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Protein
Submitted name:

Glutamate-rich WD repeat-containing protein 1

Gene

GRWD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate-rich WD repeat-containing protein 1Imported
Gene namesi
Name:GRWD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105447.12
HGNCiHGNC:21270 GRWD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105447

PTM / Processingi

Proteomic databases

MaxQBiM0QX71
PeptideAtlasiM0QX71
PRIDEiM0QX71

Expressioni

Gene expression databases

BgeeiENSG00000105447 Expressed in 224 organ(s), highest expression level in prostate gland
ExpressionAtlasiM0QX71 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM0QX71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 228WD_REPEATS_REGIONInterPro annotationAdd BLAST122
Repeati154 – 189WDPROSITE-ProRule annotationAdd BLAST36
Repeati201 – 228WDPROSITE-ProRule annotationAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 41Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0302 Eukaryota
ENOG410XPDB LUCA
GeneTreeiENSGT00550000075124

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M0QX71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLRMHNLHG TKPPPSEGSD EEEEEEDEED EEERKPQLEL AMVPHYGGIN
60 70 80 90 100
RVRVSWLGEE PVAGVWSEKG QVEVFALRRL LQVVEEPQAL AAFLRDEQAQ
110 120 130 140 150
MKPIFSFAGH MGEGFALDWS PRVTGRLLTG DCQKNIHLWT PTDGGSWHVD
160 170 180 190 200
QRPFVGHTRS VEDLQWSPTE NTVFASCSAD ASIRIWDIRA APSKACMLTT
210 220
ATAHDGDVNV ISWSRREPFL LSGGDDGA
Length:228
Mass (Da):25,477
Last modified:April 3, 2013 - v1
Checksum:i617D8F1EC292A63D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BQ67GRWD1_HUMAN
Glutamate-rich WD repeat-containing...
GRWD1 GRWD, KIAA1942, WDR28
446Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei228Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008403 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000598711; ENSP00000468943; ENSG00000105447
UCSCiuc061ati.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008403 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliM0QX71
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiM0QX71
PeptideAtlasiM0QX71
PRIDEiM0QX71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000598711; ENSP00000468943; ENSG00000105447
UCSCiuc061ati.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105447.12
HGNCiHGNC:21270 GRWD1
OpenTargetsiENSG00000105447
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0302 Eukaryota
ENOG410XPDB LUCA
GeneTreeiENSGT00550000075124

Gene expression databases

BgeeiENSG00000105447 Expressed in 224 organ(s), highest expression level in prostate gland
ExpressionAtlasiM0QX71 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM0QX71_HUMAN
AccessioniPrimary (citable) accession number: M0QX71
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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