The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - M0QW46 (M0QW46_MOUSE)
Protein
Submitted name:
Achaete-scute family bHLH transcription factor 4
Gene
Ascl4
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Achaete-scute family bHLH transcription factor 4 |
Gene namesi | Name:Ascl4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914591, Ascl4 |
VEuPathDBi | HostDB:ENSMUSG00000085111 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000085111, Expressed in undifferentiated genital tubercle and 61 other tissues |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000137650 |
Miscellaneous databases
RNActi | M0QW46, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 111 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 144 | DisorderedSequence analysisAdd BLAST | 26 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162902 |
HOGENOMi | CLU_095919_1_0_1 |
InParanoidi | M0QW46 |
OMAi | RLDAACW |
OrthoDBi | 1545499at2759 |
PhylomeDBi | M0QW46 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR015660, MASH1/Ascl1a-like |
PANTHERi | PTHR13935, PTHR13935, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
M0QW46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKRRSAGLL ALPSALRTAP LGALPGREPC RVSVRQDAAD CARRRPYSSL
60 70 80 90 100
PLGGVAEPAF LRQRNERERQ RVRCVNEGYA RLRQHLPREL AGQRLSKVET
110 120 130 140
LRAAISYIKQ LQELLERHRP DCNSDGESKA SSGASPCSES EERS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QWE9 | M0QWE9_MOUSE | Achaete-scute family bHLH transcrip... | Ascl4 | 50 | Annotation score: |
Sequence databases
RefSeqi | NP_001157086.1, NM_001163614.1 |
Genome annotation databases
Ensembli | ENSMUST00000170396.3; ENSMUSP00000137650.2; ENSMUSG00000085111.4 |
GeneIDi | 67341 |
KEGGi | mmu:67341 |
UCSCi | uc011xkr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001157086.1, NM_001163614.1 |
3D structure databases
AlphaFoldDBi | M0QW46 |
SMRi | M0QW46 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000137650 |
Proteomic databases
PaxDbi | M0QW46 |
ProteomicsDBi | 369564 |
Protocols and materials databases
Antibodypediai | 30729, 34 antibodies from 17 providers |
Genome annotation databases
Ensembli | ENSMUST00000170396.3; ENSMUSP00000137650.2; ENSMUSG00000085111.4 |
GeneIDi | 67341 |
KEGGi | mmu:67341 |
UCSCi | uc011xkr.1, mouse |
Organism-specific databases
CTDi | 121549 |
MGIi | MGI:1914591, Ascl4 |
VEuPathDBi | HostDB:ENSMUSG00000085111 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162902 |
HOGENOMi | CLU_095919_1_0_1 |
InParanoidi | M0QW46 |
OMAi | RLDAACW |
OrthoDBi | 1545499at2759 |
PhylomeDBi | M0QW46 |
Miscellaneous databases
BioGRID-ORCSi | 67341, 1 hit in 68 CRISPR screens |
RNActi | M0QW46, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000085111, Expressed in undifferentiated genital tubercle and 61 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR015660, MASH1/Ascl1a-like |
PANTHERi | PTHR13935, PTHR13935, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M0QW46_MOUSE | |
Accessioni | M0QW46Primary (citable) accession number: M0QW46 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | May 25, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |