSG00000011451 Expressed in 207 organ(s), highest expression level in right testis
ExpressionAtlasiM0QXA7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM0QXA7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M0QXA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: October 16, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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