Ascl4

Functionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription by RNA polymerase II Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Achaete-scute family bHLH transcription factor 4Imported
Gene namesⁱ	Name:Ascl4Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1914591 Ascl4

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	M0QW46
PRIDEⁱ	M0QW46

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000085111 Expressed in 16 organ(s), highest expression level in female gonad
ExpressionAtlasⁱ	M0QW46 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000137650

STRINGⁱ

10090.ENSMUSP00000137650

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	M0QW46
SMRⁱ	M0QW46
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	59 – 111	BHLHInterPro annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063321
InParanoidⁱ	M0QW46
KEGG Orthology (KO) More...KOⁱ	K09067
OMAⁱ	AIGYIKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGL

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR015660 MASH1/Ascl1a-like
PANTHERⁱ	PTHR13935 PTHR13935, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

M0QW46-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKRRSAGLL ALPSALRTAP LGALPGREPC RVSVRQDAAD CARRRPYSSL 
        60         70         80         90        100
PLGGVAEPAF LRQRNERERQ RVRCVNEGYA RLRQHLPREL AGQRLSKVET 
       110        120        130        140 
LRAAISYIKQ LQELLERHRP DCNSDGESKA SSGASPCSES EERS

Length:144

Mass (Da):16,063

Last modified:April 3, 2013 - v1

Checksum:ⁱ9ACF372D10DD0F05

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0QWE9	M0QWE9_MOUSE		Achaete-scute family bHLH transcrip... Achaete-scute family bHLH transcription factor 4	Ascl4	50	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC151901 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157086.1, NM_001163614.1
UniGeneⁱ	Mm.382315 Mm.483654

Genome annotation databases

Ensemblⁱ	ENSMUST00000170396; ENSMUSP00000137650; ENSMUSG00000085111
GeneIDⁱ	67341
KEGGⁱ	mmu:67341
UCSC genome browser More...UCSCⁱ	uc011xkr.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
M0QW46	Achaete-scute family bHLH transcription factor 4		HORSE		162	UniRef50_F6ZHM0
achaete-scute homolog 4		MESAU		144
Putative achaete-scute-like protein		CRIGR		144
achaete-scute homolog 4		Enhydra lutris kenyoni		171
Uncharacterized protein		MYOLU		163
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC151901 Genomic DNA No translation available.
RefSeqⁱ	NP_001157086.1, NM_001163614.1
UniGeneⁱ	Mm.382315 Mm.483654

3D structure databases

ProteinModelPortalⁱ	M0QW46
SMRⁱ	M0QW46
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000137650

STRINGⁱ

10090.ENSMUSP00000137650

Proteomic databases

PaxDbⁱ	M0QW46
PRIDEⁱ	M0QW46

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000170396; ENSMUSP00000137650; ENSMUSG00000085111
GeneIDⁱ	67341
KEGGⁱ	mmu:67341
UCSCⁱ	uc011xkr.1 mouse

Organism-specific databases

CTDⁱ	121549
MGIⁱ	MGI:1914591 Ascl4

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00530000063321
InParanoidⁱ	M0QW46
KOⁱ	K09067
OMAⁱ	AIGYIKH
OrthoDBⁱ	EOG091G0OGL

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000085111 Expressed in 16 organ(s), highest expression level in female gonad
ExpressionAtlasⁱ	M0QW46 baseline and differential

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR015660 MASH1/Ascl1a-like
PANTHERⁱ	PTHR13935 PTHR13935, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M0QW46_MOUSE
Accessionⁱ	M0QW46Primary (citable) accession number: M0QW46
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 3, 2013
	Last sequence update:	April 3, 2013
	Last modified:	September 12, 2018
	This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - M0QW46 (M0QW46_MOUSE)

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Achaete-scute family bHLH transcription factor 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ